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UniProtKB - Z4YK94 (Z4YK94_MOUSE)
Protein
Tumor protein p73
Gene
Trp73
Organism
Mus musculus (Mouse)
Status
Functioni
Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.
UniRule annotationCofactori
Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
- identical protein binding Source: Ensembl
- MDM2/MDM4 family protein binding Source: Ensembl
- metal ion binding Source: UniProtKB-KW
- p53 binding Source: Ensembl
- protein kinase binding Source: Ensembl
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
- RNA polymerase II-specific DNA-binding transcription factor binding Source: Ensembl
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
- kidney development Source: Ensembl
- negative regulation of cardiac muscle cell proliferation Source: Ensembl
- negative regulation of neuron differentiation Source: Ensembl
- negative regulation of signal transduction Source: UniProt
- positive regulation of apoptotic process Source: Ensembl
- positive regulation of MAPK cascade Source: Ensembl
- positive regulation of oligodendrocyte differentiation Source: Ensembl
- protein tetramerization Source: InterPro
- regulation of apoptotic signaling pathway Source: UniProt
- regulation of mitotic cell cycle Source: Ensembl
- response to organonitrogen compound Source: Ensembl
- response to xenobiotic stimulus Source: Ensembl
Keywordsi
Molecular function | ActivatorUniRule annotationARBA annotation, DNA-bindingUniRule annotation |
Biological process | ApoptosisUniRule annotationARBA annotation, Cell cycleUniRule annotation, Transcription, Transcription regulationUniRule annotation |
Ligand | Metal-bindingUniRule annotationARBA annotation, ZincUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Tumor protein p73UniRule annotation |
Gene namesi | Name:Trp73Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1336991, Trp73 |
VEuPathDBi | HostDB:ENSMUSG00000029026 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus Source: Ensembl
Nucleus
- nucleoplasm Source: Ensembl
Other locations
- cell junction Source: Ensembl
- chromatin Source: Ensembl
Keywords - Cellular componenti
CytoplasmUniRule annotation, NucleusUniRule annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000029026, Expressed in cerebral cortex and 106 other tissues |
Interactioni
Subunit structurei
Found in a complex with p53/TP53 and CABLES1.
UniRule annotationGO - Molecular functioni
- identical protein binding Source: Ensembl
- MDM2/MDM4 family protein binding Source: Ensembl
- p53 binding Source: Ensembl
- protein kinase binding Source: Ensembl
- RNA polymerase II-specific DNA-binding transcription factor binding Source: Ensembl
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 486 – 552 | SAMInterPro annotationAdd BLAST | 67 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 50 | DisorderedSequence analysisAdd BLAST | 50 | |
Regioni | 76 – 120 | DisorderedSequence analysisAdd BLAST | 45 | |
Regioni | 313 – 341 | DisorderedSequence analysisAdd BLAST | 29 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 95 – 114 | Polar residuesSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00950000183153 |
OMAi | FQHLWSS |
OrthoDBi | 257530at2759 |
Family and domain databases
CDDi | cd08367, P53, 1 hit cd09571, SAM_tumor-p73, 1 hit |
Gene3Di | 1.10.150.50, 1 hit 2.60.40.720, 1 hit 4.10.170.10, 1 hit |
InterProi | View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR012346, p53/RUNT-type_TF_DNA-bd_sf IPR011615, p53_DNA-bd IPR036674, p53_tetramer_sf IPR010991, p53_tetrameristn IPR002117, p53_tumour_suppressor IPR001660, SAM IPR013761, SAM/pointed_sf IPR032646, Tp73 IPR037612, Tumour-p73_SAM |
PANTHERi | PTHR11447, PTHR11447, 1 hit PTHR11447:SF21, PTHR11447:SF21, 1 hit |
Pfami | View protein in Pfam PF00870, P53, 1 hit PF07710, P53_tetramer, 1 hit PF07647, SAM_2, 1 hit |
PRINTSi | PR00386, P53SUPPRESSR |
SMARTi | View protein in SMART SM00454, SAM, 1 hit |
SUPFAMi | SSF47719, SSF47719, 1 hit SSF47769, SSF47769, 1 hit SSF49417, SSF49417, 1 hit |
PROSITEi | View protein in PROSITE PS00348, P53, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Z4YK94-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGSVGEMAQ TSSSSSSTFE HLWSSLEPDS TYFDLPQPSQ GTSEASGSEE
60 70 80 90 100
SNMDVFHLQG MAQFNLLSSA MDQMGSRAAP ASPYTPEHAA SAPTHSPYAQ
110 120 130 140 150
PSSTFDTMSP APVIPSNTDY PGPHHFEVTF QQSSTAKSAT WTYSPLLKKL
160 170 180 190 200
YCQIAKTCPI QIKVSTPPPP GTAIRAMPVY KKAEHVTDIV KRCPNHELGR
210 220 230 240 250
DFNEGQSAPA SHLIRVEGNN LAQYVDDPVT GRQSVVVPYE PPQVGTEFTT
260 270 280 290 300
ILYNFMCNSS CVGGMNRRPI LVIITLETRD GQVLGRRSFE GRICACPGRD
310 320 330 340 350
RKADEDHYRE QQALNESTTK NGAASKRAFK QSPPAIPALG TNVKKRRHGD
360 370 380 390 400
EDMFYMHVRG RENFEILMKV KESLELMELV PQPLVDSYRQ QQQQQLLQRP
410 420 430 440 450
SHLQPPSYGP VLSPMNKVHG GVNKLPSVNQ LVGQPPPHSS AAGPNLGPMG
460 470 480 490 500
SGMLNSHGHS MPANGEMNGG HSSQTMVSGS HCTPPPPYHA DPSLVSFLTG
510 520 530 540 550
LGCPNCIECF TSQGLQSIYH LQNLTIEDLG ALKVPDQYRM TIWRGLQDLK
560 570 580 590 600
QSHDCGQQLL RSSSNAATIS IGGSGELQRQ RVMEAVHFRV RHTITIPNRG
610 620 630
GAGAVTGPDE WADFGFDLPD CKSRKQPIKE EFTETESH
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9JJP2 | P73_MOUSE | Tumor protein p73 | Tp73 P73, Trp73 | 631 | Annotation score: | ||
G3UYS2 | G3UYS2_MOUSE | Cellular tumor antigen p53 | Trp73 | 367 | Annotation score: | ||
H3BK76 | H3BK76_MOUSE | Cellular tumor antigen p53 | Trp73 | 213 | Annotation score: | ||
B1AX91 | B1AX91_MOUSE | Transformation-related protein 73 | Trp73 | 204 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL806525 Genomic DNA No translation available. |
RefSeqi | NP_035772.2, NM_011642.3 |
Genome annotation databases
Ensembli | ENSMUST00000105644; ENSMUSP00000101269; ENSMUSG00000029026 ENSMUST00000239448; ENSMUSP00000159346; ENSMUSG00000029026 |
GeneIDi | 22062 |
KEGGi | mmu:22062 |
UCSCi | uc008wbh.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL806525 Genomic DNA No translation available. |
RefSeqi | NP_035772.2, NM_011642.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 3467, 1141 antibodies from 43 providers |
DNASUi | 22062 |
Genome annotation databases
Ensembli | ENSMUST00000105644; ENSMUSP00000101269; ENSMUSG00000029026 ENSMUST00000239448; ENSMUSP00000159346; ENSMUSG00000029026 |
GeneIDi | 22062 |
KEGGi | mmu:22062 |
UCSCi | uc008wbh.2, mouse |
Organism-specific databases
CTDi | 22062 |
MGIi | MGI:1336991, Trp73 |
VEuPathDBi | HostDB:ENSMUSG00000029026 |
Phylogenomic databases
GeneTreei | ENSGT00950000183153 |
OMAi | FQHLWSS |
OrthoDBi | 257530at2759 |
Miscellaneous databases
BioGRID-ORCSi | 22062, 1 hit in 64 CRISPR screens |
ChiTaRSi | Trp73, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000029026, Expressed in cerebral cortex and 106 other tissues |
Family and domain databases
CDDi | cd08367, P53, 1 hit cd09571, SAM_tumor-p73, 1 hit |
Gene3Di | 1.10.150.50, 1 hit 2.60.40.720, 1 hit 4.10.170.10, 1 hit |
InterProi | View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR012346, p53/RUNT-type_TF_DNA-bd_sf IPR011615, p53_DNA-bd IPR036674, p53_tetramer_sf IPR010991, p53_tetrameristn IPR002117, p53_tumour_suppressor IPR001660, SAM IPR013761, SAM/pointed_sf IPR032646, Tp73 IPR037612, Tumour-p73_SAM |
PANTHERi | PTHR11447, PTHR11447, 1 hit PTHR11447:SF21, PTHR11447:SF21, 1 hit |
Pfami | View protein in Pfam PF00870, P53, 1 hit PF07710, P53_tetramer, 1 hit PF07647, SAM_2, 1 hit |
PRINTSi | PR00386, P53SUPPRESSR |
SMARTi | View protein in SMART SM00454, SAM, 1 hit |
SUPFAMi | SSF47719, SSF47719, 1 hit SSF47769, SSF47769, 1 hit SSF49417, SSF49417, 1 hit |
PROSITEi | View protein in PROSITE PS00348, P53, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Z4YK94_MOUSE | |
Accessioni | Z4YK94Primary (citable) accession number: Z4YK94 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 11, 2014 |
Last sequence update: | June 11, 2014 | |
Last modified: | January 19, 2022 | |
This is version 56 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |