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The annotation and conditions in this rule are derived from the following entries: P21170 (SPEA_ECOLI)

If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_01417
    • taxon = Bacteria
    • fragment ≠ the sequence is fragmented

Special conditions

    • Subsequence at position 127 - 127 aligns to "K" in entry P21170 (individually applies "N6-(pyridoxal phosphate)lysine")
    • Subsequence at position 307 - 317 aligns to "[FIVLC]-[DN]-[IV]-G-G-G-L-[GA]-[VI]-D-[YF]" in entry P21170 (individually applies "Substrate-binding")

... then these annotations are applied i

Protein namei

  • Recommended name:
    Biosynthetic arginine decarboxylase (EC:
    Short name:

Gene namei

  • Name:speA


  • Pathwayi: agmatine biosynthesis

    This protein is involved in step 1 of the subpathway that synthesizes agmatine from L-arginine. This subpathway is part of the pathway agmatine biosynthesis, which is itself part of Amine and polyamine biosynthesis.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes agmatine from L-arginine, the pathway agmatine biosynthesis and in Amine and polyamine biosynthesis.


Sequence similaritiesi

Catalytic activityi

  • L-arginine = agmatine + CO2.


  • Catalyzes the biosynthesis of agmatine from arginine.


  • Substrate-binding (to residues corresponding to positions 307 - 317)

Modified residuei

  • N6-(pyridoxal phosphate)lysine (to residues corresponding to position 127)


GO (Gene Ontology) termsi

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