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The annotation and conditions in this rule are derived from the following entries: P11498 (PYC_HUMAN), P32327 (PYC2_YEAST), Q9KWU4 (PYC_BACSU)

If a protein meets these conditions... i

Common conditions

    • Matches PIR Superfamily signature PIRSF001594
    • sequence length = 1103 - 1238
    • taxon = Eukaryota, Bacteria
    • fragment ≠ the sequence is fragmented

... then these annotations are applied i

Protein namei

  • Recommended name:
    Pyruvate carboxylase (EC:

Catalytic activityi

  • ATP + pyruvate + HCO3- = ADP + phosphate + oxaloacetate.


  • Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.



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