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The annotation and conditions in this rule are derived from the following entries: P18133 (PNCB_ECOLI)

If a protein meets these conditions... i

Common conditions

... then these annotations are applied i

Protein namei

  • Recommended name:
    Nicotinate phosphoribosyltransferase (EC:
    Short name:

Gene namei

  • Name:pncB


  • Pathwayi: NAD(+) biosynthesis

    This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate. This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.


  • Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.

Catalytic activityi

  • Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.

Sequence similaritiesi


GO (Gene Ontology) termsi

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