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The annotation and conditions in this rule are derived from the following entries: P10584 (MDH_THETH), Q8NN33 (MDH_CORGL), Q82HS2 (MDH_STRAW), Q9K3J3 (MDH_STRCO)

If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_01517
    • taxon = Bacteria
    • fragment ≠ the sequence is fragmented

Special conditions

    • Subsequence at position 11 - 17 aligns to "G-[AG]-x-G-x-[IV]-[GACS]" in entry P10584 (individually applies "NAD")
    • Subsequence at position 92 - 92 aligns to "R" in entry P10584 (individually applies "Substrate")
    • Subsequence at position 98 - 98 aligns to "R" in entry P10584 (individually applies "Substrate")
    • Subsequence at position 105 - 105 aligns to "N" in entry P10584 (individually applies "NAD")
    • Subsequence at position 112 - 112 aligns to "Q" in entry P10584 (individually applies "NAD")
    • Subsequence at position 129 - 131 aligns to "[VT]-G-N" in entry P10584 (individually applies "NAD")
    • Subsequence at position 131 - 131 aligns to "N" in entry P10584 (individually applies "Substrate")
    • Subsequence at position 162 - 162 aligns to "R" in entry P10584 (individually applies "Substrate")
    • Subsequence at position 187 - 187 aligns to "H" in entry P10584 (individually applies "Proton acceptor")

... then these annotations are applied i

Protein namei

  • Recommended name:
    Malate dehydrogenase (EC:1.1.1.37)

Gene namei

  • Name:mdh

Catalytic activityi

  • (S)-malate + NAD+ = oxaloacetate + NADH.

Sequence similaritiesi

Functioni

  • Catalyzes the reversible oxidation of malate to oxaloacetate.

Active sitei

  • Proton acceptor (to residues corresponding to position 187)

Binding sitei

  • Substrate (to residues corresponding to position 92)
  • Substrate (to residues corresponding to position 98)
  • NAD (to residues corresponding to position 105)
  • NAD (to residues corresponding to position 112)
  • Substrate (to residues corresponding to position 131)
  • Substrate (to residues corresponding to position 162)

Nucleotide bindingi

  • NAD (to residues corresponding to positions 11 - 17)
  • NAD (to residues corresponding to positions 129 - 131)

Keywordsi

GO (Gene Ontology) termsi

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