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The annotation and conditions in this rule are derived from the following entries: P77488 (DXS_ECOLI), Q9RUB5 (DXS_DEIRA)

If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_00315
    • taxon = Bacteria
    • fragment ≠ the sequence is fragmented

Special conditions

    • Subsequence at position 181 - 181 aligns to "N" in entry P77488 (individually applies "Magnesium")
    • Subsequence at position 80 - 80 aligns to "H" in entry P77488 (individually applies "Thiamine pyrophosphate")
    • Subsequence at position 288 - 288 aligns to "[YFH]" in entry P77488 (individually applies "Thiamine pyrophosphate")
    • Subsequence at position 121 - 123 aligns to "[GAS]-x-[SAT]" in entry P77488 (individually applies "Thiamine pyrophosphate binding")
    • Subsequence at position 181 - 181 aligns to "N" in entry P77488 (individually applies "Thiamine pyrophosphate")
    • Subsequence at position 370 - 370 aligns to "E" in entry P77488 (individually applies "Thiamine pyrophosphate")
    • Subsequence at position 152 - 152 aligns to "D" in entry P77488 (individually applies "Magnesium")
    • Subsequence at position 153 - 154 aligns to "[GA]-[ASTG]" in entry P77488 (individually applies "Thiamine pyrophosphate binding")

... then these annotations are applied i

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namei

  • Recommended name:
    1-deoxy-D-xylulose-5-phosphate synthase (EC:2.2.1.7)
    Alternative name(s):
    1-deoxyxylulose-5-phosphate synthase
    Short name:
    DXP synthase
    Short name:
    DXPS

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namei

  • Name:dxs

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> describes the function(s) of a protein.<p><a href='/help/function' target='_top'>More...</a></p>Functioni

  • Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

  • Homodimer.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi

<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni

  • Thiamine pyrophosphate binding (to residues corresponding to positions 121 - 123)
  • Thiamine pyrophosphate binding (to residues corresponding to positions 153 - 154)

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei

  • Thiamine pyrophosphate (to residues corresponding to position 80)
  • Thiamine pyrophosphate (to residues corresponding to position 288)
  • Thiamine pyrophosphate (to residues corresponding to position 181)
  • Thiamine pyrophosphate (to residues corresponding to position 370)

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi

  • Magnesium (to residues corresponding to position 181)
  • Magnesium (to residues corresponding to position 152)

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO (Gene Ontology) termsi

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