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The annotation and conditions in this rule are derived from the following entries: P07813 (SYL_ECOLI)

If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_00049_A
    • taxon = Archaea
    • fragment ≠ the sequence is fragmented

Special conditions

    • taxon = Bacteria
    • Subsequence at position 42 - 52 aligns to "[SP]-[YF]-[PLVT]-[SN]-[GAS]-x(1,3)-H-[LIVMA]-G-[HS]" in entry P07813 (individually applies ""HIGH" region")
    • Subsequence at position 619 - 623 aligns to "[KRTA]-[MLI]-[SGA]-[KS]-[SA]" in entry P07813 (individually applies ""KMSKS" region")
    • Subsequence at position 622 - 622 aligns to "K" in entry P07813 (individually applies "ATP")
    • taxon = Archaea
    • Subsequence at position 41 - 51 aligns to "P-Y-x-[SN]-[GAS]-x(2)-H-[LIVMA]-G-[HS]" in entry Q58050 (individually applies ""HIGH" region")
    • Subsequence at position 633 - 637 aligns to entry Q58050 (individually applies ""KMSKS" region")
    • Subsequence at position 636 - 636 aligns to "K" in entry Q58050 (individually applies "ATP")

... then these annotations are applied i

Protein namei

  • Recommended name:
    Leucine--tRNA ligase (EC:6.1.1.4)
    Alternative name(s):
    Leucyl-tRNA synthetase
    Short name:
    LeuRS

Gene namei

  • Name:leuS

Catalytic activityi

  • ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).

Subcellular locationi

Sequence similaritiesi

Binding sitei

  • ATP (to residues corresponding to position 622)
  • ATP (to residues corresponding to position 636)

Motifi

  • "HIGH" region (to residues corresponding to positions 42 - 52)
  • "KMSKS" region (to residues corresponding to positions 619 - 623)
  • "HIGH" region (to residues corresponding to positions 41 - 51)
  • "KMSKS" region (to residues corresponding to positions 633 - 637)

Keywordsi

GO (Gene Ontology) termsi

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