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Entry version 38 (08 May 2019)
Sequence version 1 (11 Jun 2014)
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Protein

Serine/threonine-protein kinase WNK

Gene

wnk-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine-protein kinase which phosphorylates gck-3 (PubMed:18049475). Plays a role in osmotic stress responses during which it increases gpdh-1 translation, likely by phosphorylating gck-3 (PubMed:23076791). Essential for larval development and the tubular formation of the excretory canals (PubMed:18049475).2 Publications

Caution

Was named WNK/'with no lysine(K)' because key residues for catalysis, including the lysine involved in ATP binding, are either not conserved or differ compared to the residues described in other kinase family proteins.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei344ATP; via amide nitrogenBy similarity1
Binding sitei466ATPBy similarity1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei483Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi416 – 419ATPBy similarity4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Kinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-2672351 Stimuli-sensing channels

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase WNKCurated (EC:2.7.11.11 Publication)
Alternative name(s):
Protein kinase with no lysine 11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:wnk-1Imported
ORF Names:C46C2.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...
WormBasei
C46C2.1a ; CE37331 ; WBGene00006941 ; wnk-1
C46C2.1b ; CE37332 ; WBGene00006941 ; wnk-1
C46C2.1c ; CE46706 ; WBGene00006941 ; wnk-1
C46C2.1d ; CE46603 ; WBGene00006941 ; wnk-1
C46C2.1e ; CE46553 ; WBGene00006941 ; wnk-1
C46C2.1f ; CE46627 ; WBGene00006941 ; wnk-1
C46C2.1g ; CE46722 ; WBGene00006941 ; wnk-1
C46C2.1h ; CE46797 ; WBGene00006941 ; wnk-1
C46C2.1i ; CE46749 ; WBGene00006941 ; wnk-1
C46C2.1j ; CE46831 ; WBGene00006941 ; wnk-1
C46C2.1k ; CE46763 ; WBGene00006941 ; wnk-1
C46C2.1l ; CE46557 ; WBGene00006941 ; wnk-1
C46C2.1m ; CE46636 ; WBGene00006941 ; wnk-1
C46C2.1n ; CE49690 ; WBGene00006941 ; wnk-1
C46C2.1o ; CE49733 ; WBGene00006941 ; wnk-1
C46C2.1p ; CE49626 ; WBGene00006941 ; wnk-1
C46C2.1q ; CE49684 ; WBGene00006941 ; wnk-1
C46C2.1r ; CE49717 ; WBGene00006941 ; wnk-1
C46C2.1s ; CE49622 ; WBGene00006941 ; wnk-1
C46C2.1t ; CE49653 ; WBGene00006941 ; wnk-1
C46C2.1u ; CE49693 ; WBGene00006941 ; wnk-1
C46C2.1v ; CE49732 ; WBGene00006941 ; wnk-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown causes impaired survival and slower volume recovery upon hypertonic stress.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi346K → M: No catalytic activity. Arrest at L2 larval stage and abnormal formation of the excretory canal. 1 Publication1
Mutagenesisi497S → A: No defect in the formation of the excretory canal. 1 Publication1
Mutagenesisi1133F → A: Severe loss of interaction with gck-3 and abnormal formation of the excretory canal; when associated with A-1222. 1 Publication1
Mutagenesisi1222F → A: Severe loss of interaction with gck-3 and abnormal formation of the excretory canal; when associated with A-1133. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004332181 – 1850Serine/threonine-protein kinase WNKCuratedAdd BLAST1850

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
X5M5N0

PeptideAtlas

More...
PeptideAtlasi
X5M5N0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in pharynx, nervous system, hypodermis, spermatheca, excretory cell and canal and body wall muscles.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00006941 Expressed in 5 organ(s), highest expression level in multi-cellular organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with gck-3 (via C-terminus).2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
gck-3G5EEN43EBI-6540721,EBI-7713242

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
X5M5N0, 2 interactors

Molecular INTeraction database

More...
MINTi
X5M5N0

STRING: functional protein association networks

More...
STRINGi
6239.C46C2.1m

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
X5M5N0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini334 – 596Protein kinasePROSITE-ProRule annotationAdd BLAST263

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili693 – 749Sequence analysisAdd BLAST57

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi750 – 859Pro-richPROSITE-ProRule annotationAdd BLAST110

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0584 Eukaryota
ENOG410XQWZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000171556

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000022086

KEGG Orthology (KO)

More...
KOi
K08867

Identification of Orthologs from Complete Genome Data

More...
OMAi
MDQECAQ

Database of Orthologous Groups

More...
OrthoDBi
695382at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR024678 Kinase_OSR1/WNK_CCT
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12202 OSR1_C, 1 hit
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (22)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 22 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform nImported (identifier: X5M5N0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPDSITNGGR PPAPPSSVSS TTASTTGNFG TRRRLVNRIK KVDELHPAQE
60 70 80 90 100
NPTMGSHWLS EQERSRLEAV QQDWRRTRPM KFQWTSKKRP DDPTTSSPST
110 120 130 140 150
VSISNALENS TPSLNNVSSI TNSSSPFSLS SAATSTASAI IPFTSNVATN
160 170 180 190 200
HPHLNHHVSR IPQAIVTGGT NGSLPPLLIS PTSAAAATPL ISGKAGPMSP
210 220 230 240 250
STGSPINVAA TVLQNAVSSP QHSIFDRSRL NKIPPNTSLA SSSSPSDAAN
260 270 280 290 300
NDKPIQQRHS ILSNVRTLTQ AMVNDGPRTL TGDDMDKMVS EEERARKEQE
310 320 330 340 350
KREEEEKAAR RIDVEDDFDA QEKPIDKSKN GRFLKFDEEL GRGSFKTVFR
360 370 380 390 400
GLDTETGVAV AWCELQESKL NKTERQRFRE EAEMLKDLQH PNIVRFYDYW
410 420 430 440 450
ESADLCGKRK YIVLVTELMT SGTLKMYLKR FKRINIKVLK SWCRQILKGL
460 470 480 490 500
SFLHTRNPPV IHRDLKCDNI FITGTTGSVK IGDLGLATLK NKSFAKSVIG
510 520 530 540 550
TPEFMAPEMY EEMYDESVDV YAFGMCLLEM VTGEYPYSEC MNPATIYRKV
560 570 580 590 600
ISGVKPECFS RIPAQYPEIR EIIDRCIRVR REERSTVKQL LVDDFFTPED
610 620 630 640 650
LIGIRVEIKN RDADLNDLNV EIQMQLRVYD EKKRKQYRFK ENEGLQFAFD
660 670 680 690 700
IENDSPDEVV QQMIEQQHIP DEDTRMITKL IKDKVDAFRR DRDHRLLEIK
710 720 730 740 750
RAKEEEERIR EEAEIKEELR LRAEAKEKEK ERLEKERLEK KAAAAAAANP
760 770 780 790 800
NPTPIPPTPA TPHSSAQQQP IPPPLSTQTS AEIQQSAQQP SVPVTMIANI
810 820 830 840 850
PAMSPTSAQP QPVLSPTSAA VPVPTTMIHV PKPSEIPVQN VATTAAPVAA
860 870 880 890 900
NNVPPSPAPF KTEDIQTPTL AQNTVPRTIS TDASGLVINT PASIASPSPA
910 920 930 940 950
PSATDVASTT APVTPAPTPT TTTDGGAAAA STTTENKEEK RKSNKRKVVM
960 970 980 990 1000
EILGCDESRN FALVSCRLDT SHKSVTFQFA PGTDKPCTIA TKLLAEDCLL
1010 1020 1030 1040 1050
KVHVHIVEAQ LGEVIQLINS DGKKGVGTKL ATVLDPNSTE PPTITAVMPK
1060 1070 1080 1090 1100
DSSAATASNT KPKIEIEKTP PTRDASQEPN NVQVTNVRKV SQESNAESVQ
1110 1120 1130 1140 1150
SIPRPGGIIV MSPTNQTDSA PPPTGAAAKP SRFQVTKSAD PIATPISSSI
1160 1170 1180 1190 1200
STATVIPIVA ATPTNITSEP VIVQPITAQV ITHLATPSPV SHSLSSNSSP
1210 1220 1230 1240 1250
SATTHSNMSS IQSTTSVPGR RFTVQPVSQA ESGISSSIST PHPEPTPAIT
1260 1270 1280 1290 1300
SCPPPVPSVP PVVSNGTLNL EVAPKQTPSA TNQNVDTQHS SSTASTATLV
1310 1320 1330 1340 1350
SETPATVHVT PISVPAPVQE PLVIDHHSDV LTQLDSELRK CFQVSGVSHS
1360 1370 1380 1390 1400
ASPSTVVESL TSMTPQTIPL ACQTVPASIG QAPAVIAAAH AASLIPNASV
1410 1420 1430 1440 1450
PQSPSRLDAE TGLAGLHEKL EALKMEQDRR EDMGDDAIGT TTTDGKDEIP
1460 1470 1480 1490 1500
IDTLKGLAEA LGKVIHADGR ETTPMPPDHP DLTDASTQQL ISPSNPDVLT
1510 1520 1530 1540 1550
TMSSAVEGSA SSTMIEDIDA STSAVDASMM NSMPPGAQNS TDQIPAAMTL
1560 1570 1580 1590 1600
SMDQECAQSM TSSITRNTTG TKLATFENLE TALSSTLGTH IRQPNAPSSR
1610 1620 1630 1640 1650
DETTAPMTPS FTNERIGGGG GGGATSFSIG TPPSHSPFPV SECDYDLKGQ
1660 1670 1680 1690 1700
MDLESEDPEV IQMIVRHRME QHKLLEKQRV EIERLRSKIR VPRATSVNPE
1710 1720 1730 1740 1750
MIGDDEADTT LTALQSALGN ASLSLPASPP PNTEIPDNEG QHHCNSFRCI
1760 1770 1780 1790 1800
GDPNDNVSIV NQIKQRLGII PSSRQSVRSA TSSSPSTPPS SSSAPPKSLS
1810 1820 1830 1840 1850
SPTKSYVSHC SLSIGYGSTA SSEQQQREPS PSATTSSFLS DPATGVIENV
Length:1,850
Mass (Da):199,214
Last modified:June 11, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5345695376E5A527
GO
Isoform aImported (identifier: X5M5N0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     82-83: Missing.
     1341-1343: Missing.
     1735-1850: IPDNEGQHHC...DPATGVIENV → TTKVNTTVIP...PVSSQIPPQA

Show »
Length:1,838
Mass (Da):198,381
Checksum:i533908223E048143
GO
Isoform bImported (identifier: X5M5N0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     82-83: Missing.
     1341-1343: Missing.
     1488-1648: Missing.
     1735-1850: IPDNEGQHHC...DPATGVIENV → TTKVNTTVIP...PVSSQIPPQA

Note: No experimental confirmation available.Curated
Show »
Length:1,677
Mass (Da):181,786
Checksum:i1BA72D2D756C7958
GO
Isoform cImported (identifier: X5M5N0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.
     82-83: Missing.
     1341-1343: Missing.
     1735-1850: IPDNEGQHHC...DPATGVIENV → TTKVNTTVIP...PVSSQIPPQA

Note: No experimental confirmation available.Curated
Show »
Length:1,785
Mass (Da):192,754
Checksum:iC09838A63350A326
GO
Isoform dImported (identifier: X5M5N0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1341-1343: Missing.
     1735-1850: IPDNEGQHHC...DPATGVIENV → TTKVNTTVIP...PVSSQIPPQA

Note: No experimental confirmation available.Curated
Show »
Length:1,840
Mass (Da):198,656
Checksum:i043BA5829D15179A
GO
Isoform eImported (identifier: X5M5N0-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1341-1343: Missing.
     1488-1648: Missing.
     1735-1850: IPDNEGQHHC...DPATGVIENV → TTKVNTTVIP...PVSSQIPPQA

Note: No experimental confirmation available.Curated
Show »
Length:1,679
Mass (Da):182,061
Checksum:iBF64EBE937CEF33A
GO
Isoform fImported (identifier: X5M5N0-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.
     1341-1343: Missing.
     1735-1850: IPDNEGQHHC...DPATGVIENV → TTKVNTTVIP...PVSSQIPPQA

Note: No experimental confirmation available.Curated
Show »
Length:1,787
Mass (Da):193,029
Checksum:i31064623AD911ACE
GO
Isoform gImported (identifier: X5M5N0-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     82-83: Missing.
     1735-1850: IPDNEGQHHC...DPATGVIENV → TTKVNTTVIP...PVSSQIPPQA

Note: No experimental confirmation available.Curated
Show »
Length:1,841
Mass (Da):198,759
Checksum:iCE442AFAA04EC3CD
GO
Isoform hImported (identifier: X5M5N0-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     82-83: Missing.
     1488-1648: Missing.
     1735-1850: IPDNEGQHHC...DPATGVIENV → TTKVNTTVIP...PVSSQIPPQA

Note: No experimental confirmation available.Curated
Show »
Length:1,680
Mass (Da):182,164
Checksum:iF56B10821D821798
GO
Isoform iImported (identifier: X5M5N0-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.
     82-83: Missing.
     1735-1850: IPDNEGQHHC...DPATGVIENV → TTKVNTTVIP...PVSSQIPPQA

Note: No experimental confirmation available.Curated
Show »
Length:1,788
Mass (Da):193,132
Checksum:iBFB11719017E47C0
GO
Isoform jImported (identifier: X5M5N0-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1735-1850: IPDNEGQHHC...DPATGVIENV → TTKVNTTVIP...PVSSQIPPQA

Note: No experimental confirmation available.Curated
Show »
Length:1,843
Mass (Da):199,035
Checksum:iD432299DA2E3636E
GO
Isoform kImported (identifier: X5M5N0-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1488-1648: Missing.
     1735-1850: IPDNEGQHHC...DPATGVIENV → TTKVNTTVIP...PVSSQIPPQA

Note: No experimental confirmation available.Curated
Show »
Length:1,682
Mass (Da):182,439
Checksum:i18DDA946DE44D3DA
GO
Isoform lImported (identifier: X5M5N0-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.
     1735-1850: IPDNEGQHHC...DPATGVIENV → TTKVNTTVIP...PVSSQIPPQA

Note: No experimental confirmation available.Curated
Show »
Length:1,790
Mass (Da):193,407
Checksum:i0AF8A8689F00C25E
GO
Isoform mImported (identifier: X5M5N0-14) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     82-83: Missing.
     1341-1343: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:1,845
Mass (Da):198,560
Checksum:i5C22250BB074F950
GO
Isoform oImported (identifier: X5M5N0-15) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1488-1648: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:1,689
Mass (Da):182,618
Checksum:iD80DC949DC00562B
GO
Isoform pImported (identifier: X5M5N0-16) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1341-1343: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:1,847
Mass (Da):198,835
Checksum:i5FA63BE77A02FA37
GO
Isoform qImported (identifier: X5M5N0-17) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1341-1343: Missing.
     1488-1648: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:1,686
Mass (Da):182,240
Checksum:i21524E573AD6D48C
GO
Isoform rImported (identifier: X5M5N0-18) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     82-83: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:1,848
Mass (Da):198,938
Checksum:i17E7E740F2FB49ED
GO
Isoform sImported (identifier: X5M5N0-19) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     82-83: Missing.
     1488-1648: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:1,687
Mass (Da):182,343
Checksum:i28544B3FBD12F9A6
GO
Isoform tImported (identifier: X5M5N0-20) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     82-83: Missing.
     1341-1343: Missing.
     1488-1648: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:1,684
Mass (Da):181,965
Checksum:i97335CF8B7606D48
GO
Isoform uImported (identifier: X5M5N0-21) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1650: Missing.
     1735-1850: IPDNEGQHHC...DPATGVIENV → TTKVNTTVIP...PVSSQIPPQA

Note: No experimental confirmation available.Curated
Show »
Length:193
Mass (Da):21,367
Checksum:i36CE2CE7BF614BF7
GO
Isoform vImported (identifier: X5M5N0-22) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1650: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:200
Mass (Da):21,546
Checksum:iC10256A25DBEEAF5
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0576831 – 1650Missing in isoform u and isoform v. CuratedAdd BLAST1650
Alternative sequenceiVSP_0576841 – 53Missing in isoform c, isoform f, isoform i and isoform l. CuratedAdd BLAST53
Alternative sequenceiVSP_05768582 – 83Missing in isoform a, isoform b, isoform c, isoform g, isoform h, isoform i, isoform m, isoform r, isoform s and isoform t. Curated2
Alternative sequenceiVSP_0576861341 – 1343Missing in isoform a, isoform b, isoform c, isoform d, isoform e, isoform f, isoform m, isoform p, isoform q and isoform t. Curated3
Alternative sequenceiVSP_0576871488 – 1648Missing in isoform b, isoform e, isoform h, isoform k, isoform o, isoform q, isoform s and isoform t. CuratedAdd BLAST161
Alternative sequenceiVSP_0576881735 – 1850IPDNE…VIENV → TTKVNTTVIPSDVLATRMTM SQSSTKSSNVSVSSRHRDNQ SAPPRHHHHQPHPPHHPHLQ NHYHPPQNHTSATAPCPSAM VQLQAVSNNNVNPLHQPPHP VSSQIPPQA in isoform a, isoform b, isoform c, isoform d, isoform e, isoform f, isoform g, isoform h, isoform i, isoform j, isoform k, isoform l and isoform u. CuratedAdd BLAST116

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CAA92591.3
BX284604 Genomic DNA Translation: CAD59142.2
BX284604 Genomic DNA Translation: CCE71523.1
BX284604 Genomic DNA Translation: CCE71524.1
BX284604 Genomic DNA Translation: CCE71525.1
BX284604 Genomic DNA Translation: CCE71526.1
BX284604 Genomic DNA Translation: CCE71527.1
BX284604 Genomic DNA Translation: CCE71529.1
BX284604 Genomic DNA Translation: CCE71530.1
BX284604 Genomic DNA Translation: CCE71531.1
BX284604 Genomic DNA Translation: CCE71532.1
BX284604 Genomic DNA Translation: CCE71533.1
BX284604 Genomic DNA Translation: CCE71534.1
BX284604 Genomic DNA Translation: CDO41073.1
BX284604 Genomic DNA Translation: CDO41074.1
BX284604 Genomic DNA Translation: CDO41075.1
BX284604 Genomic DNA Translation: CDO41076.1
BX284604 Genomic DNA Translation: CDO41077.1
BX284604 Genomic DNA Translation: CDO41078.1
BX284604 Genomic DNA Translation: CDO41079.1
BX284604 Genomic DNA Translation: CDO41080.1
BX284604 Genomic DNA Translation: CDO41081.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T19964

NCBI Reference Sequences

More...
RefSeqi
NP_001255367.1, NM_001268438.1 [X5M5N0-14]
NP_001255368.1, NM_001268439.1 [X5M5N0-11]
NP_001255369.1, NM_001268440.1 [X5M5N0-12]
NP_001255370.1, NM_001268441.1 [X5M5N0-5]
NP_001255371.1, NM_001268442.1 [X5M5N0-6]
NP_001255372.1, NM_001268443.1 [X5M5N0-8]
NP_001255373.1, NM_001268444.1 [X5M5N0-9]
NP_001255374.1, NM_001268445.1 [X5M5N0-13]
NP_001255375.1, NM_001268446.1 [X5M5N0-7]
NP_001255376.1, NM_001268447.1 [X5M5N0-10]
NP_001255377.1, NM_001268448.1 [X5M5N0-4]
NP_001294032.1, NM_001307103.1 [X5M5N0-1]
NP_001294033.1, NM_001307104.1 [X5M5N0-15]
NP_001294034.1, NM_001307105.1 [X5M5N0-16]
NP_001294035.1, NM_001307106.1 [X5M5N0-17]
NP_001294036.1, NM_001307107.1 [X5M5N0-18]
NP_001294037.1, NM_001307108.1 [X5M5N0-19]
NP_001294038.1, NM_001307109.1 [X5M5N0-20]
NP_001294039.1, NM_001307110.1 [X5M5N0-21]
NP_001294040.1, NM_001307111.1 [X5M5N0-22]
NP_501603.3, NM_069202.5 [X5M5N0-2]
NP_872075.2, NM_182275.4 [X5M5N0-3]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C46C2.1a; C46C2.1a; WBGene00006941 [X5M5N0-2]
C46C2.1b; C46C2.1b; WBGene00006941 [X5M5N0-3]
C46C2.1c; C46C2.1c; WBGene00006941 [X5M5N0-4]
C46C2.1d.1; C46C2.1d.1; WBGene00006941 [X5M5N0-5]
C46C2.1d.2; C46C2.1d.2; WBGene00006941 [X5M5N0-5]
C46C2.1e.1; C46C2.1e.1; WBGene00006941 [X5M5N0-6]
C46C2.1e.2; C46C2.1e.2; WBGene00006941 [X5M5N0-6]
C46C2.1f; C46C2.1f; WBGene00006941 [X5M5N0-7]
C46C2.1g; C46C2.1g; WBGene00006941 [X5M5N0-8]
C46C2.1h; C46C2.1h; WBGene00006941 [X5M5N0-9]
C46C2.1i; C46C2.1i; WBGene00006941 [X5M5N0-10]
C46C2.1j.1; C46C2.1j.1; WBGene00006941 [X5M5N0-11]
C46C2.1j.2; C46C2.1j.2; WBGene00006941 [X5M5N0-11]
C46C2.1k.1; C46C2.1k.1; WBGene00006941 [X5M5N0-12]
C46C2.1k.2; C46C2.1k.2; WBGene00006941 [X5M5N0-12]
C46C2.1l; C46C2.1l; WBGene00006941 [X5M5N0-13]
C46C2.1m; C46C2.1m; WBGene00006941 [X5M5N0-14]
C46C2.1n.1; C46C2.1n.1; WBGene00006941 [X5M5N0-1]
C46C2.1n.2; C46C2.1n.2; WBGene00006941 [X5M5N0-1]
C46C2.1o.1; C46C2.1o.1; WBGene00006941 [X5M5N0-15]
C46C2.1o.2; C46C2.1o.2; WBGene00006941 [X5M5N0-15]
C46C2.1p.1; C46C2.1p.1; WBGene00006941 [X5M5N0-16]
C46C2.1p.2; C46C2.1p.2; WBGene00006941 [X5M5N0-16]
C46C2.1q.1; C46C2.1q.1; WBGene00006941 [X5M5N0-17]
C46C2.1q.2; C46C2.1q.2; WBGene00006941 [X5M5N0-17]
C46C2.1r; C46C2.1r; WBGene00006941 [X5M5N0-18]
C46C2.1s; C46C2.1s; WBGene00006941 [X5M5N0-19]
C46C2.1t; C46C2.1t; WBGene00006941 [X5M5N0-20]
C46C2.1u; C46C2.1u; WBGene00006941 [X5M5N0-21]
C46C2.1v; C46C2.1v; WBGene00006941 [X5M5N0-22]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
177743

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_C46C2.1

UCSC genome browser

More...
UCSCi
C46C2.1a c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CAA92591.3
BX284604 Genomic DNA Translation: CAD59142.2
BX284604 Genomic DNA Translation: CCE71523.1
BX284604 Genomic DNA Translation: CCE71524.1
BX284604 Genomic DNA Translation: CCE71525.1
BX284604 Genomic DNA Translation: CCE71526.1
BX284604 Genomic DNA Translation: CCE71527.1
BX284604 Genomic DNA Translation: CCE71529.1
BX284604 Genomic DNA Translation: CCE71530.1
BX284604 Genomic DNA Translation: CCE71531.1
BX284604 Genomic DNA Translation: CCE71532.1
BX284604 Genomic DNA Translation: CCE71533.1
BX284604 Genomic DNA Translation: CCE71534.1
BX284604 Genomic DNA Translation: CDO41073.1
BX284604 Genomic DNA Translation: CDO41074.1
BX284604 Genomic DNA Translation: CDO41075.1
BX284604 Genomic DNA Translation: CDO41076.1
BX284604 Genomic DNA Translation: CDO41077.1
BX284604 Genomic DNA Translation: CDO41078.1
BX284604 Genomic DNA Translation: CDO41079.1
BX284604 Genomic DNA Translation: CDO41080.1
BX284604 Genomic DNA Translation: CDO41081.1
PIRiT19964
RefSeqiNP_001255367.1, NM_001268438.1 [X5M5N0-14]
NP_001255368.1, NM_001268439.1 [X5M5N0-11]
NP_001255369.1, NM_001268440.1 [X5M5N0-12]
NP_001255370.1, NM_001268441.1 [X5M5N0-5]
NP_001255371.1, NM_001268442.1 [X5M5N0-6]
NP_001255372.1, NM_001268443.1 [X5M5N0-8]
NP_001255373.1, NM_001268444.1 [X5M5N0-9]
NP_001255374.1, NM_001268445.1 [X5M5N0-13]
NP_001255375.1, NM_001268446.1 [X5M5N0-7]
NP_001255376.1, NM_001268447.1 [X5M5N0-10]
NP_001255377.1, NM_001268448.1 [X5M5N0-4]
NP_001294032.1, NM_001307103.1 [X5M5N0-1]
NP_001294033.1, NM_001307104.1 [X5M5N0-15]
NP_001294034.1, NM_001307105.1 [X5M5N0-16]
NP_001294035.1, NM_001307106.1 [X5M5N0-17]
NP_001294036.1, NM_001307107.1 [X5M5N0-18]
NP_001294037.1, NM_001307108.1 [X5M5N0-19]
NP_001294038.1, NM_001307109.1 [X5M5N0-20]
NP_001294039.1, NM_001307110.1 [X5M5N0-21]
NP_001294040.1, NM_001307111.1 [X5M5N0-22]
NP_501603.3, NM_069202.5 [X5M5N0-2]
NP_872075.2, NM_182275.4 [X5M5N0-3]

3D structure databases

SMRiX5M5N0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiX5M5N0, 2 interactors
MINTiX5M5N0
STRINGi6239.C46C2.1m

Proteomic databases

PaxDbiX5M5N0
PeptideAtlasiX5M5N0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC46C2.1a; C46C2.1a; WBGene00006941 [X5M5N0-2]
C46C2.1b; C46C2.1b; WBGene00006941 [X5M5N0-3]
C46C2.1c; C46C2.1c; WBGene00006941 [X5M5N0-4]
C46C2.1d.1; C46C2.1d.1; WBGene00006941 [X5M5N0-5]
C46C2.1d.2; C46C2.1d.2; WBGene00006941 [X5M5N0-5]
C46C2.1e.1; C46C2.1e.1; WBGene00006941 [X5M5N0-6]
C46C2.1e.2; C46C2.1e.2; WBGene00006941 [X5M5N0-6]
C46C2.1f; C46C2.1f; WBGene00006941 [X5M5N0-7]
C46C2.1g; C46C2.1g; WBGene00006941 [X5M5N0-8]
C46C2.1h; C46C2.1h; WBGene00006941 [X5M5N0-9]
C46C2.1i; C46C2.1i; WBGene00006941 [X5M5N0-10]
C46C2.1j.1; C46C2.1j.1; WBGene00006941 [X5M5N0-11]
C46C2.1j.2; C46C2.1j.2; WBGene00006941 [X5M5N0-11]
C46C2.1k.1; C46C2.1k.1; WBGene00006941 [X5M5N0-12]
C46C2.1k.2; C46C2.1k.2; WBGene00006941 [X5M5N0-12]
C46C2.1l; C46C2.1l; WBGene00006941 [X5M5N0-13]
C46C2.1m; C46C2.1m; WBGene00006941 [X5M5N0-14]
C46C2.1n.1; C46C2.1n.1; WBGene00006941 [X5M5N0-1]
C46C2.1n.2; C46C2.1n.2; WBGene00006941 [X5M5N0-1]
C46C2.1o.1; C46C2.1o.1; WBGene00006941 [X5M5N0-15]
C46C2.1o.2; C46C2.1o.2; WBGene00006941 [X5M5N0-15]
C46C2.1p.1; C46C2.1p.1; WBGene00006941 [X5M5N0-16]
C46C2.1p.2; C46C2.1p.2; WBGene00006941 [X5M5N0-16]
C46C2.1q.1; C46C2.1q.1; WBGene00006941 [X5M5N0-17]
C46C2.1q.2; C46C2.1q.2; WBGene00006941 [X5M5N0-17]
C46C2.1r; C46C2.1r; WBGene00006941 [X5M5N0-18]
C46C2.1s; C46C2.1s; WBGene00006941 [X5M5N0-19]
C46C2.1t; C46C2.1t; WBGene00006941 [X5M5N0-20]
C46C2.1u; C46C2.1u; WBGene00006941 [X5M5N0-21]
C46C2.1v; C46C2.1v; WBGene00006941 [X5M5N0-22]
GeneIDi177743
KEGGicel:CELE_C46C2.1
UCSCiC46C2.1a c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
177743
WormBaseiC46C2.1a ; CE37331 ; WBGene00006941 ; wnk-1
C46C2.1b ; CE37332 ; WBGene00006941 ; wnk-1
C46C2.1c ; CE46706 ; WBGene00006941 ; wnk-1
C46C2.1d ; CE46603 ; WBGene00006941 ; wnk-1
C46C2.1e ; CE46553 ; WBGene00006941 ; wnk-1
C46C2.1f ; CE46627 ; WBGene00006941 ; wnk-1
C46C2.1g ; CE46722 ; WBGene00006941 ; wnk-1
C46C2.1h ; CE46797 ; WBGene00006941 ; wnk-1
C46C2.1i ; CE46749 ; WBGene00006941 ; wnk-1
C46C2.1j ; CE46831 ; WBGene00006941 ; wnk-1
C46C2.1k ; CE46763 ; WBGene00006941 ; wnk-1
C46C2.1l ; CE46557 ; WBGene00006941 ; wnk-1
C46C2.1m ; CE46636 ; WBGene00006941 ; wnk-1
C46C2.1n ; CE49690 ; WBGene00006941 ; wnk-1
C46C2.1o ; CE49733 ; WBGene00006941 ; wnk-1
C46C2.1p ; CE49626 ; WBGene00006941 ; wnk-1
C46C2.1q ; CE49684 ; WBGene00006941 ; wnk-1
C46C2.1r ; CE49717 ; WBGene00006941 ; wnk-1
C46C2.1s ; CE49622 ; WBGene00006941 ; wnk-1
C46C2.1t ; CE49653 ; WBGene00006941 ; wnk-1
C46C2.1u ; CE49693 ; WBGene00006941 ; wnk-1
C46C2.1v ; CE49732 ; WBGene00006941 ; wnk-1

Phylogenomic databases

eggNOGiKOG0584 Eukaryota
ENOG410XQWZ LUCA
GeneTreeiENSGT00940000171556
HOGENOMiHOG000022086
KOiK08867
OMAiMDQECAQ
OrthoDBi695382at2759

Enzyme and pathway databases

ReactomeiR-CEL-2672351 Stimuli-sensing channels

Miscellaneous databases

Protein Ontology

More...
PROi
PR:X5M5N0

Gene expression databases

BgeeiWBGene00006941 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR024678 Kinase_OSR1/WNK_CCT
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF12202 OSR1_C, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWNK_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: X5M5N0
Secondary accession number(s): H2L282
, H2L283, H2L284, H2L285, H2L286, H2L288, H2L289, H2L290, H2L291, H2L292, H2L293, Q18657, Q8I127, X5LPT1, X5LPT5, X5LV40, X5LV44, X5LX64, X5M5N6, X5M8T1, X5M8T5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 24, 2015
Last sequence update: June 11, 2014
Last modified: May 8, 2019
This is version 38 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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