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The annotation and conditions in this rule are derived from the following entries: O30297 (NADK_ARCFU), Q8Y8D7 (NADK1_LISMO), P9WHV7 (NADK_MYCTU), P0A7B3 (NADK_ECOLI), O58801 (NADK_PYRHO), O31612 (NADK1_BACSU), P65774 (NADK_SALTY), Q58327 (NPPNK_METJA)

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 145 - 145 aligns to "[DN]" in entry O30297 (individually applies "NAD")
    • Subsequence at position 180 - 180 aligns to "[ALV]" in entry O30297 (individually applies "NAD; via carbonyl oxygen")
    • Subsequence at position 115 - 116 aligns to "[NDE]-[ED]" in entry O30297 (individually applies "NAD")
    • Subsequence at position 49 - 50 aligns to "[DN]-[GA]" in entry O30297 (individually applies "NAD")
    • Subsequence at position 49 - 49 aligns to "[DN]" in entry O30297 (individually applies "Proton acceptor")
    • Subsequence at position 126 - 126 aligns to "[KHR]" in entry O30297 (individually applies "NAD")
    • Subsequence at position 153 - 153 aligns to "[ILVA]" in entry O30297 (individually applies "NAD; via carbonyl oxygen")
    • Subsequence at position 143 - 143 aligns to "[RKH]" in entry O30297 (individually applies "NAD")
    • Subsequence at position 156 - 161 aligns to "[TS]-x-[YHW]-x-x-S" in entry O30297 (individually applies "NAD")
    • Subsequence at position 211 - 211 aligns to "[QN]" in entry O30297 (individually applies "NAD")
    • Subsequence at position 54 - 54 aligns to "[RKH]" in entry O30297 (individually applies "NAD")

... then these annotations are applied i

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namei

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namei

  • Name:nadK

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> describes the function(s) of a protein.<p><a href='/help/function' target='_top'>More...</a></p>Functioni

  • Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei

  • NAD (to residues corresponding to position 145)
  • NAD; via carbonyl oxygen (to residues corresponding to position 180)
  • NAD (to residues corresponding to position 126)
  • NAD; via carbonyl oxygen (to residues corresponding to position 153)
  • NAD (to residues corresponding to position 143)
  • NAD (to residues corresponding to position 211)
  • NAD (to residues corresponding to position 54)

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi

  • NAD (to residues corresponding to positions 115 - 116)
  • NAD (to residues corresponding to positions 49 - 50)
  • NAD (to residues corresponding to positions 156 - 161)

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei

  • Proton acceptor (to residues corresponding to position 49)

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO (Gene Ontology) termsi

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