Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

NPC1-like 1

Gene

Npc1l1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-8963678 Intestinal lipid absorption

Names & Taxonomyi

Protein namesi
Submitted name:
NPC1-like 1Imported
Submitted name:
NPC1-like intracellular cholesterol transporter 1Imported
Gene namesi
Name:Npc1l1Imported
ORF Names:mCG_21405Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2685089 Npc1l1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei283 – 305HelicalSequence analysisAdd BLAST23
Transmembranei348 – 373HelicalSequence analysisAdd BLAST26
Transmembranei633 – 654HelicalSequence analysisAdd BLAST22
Transmembranei666 – 690HelicalSequence analysisAdd BLAST25
Transmembranei696 – 719HelicalSequence analysisAdd BLAST24
Transmembranei740 – 766HelicalSequence analysisAdd BLAST27
Transmembranei772 – 797HelicalSequence analysisAdd BLAST26
Transmembranei844 – 863HelicalSequence analysisAdd BLAST20
Transmembranei1113 – 1132HelicalSequence analysisAdd BLAST20
Transmembranei1139 – 1160HelicalSequence analysisAdd BLAST22
Transmembranei1166 – 1186HelicalSequence analysisAdd BLAST21
Transmembranei1207 – 1231HelicalSequence analysisAdd BLAST25
Transmembranei1243 – 1266HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_501510302121 – 1333Sequence analysisAdd BLAST1313

Expressioni

Gene expression databases

BgeeiENSMUSG00000020447

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini632 – 797SSDInterPro annotationAdd BLAST166

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1933 Eukaryota
ENOG410XR54 LUCA
GeneTreeiENSGT00900000140845
KOiK14461
OMAiKDEFCPS
OrthoDBiEOG091G00JD

Family and domain databases

InterProiView protein in InterPro
IPR004765 NPC1-like
IPR032190 NPC1_N
IPR003392 Ptc/Disp
IPR000731 SSD
PfamiView protein in Pfam
PF16414 NPC1_N, 1 hit
PF02460 Patched, 1 hit
PF12349 Sterol-sensing, 1 hit
TIGRFAMsiTIGR00917 2A060601, 1 hit
PROSITEiView protein in PROSITE
PS50156 SSD, 1 hit

Sequencei

Sequence statusi: Complete.

Z4YJC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAWQGWLL WALLLNSAQG ELYTPTHKAG FCTFYEECGK NPELSGGLTS
60 70 80 90 100
LSNISCLSNT PARHVTGDHL ALLQRVCPRL YNGPNDTYAC CSTKQLVSLD
110 120 130 140 150
SSLSITKALL TRCPACSENF VSIHCHNTCS PDQSLFINVT RVVQRDPGQL
160 170 180 190 200
PAVVAYEAFY QRSFAEKAYE SCSRVRIPAA ASLAVGSMCG VYGSALCNAQ
210 220 230 240 250
RWLNFQGDTG NGLAPLDITF HLLEPGQALA DGMKPLDGKI TPCNESQGED
260 270 280 290 300
SAACSCQDCA ASCPVIPPPP ALRPSFYMGR MPGWLALIII FTAVFVLLSV
310 320 330 340 350
VLVYLRVASN RNKNKTAGSQ EAPNLPRKRR FSPHTVLGRF FESWGTRVAS
360 370 380 390 400
WPLTVLALSF IVVIALSVGL TFIELTTDPV ELWSAPKSQA RKEKAFHDEH
410 420 430 440 450
FGPFFRTNQI FVTAKNRSSY KYDSLLLGPK NFSGILSLDL LQELLELQER
460 470 480 490 500
LRHLQVWSHE AQRNISLQDI CYAPLKPHNT SLTDCCVNSL LQYFQNNHTL
510 520 530 540 550
LLLTANQTLN GQTSLVDWKD HFLYCANAPL TYKDGTALAL SCIADYGAPV
560 570 580 590 600
FPFLAVGGYQ GTDYSEAEAL IITFSINNYP ADDPRMAHAK LWEEAFLKEM
610 620 630 640 650
QSFQRSTADK FQIAFSAERS LEDEINRTTI QDLPVFAISY LIVFLYISLA
660 670 680 690 700
LGSYSRWSRV AVDSKATLGL GGVAVVLGAV VAAMGFYSYL GVPSSLVIIQ
710 720 730 740 750
VVPFLVLAVG ADNIFIFVLE YQRLPRMPGE QREAHIGRTL GSVAPSMLLC
760 770 780 790 800
SLSEAICFFL GALTSMPAVR TFALTSGLAI IFDFLLQMTA FVALLSLDSK
810 820 830 840 850
RQEASRPDVV CCFSSRNLPP PKQKEGLLLC FFRKIYTPFL LHRFIRPVVL
860 870 880 890 900
LLFLVLFGAN LYLMCNISVG LDQDLALPKD SYLIDYFLFL NRYLEVGPPV
910 920 930 940 950
YFDTTSGYNF STEAGMNAIC SSAGCESFSL TQKIQYASEF PNQSYVAIAA
960 970 980 990 1000
SSWVDDFIDW LTPSSSCCRI YTRGPHKDEF CPSTDTSFNC LKNCMNRTLG
1010 1020 1030 1040 1050
PVRPTTEQFH KYLPWFLNDT PNIRCPKGGL AAYRTSVNLS SDGQIIASQF
1060 1070 1080 1090 1100
MAYHKPLRNS QDFTEALRAS RLLAANITAE LRKVPGTDPN FEVFPYTISN
1110 1120 1130 1140 1150
VFYQQYLTVL PEGIFTLALC FVPTFVVCYL LLGLDIRSGI LNLLSIIMIL
1160 1170 1180 1190 1200
VDTIGLMAVW GISYNAVSLI NLVTAVGMSV EFVSHITRSF AVSTKPTRLE
1210 1220 1230 1240 1250
RAKDATIFMG SAVFAGVAMT NFPGILILGF AQAQLIQIFF FRLNLLITLL
1260 1270 1280 1290 1300
GLLHGLVFLP VVLSYLGPDV NQALVLEEKL ATEAAMVSEP SCPQYPFPAD
1310 1320 1330
ANTSDYVNYG FNPEFIPEIN AASSSLPKSD QKF
Length:1,333
Mass (Da):147,146
Last modified:June 11, 2014 - v1
Checksum:i17B20DE6B5F0AF5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL607152 Genomic DNA No translation available.
CH466574 Genomic DNA Translation: EDL40576.1
RefSeqiNP_997125.2, NM_207242.2
UniGeneiMm.212492

Genome annotation databases

EnsembliENSMUST00000004505; ENSMUSP00000004505; ENSMUSG00000020447
GeneIDi237636
KEGGimmu:237636
UCSCiuc007hyb.2 mouse

Similar proteinsi

Entry informationi

Entry nameiZ4YJC9_MOUSE
AccessioniPrimary (citable) accession number: Z4YJC9
Entry historyiIntegrated into UniProtKB/TrEMBL: June 11, 2014
Last sequence update: June 11, 2014
Last modified: June 20, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health