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The annotation and conditions in this rule are derived from the following entries: P17854 (CYSH_ECOLI), O05927 (CYSH_PSEAE), P9WIK3 (CYSH_MYCTU), P56891 (CYSH_RHIME), P94498 (CYSH1_BACSU), A0R0W2 (CYSH_MYCS2)

If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_00063
    • taxon = Bacteria
    • fragment ≠ the sequence is fragmented

Special conditions

    • Subsequence at position 139 - 139 aligns to "C" in entry O05927 Subsequence at position 140 - 140 aligns to "C" in entry O05927 Subsequence at position 231 - 231 aligns to "C" in entry O05927 Subsequence at position 228 - 228 aligns to "C" in entry O05927
    • Subsequence at position 139 - 139 does not align to "C" in entry O05927 Subsequence at position 140 - 140 does not align to "C" in entry O05927 Subsequence at position 231 - 231 does not align to "C" in entry O05927 Subsequence at position 228 - 228 does not align to "C" in entry O05927
  • Subsequence at position 139 - 139 aligns to "C" in entry O05927 (applies "Iron-sulfur (4Fe-4S)") Subsequence at position 140 - 140 aligns to "C" in entry O05927 (applies "Iron-sulfur (4Fe-4S)") Subsequence at position 231 - 231 aligns to "C" in entry O05927 (applies "Iron-sulfur (4Fe-4S)") Subsequence at position 228 - 228 aligns to "C" in entry O05927 (applies "Iron-sulfur (4Fe-4S)")
    • Subsequence at position 256 - 256 aligns to "C" in entry O05927

... then these annotations are applied i

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi

  • Recommended name:
    Adenosine 5'-phosphosulfate reductase (EC:1.8.4.10)
    Short name:
    APS reductase
    Alternative name(s):
    5'-adenylylsulfate reductase
    Thioredoxin-dependent 5'-adenylylsulfate reductase
  • Recommended name:
    Phosphoadenosine 5'-phosphosulfate reductase (EC:1.8.4.8)
    Short name:
    PAPS reductase
    Alternative name(s):
    3'-phosphoadenylylsulfate reductase
    PAPS reductase, thioredoxin dependent
    PAPS sulfotransferase
    PAdoPS reductase

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namei

  • Name:cysH

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> describes the function(s) of a protein.<p><a href='/help/function' target='_top'>More...</a></p>Functioni

  • Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
  • Catalyzes the formation of sulfite from phosphoadenosine 5'-phosphosulfate (PAPS) using thioredoxin as an electron donor.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi

  • Pathwayi: hydrogen sulfide biosynthesis

    This protein is involved in the subpathway that synthesizes sulfite from sulfate. This subpathway is part of the pathway hydrogen sulfide biosynthesis, which is itself part of Sulfur metabolism.
    View all proteins of this organism that are known to be involved in the pathway hydrogen sulfide biosynthesis and in Sulfur metabolism.
  • Pathwayi: hydrogen sulfide biosynthesis

    This protein is involved in step 3 of the subpathway that synthesizes sulfite from sulfate. This subpathway is part of the pathway hydrogen sulfide biosynthesis, which is itself part of Sulfur metabolism.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes sulfite from sulfate, the pathway hydrogen sulfide biosynthesis and in Sulfur metabolism.

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi

  • Iron-sulfur (4Fe-4S) (to residues corresponding to position 139)
  • Iron-sulfur (4Fe-4S) (to residues corresponding to position 140)
  • Iron-sulfur (4Fe-4S) (to residues corresponding to position 231)
  • Iron-sulfur (4Fe-4S) (to residues corresponding to position 228)

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei

  • Nucleophile; cysteine thiosulfonate intermediate (to residues corresponding to position 256)

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO (Gene Ontology) termsi

  • GO:0004604 phosphoadenylyl-sulfate reductase (thioredoxin) activity
  • GO:0005737 cytoplasm
  • GO:0019379 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)
  • GO:0051539 4 iron, 4 sulfur cluster binding
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