UniProtKB - Z4YHY2 (Z4YHY2_DANRE)
Protein
Serine/threonine-protein kinase
Gene
pim2
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.UniRule annotation
Catalytic activityi
- EC:2.7.11.1ARBA annotation
- ATP + L-threonyl-[protein] = ADP + H+ + O-phospho-L-threonyl-[protein]UniRule annotationARBA annotationEC:2.7.11.1UniRule annotationARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 59 | ATPUniRule annotation | 1 | |
Binding sitei | 121 | ATP; via carbonyl oxygenUniRule annotation | 1 | |
Binding sitei | 128 | ATPUniRule annotation | 1 | |
Active sitei | 167 | Proton acceptorUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 36 – 44 | ATPUniRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- protein serine kinase activity Source: UniProtKB-EC
- protein threonine kinase activity Source: UniProtKB-EC
GO - Biological processi
- negative regulation of apoptotic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinaseUniRule annotation, Transferase |
Ligand | ATP-bindingUniRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:pim2Imported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-000831-6, pim2 |
Expressioni
Gene expression databases
Bgeei | ENSDARG00000059001, Expressed in granulocyte and 38 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 30 – 290 | Protein kinaseInterPro annotationAdd BLAST | 261 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.UniRule annotationARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00940000163427 |
HOGENOMi | CLU_000288_63_0_1 |
OMAi | QWARLPG |
OrthoDBi | 930292at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR017348, PIM1/2/3 IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
PIRSFi | PIRSF037993, STPK_Pim-1, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Z4YHY2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLDKRIVDVR LDQLEILKAK NGKEHFEKQY TMGNLLGSGG FGSVYSGHRI
60 70 80 90 100
SDGQKVAIKQ ISRDRIQQWS KMPGEVNPVP NEIALLQSLG GGSGSVPGHR
110 120 130 140 150
GIIRMLDWFE IPGQEYLIVF EKPQHCQDLF DFITERGALD ESLARRFLKQ
160 170 180 190 200
VIEAVQFCHS KGIVHRDIKD ENILVDTRTG DIKVIDFGSG ATLKDSMYTD
210 220 230 240 250
FEGTRVYSPP EWILYHKYHA LPLTVWSLGV LLYDMVCGDI PFEQDTDIVK
260 270 280 290 300
AKPSFNKRIS NDCRSLICSC LSFNPGDRPS LEQILQHPWM MESSVDNGDL
310
QEESKIKPSL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ9YHZ5 | PIM2_DANRE | Serine/threonine-protein kinase pim... | pim2 pim1, si:dkey-83k24.1 | 310 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR450685 Genomic DNA No translation available. |
RefSeqi | NP_571614.2, NM_131539.2 |
Genome annotation databases
Ensembli | ENSDART00000081985; ENSDARP00000076422; ENSDARG00000059001 |
GeneIDi | 58054 |
KEGGi | dre:58054 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR450685 Genomic DNA No translation available. |
RefSeqi | NP_571614.2, NM_131539.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSDART00000081985; ENSDARP00000076422; ENSDARG00000059001 |
GeneIDi | 58054 |
KEGGi | dre:58054 |
Organism-specific databases
CTDi | 11040 |
ZFINi | ZDB-GENE-000831-6, pim2 |
Phylogenomic databases
GeneTreei | ENSGT00940000163427 |
HOGENOMi | CLU_000288_63_0_1 |
OMAi | QWARLPG |
OrthoDBi | 930292at2759 |
Gene expression databases
Bgeei | ENSDARG00000059001, Expressed in granulocyte and 38 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR017348, PIM1/2/3 IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
PIRSFi | PIRSF037993, STPK_Pim-1, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Z4YHY2_DANRE | |
Accessioni | Z4YHY2Primary (citable) accession number: Z4YHY2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 11, 2014 |
Last sequence update: | June 11, 2014 | |
Last modified: | April 7, 2021 | |
This is version 43 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |