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The annotation and conditions in this rule are derived from the following entries: P62623 (ISPH_ECOLI), O67625 (ISPH_AQUAE), Q55643 (ISPH_SYNY3)

If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_00191
    • taxon = Bacteria
    • fragment ≠ the sequence is fragmented

Special conditions

    • Subsequence at position 12 - 12 aligns to "C" in entry P62623 Subsequence at position 96 - 96 aligns to "C" in entry P62623 Subsequence at position 197 - 197 aligns to "C" in entry P62623
  • Subsequence at position 12 - 12 aligns to "C" in entry P62623 (applies "Iron-sulfur (4Fe-4S)") Subsequence at position 96 - 96 aligns to "C" in entry P62623 (applies "Iron-sulfur (4Fe-4S)") Subsequence at position 197 - 197 aligns to "C" in entry P62623 (applies "Iron-sulfur (4Fe-4S)")
    • Subsequence at position 41 - 41 aligns to "H" in entry P62623 (individually applies "Substrate")
    • Subsequence at position 124 - 124 aligns to "H" in entry P62623 (individually applies "Substrate")
    • Subsequence at position 74 - 74 aligns to "H" in entry P62623 (individually applies "Substrate")
    • Subsequence at position 269 - 269 aligns to "S" in entry P62623 (individually applies "Substrate")
    • Subsequence at position 167 - 167 aligns to "[TS]" in entry P62623 (individually applies "Substrate")
    • Subsequence at position 126 - 126 aligns to "E" in entry P62623 (individually applies "Proton donor")
    • Subsequence at position 225 - 227 aligns to "S-x-N" in entry P62623 (individually applies "Substrate binding")

... then these annotations are applied i

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namei

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namei

  • Name:ispH

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

  • Homodimer.

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> describes the function(s) of a protein.<p><a href='/help/function' target='_top'>More...</a></p>Functioni

  • Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni

  • Substrate binding (to residues corresponding to positions 225 - 227)

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei

  • Proton donor (to residues corresponding to position 126)

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei

  • Substrate (to residues corresponding to position 41)
  • Substrate (to residues corresponding to position 124)
  • Substrate (to residues corresponding to position 74)
  • Substrate (to residues corresponding to position 269)
  • Substrate (to residues corresponding to position 167)

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi

  • Iron-sulfur (4Fe-4S) (to residues corresponding to position 12)
  • Iron-sulfur (4Fe-4S) (to residues corresponding to position 96)
  • Iron-sulfur (4Fe-4S) (to residues corresponding to position 197)

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO (Gene Ontology) termsi

  • GO:0016114 terpenoid biosynthetic process
  • GO:0019288 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
  • GO:0050992 dimethylallyl diphosphate biosynthetic process
  • GO:0051745 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity
  • GO:0051539 4 iron, 4 sulfur cluster binding
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