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The annotation and conditions in this rule are derived from the following entries: P0A9Q5 (ACCD_ECOLI), Q5HF73 (ACCD_STAAC), Q2MI91 (ACCD_SOLLC), P18823 (ACCD_PEA)

If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_01395
    • taxon = Bacteria
    • fragment ≠ the sequence is fragmented
    • Matches HAMAP signature MF_01395
    • gene location = Plastid
    • fragment ≠ the sequence is fragmented

Special conditions

    • taxon ≠ Mycobacterium Subsequence at position 27 - 27 aligns to "C" in entry P0A9Q5 Subsequence at position 30 - 30 aligns to "C" in entry P0A9Q5 Subsequence at position 46 - 46 aligns to "C" in entry P0A9Q5 Subsequence at position 49 - 49 aligns to "C" in entry P0A9Q5
    • gene location = Plastid; Chloroplast
    • gene location ≠ Plastid; Chloroplast
    • gene location = Plastid; Chloroplast
    • taxon ≠ Bacteria
    • taxon ≠ Mycobacterium
    • Subsequence at position 27 - 49 aligns to "C-x(1,2)-C-x(12,18)-C-x(1,2)-C" in entry P0A9Q5
  • taxon ≠ Mycobacterium Subsequence at position 27 - 27 aligns to "C" in entry P0A9Q5 (applies "Zinc") Subsequence at position 30 - 30 aligns to "C" in entry P0A9Q5 (applies "Zinc") Subsequence at position 46 - 46 aligns to "C" in entry P0A9Q5 (applies "Zinc") Subsequence at position 49 - 49 aligns to "C" in entry P0A9Q5 (applies "Zinc")

... then these annotations are applied i

Protein namesi

  • Recommended name:
    Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic (EC:2.1.3.15)
    Short name:
    ACCase subunit beta
    Short name:
    Acetyl-CoA carboxylase carboxyltransferase subunit beta
  • Recommended name:
    Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (EC:2.1.3.15)
    Short name:
    ACCase subunit beta
    Short name:
    Acetyl-CoA carboxylase carboxyltransferase subunit beta

Gene namei

  • Name:accD

Pathwayi

  • Pathwayi: malonyl-CoA biosynthesis

    This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA. This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

Subunit structurei

  • Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein, biotin carboxylase and two subunits each of ACCase subunit alpha and ACCase plastid-coded subunit beta (accD).
  • Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).

Cofactori

  • Zn2+Note: Binds 1 zinc ion per subunit.

Subcellular locationi

Functioni

  • Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.

Catalytic activityi

  • [Biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA = [biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA.

Sequence similaritiesi

Metal bindingi

  • Zinc (to residues corresponding to position 27)
  • Zinc (to residues corresponding to position 30)
  • Zinc (to residues corresponding to position 46)
  • Zinc (to residues corresponding to position 49)

Zinc fingeri

  • C4-type (to residues corresponding to positions 27 - 49)

Keywordsi

GO (Gene Ontology) termsi

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Main funding by: National Institutes of Health

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