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The annotation and conditions in this rule are derived from the following entries: P0A7D4 (PURA_ECOLI)

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 39 - 42 aligns to "N-[AS]-G-H" in entry P0A7D4 (individually applies "IMP binding")
    • Subsequence at position 41 - 43 aligns to "G-H-x" in entry P0A7D4 (individually applies "GTP")
    • Subsequence at position 14 - 14 aligns to "D" in entry P0A7D4 (individually applies "Proton acceptor")
    • Subsequence at position 415 - 417 aligns to "x-x-[GS]" in entry P0A7D4 (individually applies "GTP")
    • Subsequence at position 13 - 19 aligns to "G-D-E-[GA]-K-[GA]-x" in entry P0A7D4 (individually applies "GTP")
    • Subsequence at position 14 - 17 aligns to "D-E-[GA]-K" in entry P0A7D4 (individually applies "IMP binding")
    • Subsequence at position 14 - 14 aligns to "D" in entry P0A7D4 (individually applies "Magnesium")
    • Subsequence at position 42 - 42 aligns to "H" in entry P0A7D4 (individually applies "Proton donor")
    • Subsequence at position 130 - 130 aligns to "T" in entry P0A7D4 (individually applies "IMP")
    • Subsequence at position 332 - 334 aligns to "x-x-D" in entry P0A7D4 (individually applies "GTP")
    • Subsequence at position 41 - 41 aligns to "G" in entry P0A7D4 (individually applies "Magnesium; via carbonyl oxygen")
    • Subsequence at position 240 - 240 aligns to "T" in entry P0A7D4 (individually applies "IMP")
    • Subsequence at position 304 - 304 aligns to "[KR]" in entry P0A7D4 (individually applies "IMP")
    • Subsequence at position 144 - 144 aligns to "[KR]" in entry P0A7D4 (individually applies "IMP; shared with dimeric partner")
    • Subsequence at position 225 - 225 aligns to "[QN]" in entry P0A7D4 (individually applies "IMP")
    • Subsequence at position 300 - 306 aligns to "x-x-[ST]-x-[KR]-x-R" in entry P0A7D4 (individually applies "Substrate binding")
    • Subsequence at position 306 - 306 aligns to "R" in entry P0A7D4 (individually applies "GTP")

... then these annotations are applied i

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namei

  • Recommended name:
    Adenylosuccinate synthetase (EC:6.3.4.4)
    Short name:
    AMPSase
    Short name:
    AdSS
    Alternative name(s):
    IMP--aspartate ligase

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namei

  • Name:purA

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi

  • Pathwayi: AMP biosynthesis via de novo pathway

    This protein is involved in step 1 of the subpathway that synthesizes AMP from IMP. This subpathway is part of the pathway AMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from IMP, the pathway AMP biosynthesis via de novo pathway and in Purine metabolism.

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

  • Homodimer.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> describes the function(s) of a protein.<p><a href='/help/function' target='_top'>More...</a></p>Functioni

  • Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei

  • IMP (to residues corresponding to position 130)
  • IMP (to residues corresponding to position 240)
  • IMP (to residues corresponding to position 304)
  • IMP; shared with dimeric partner (to residues corresponding to position 144)
  • IMP (to residues corresponding to position 225)
  • GTP (to residues corresponding to position 306)

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi

  • Magnesium (to residues corresponding to position 14)
  • Magnesium; via carbonyl oxygen (to residues corresponding to position 41)

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei

  • Proton acceptor (to residues corresponding to position 14)
  • Proton donor (to residues corresponding to position 42)

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi

  • GTP (to residues corresponding to positions 41 - 43)
  • GTP (to residues corresponding to positions 415 - 417)
  • GTP (to residues corresponding to positions 13 - 19)
  • GTP (to residues corresponding to positions 332 - 334)

<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni

  • IMP binding (to residues corresponding to positions 39 - 42)
  • IMP binding (to residues corresponding to positions 14 - 17)
  • Substrate binding (to residues corresponding to positions 300 - 306)

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO (Gene Ontology) termsi

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