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The annotation and conditions in this rule are derived from the following entries: P05637 (APAH_ECOLI)

If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_00199
    • taxon = Bacteria
    • fragment ≠ the sequence is fragmented

... then these annotations are applied i

Protein namei

  • Recommended name:
    Bis(5'-nucleosyl)-tetraphosphatase, symmetrical (EC:
    Alternative name(s):
    Ap4A hydrolase
    Diadenosine tetraphosphatase
    Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase

Gene namei

  • Name:apaH

Catalytic activityi

  • P1,P4-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP.


  • Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.

Sequence similaritiesi


GO (Gene Ontology) termi

  • GO:0008803 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity
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