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The annotation and conditions in this rule are derived from the following entries: P43341 (LPXH_ECOLI), P44046 (LPXH_HAEIN), Q9I2V0 (LPXH_PSEAE)

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 8 - 8 aligns to "D" in entry Q9I2V0 (individually applies "Manganese 1")
    • Subsequence at position 10 - 10 aligns to "H" in entry Q9I2V0 (individually applies "Manganese 1; via tele nitrogen")
    • Subsequence at position 41 - 41 aligns to "D" in entry Q9I2V0 (individually applies "Manganese 1")
    • Subsequence at position 41 - 41 aligns to "D" in entry Q9I2V0 (individually applies "Manganese 2")
    • Subsequence at position 79 - 79 aligns to "N" in entry Q9I2V0 (individually applies "Manganese 2")
    • Subsequence at position 79 - 80 aligns to "N-[RH]" in entry Q9I2V0 (individually applies "Substrate binding")
    • Subsequence at position 114 - 114 aligns to "H" in entry Q9I2V0 (individually applies "Manganese 2; via tele nitrogen")
    • Subsequence at position 122 - 122 aligns to "D" in entry Q9I2V0 (individually applies "Substrate")
    • Subsequence at position 160 - 160 aligns to "S" in entry Q9I2V0 (individually applies "Substrate")
    • Subsequence at position 164 - 164 aligns to "[TKNQED]" in entry Q9I2V0 (individually applies "Substrate")
    • Subsequence at position 167 - 167 aligns to "[KRQN]" in entry Q9I2V0 (individually applies "Substrate")
    • Subsequence at position 195 - 195 aligns to "H" in entry Q9I2V0 (individually applies "Substrate; via tele nitrogen")
    • Subsequence at position 195 - 195 aligns to "H" in entry Q9I2V0 (individually applies "Manganese 2; via pros nitrogen")
    • Subsequence at position 197 - 197 aligns to "H" in entry Q9I2V0 (individually applies "Manganese 1; via tele nitrogen")

... then these annotations are applied i

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namei

  • Recommended name:
    UDP-2,3-diacylglucosamine hydrolase (EC:3.6.1.54)
    Alternative name(s):
    UDP-2,3-diacylglucosamine diphosphatase

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namei

  • Name:lpxH

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

<p>This section describes the function(s) of a protein.<p><a href='/help/function' target='_top'>More...</a></p>Functioni

  • Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

  • Mn2+Note: Binds 2 Mn2+ ions per subunit in a binuclear metal center.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei

  • Substrate (to residues corresponding to position 122)
  • Substrate (to residues corresponding to position 160)
  • Substrate (to residues corresponding to position 164)
  • Substrate (to residues corresponding to position 167)
  • Substrate; via tele nitrogen (to residues corresponding to position 195)

<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni

  • Substrate binding (to residues corresponding to positions 79 - 80)

<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi

  • Manganese 1 (to residues corresponding to position 8)
  • Manganese 1; via tele nitrogen (to residues corresponding to position 10)
  • Manganese 1 (to residues corresponding to position 41)
  • Manganese 2 (to residues corresponding to position 41)
  • Manganese 2 (to residues corresponding to position 79)
  • Manganese 2; via tele nitrogen (to residues corresponding to position 114)
  • Manganese 2; via pros nitrogen (to residues corresponding to position 195)
  • Manganese 1; via tele nitrogen (to residues corresponding to position 197)

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO (Gene Ontology) termsi

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