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The annotation and conditions in this rule are derived from the following entries: Q46893 (ISPD_ECOLI)

If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_00108
    • taxon = Bacteria
    • fragment ≠ the sequence is fragmented
    • Does not match HAMAP signature MF_01520

Special conditions

    • Subsequence at position 20 - 20 aligns to "R" in entry Q46893 (individually applies "Transition state stabilizer")
    • Subsequence at position 27 - 27 aligns to "K" in entry Q46893 (individually applies "Transition state stabilizer")
    • Subsequence at position 157 - 157 aligns to "R" in entry Q46893 (individually applies "Positions MEP for the nucleophilic attack")
    • Subsequence at position 213 - 213 aligns to "K" in entry Q46893 (individually applies "Positions MEP for the nucleophilic attack")

... then these annotations are applied i

Protein namei

  • Recommended name:
    2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC:2.7.7.60)
    Alternative name(s):
    MEP cytidylyltransferase
    Short name:
    MCT
    4-diphosphocytidyl-2C-methyl-D-erythritol synthase

Gene namei

  • Name:ispD

Functioni

  • Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

Sequence similaritiesi

Catalytic activityi

  • CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol.

Subunit structurei

  • Homodimer.

Pathwayi

Sitei

  • Transition state stabilizer (to residues corresponding to position 20)
  • Transition state stabilizer (to residues corresponding to position 27)
  • Positions MEP for the nucleophilic attack (to residues corresponding to position 157)
  • Positions MEP for the nucleophilic attack (to residues corresponding to position 213)

Keywordsi

GO (Gene Ontology) termsi

  • GO:0016114 terpenoid biosynthetic process
  • GO:0050518 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
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