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The annotation and conditions in this rule are derived from the following entries: P05055 (PNP_ECOLI), Q8ZLT3 (PNP_SALTY), P50849 (PNP_BACSU), Q53597 (PNP_STRAT)

If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_01595
    • taxon = Bacteria
    • fragment ≠ the sequence is fragmented

Special conditions

    • Subsequence at position 486 - 486 aligns to "D" in entry P05055 (individually applies "Magnesium")
    • Subsequence at position 492 - 492 aligns to "D" in entry P05055 (individually applies "Magnesium")

... then these annotations are applied i

Protein namei

  • Recommended name:
    Polyribonucleotide nucleotidyltransferase (EC:
    Alternative name(s):
    Polynucleotide phosphorylase
    Short name:

Gene namei

  • Name:pnp

Catalytic activityi

  • RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.


  • Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.


Subcellular locationi

Sequence similaritiesi

Subunit structurei

  • Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.

Metal bindingi

  • Magnesium (to residues corresponding to position 486)
  • Magnesium (to residues corresponding to position 492)


GO (Gene Ontology) termsi

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