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The annotation and conditions in this rule are derived from the following entries: P52061 (IXTPA_ECOLI), Q57679 (IXTPA_METJA), O59580 (IXTPA_PYRHO), O28046 (IXTPA_ARCFU)

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 7 - 12 aligns to "[TS]-x-[NSH]-x-x-K" in entry O59580 (individually applies "Substrate binding")
    • Subsequence at position 36 - 36 aligns to "[ED]" in entry O59580 (individually applies "Magnesium")
    • Subsequence at position 65 - 65 aligns to "D" in entry O59580 (individually applies "Proton acceptor")
    • Subsequence at position 65 - 65 aligns to "D" in entry O59580 (individually applies "Magnesium")
    • Subsequence at position 66 - 66 aligns to "[STA]" in entry O59580 (individually applies "Substrate; via amide nitrogen")
    • Subsequence at position 140 - 143 aligns to "[FWH]-x-x-[DN]" in entry O59580 (individually applies "Substrate binding")
    • Subsequence at position 163 - 163 aligns to "K" in entry O59580 (individually applies "Substrate")
    • Subsequence at position 168 - 169 aligns to "H-R" in entry O59580 (individually applies "Substrate binding")

... then these annotations are applied i

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namei

  • Recommended name:
    dITP/XTP pyrophosphatase (EC:3.6.1.66)
    Alternative name(s):
    Nucleoside-triphosphate diphosphatase
    Nucleoside-triphosphate pyrophosphatase
    Short name:
    NTPase
    Non-canonical purine NTP pyrophosphatase
    Non-standard purine NTP pyrophosphatase

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

  • Homodimer.

<p>This section describes the function(s) of a protein.<p><a href='/help/function' target='_top'>More...</a></p>Functioni

  • Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei

  • Substrate; via amide nitrogen (to residues corresponding to position 66)
  • Substrate (to residues corresponding to position 163)

<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni

  • Substrate binding (to residues corresponding to positions 7 - 12)
  • Substrate binding (to residues corresponding to positions 140 - 143)
  • Substrate binding (to residues corresponding to positions 168 - 169)

<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei

  • Proton acceptor (to residues corresponding to position 65)

<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi

  • Magnesium (to residues corresponding to position 36)
  • Magnesium (to residues corresponding to position 65)

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO (Gene Ontology) termsi

  • GO:0009146 purine nucleoside triphosphate catabolic process
  • GO:0047429 nucleoside-triphosphate diphosphatase activity
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