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Entry version 38 (08 May 2019)
Sequence version 1 (11 Jun 2014)
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Protein

Exocyst complex component SEC10a

Gene

SEC10a

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane during regulated or polarized secretion. Involved in polarized cell growth and organ morphogenesis. During cytokinesis, involved in cell plate initiation, cell plate maturation and formation of new primary cell wall.2 Publications

Caution

This locus, comprising the single gene At5g12370 in the original reference genome assembly, contains in fact two paralogous genes in tandem, SEC10a (At5g12370) and SEC10b (At5g12365), and a sequence segment of 7 kb in length is missing from the reference genome sequence.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processExocytosis, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Exocyst complex component SEC10a1 Publication
Short name:
AtSec10a1 Publication
Alternative name(s):
Exocyst complex component 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SEC10a1 Publication
Ordered Locus Names:At5g12370Imported
ORF Names:T2L20.2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT5G12370

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

No visible phenotype, due to the redundancy with SEC10b.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001189481 – 825Exocyst complex component SEC10aAdd BLAST825

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
X5JA13

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
X5JA13

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in seedlings, roots, leaves and flowers.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
X5JA13 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The exocyst complex is composed of SEC3, SEC5, SEC6, SEC8, SEC10, EXO70A1 and EXO84B. Interacts with EXO84B. Binds to EXO70E2 (PubMed:24307681).2 Publications

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT5G12370.2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
X5JA13

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili244 – 266Sequence analysisAdd BLAST23

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SEC10 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3745 Eukaryota
ENOG410XSQQ LUCA

KEGG Orthology (KO)

More...
KOi
K19984

Identification of Orthologs from Complete Genome Data

More...
OMAi
AMCAICD

Database of Orthologous Groups

More...
OrthoDBi
225235at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
X5JA13

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033960 EXOC5/Sec10
IPR009976 Sec10-like

The PANTHER Classification System

More...
PANTHERi
PTHR12100 PTHR12100, 1 hit
PTHR12100:SF0 PTHR12100:SF0, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07393 Sec10, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 1 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoform i produced by alternative splicing. AlignAdd to basket
Note: A number of isoforms are produced. According to EST sequences.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: X5JA13-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTEGIRARGP RSSSVNSVPL ILDIEDFKGD FSFDALFGNL VNDLLPSFLD
60 70 80 90 100
EEADSGDGHG NIAGVDGLTN GHLRGQSAPL SSAPFFPEVD GLLSLFKDAC
110 120 130 140 150
KELVDLRKQV DGRLNTLKKE VSTQDSKHRK TLTEIEKGVD GLFESFARLD
160 170 180 190 200
GRISSVGQTA AKIGDHLQSA DAQRETASQT IDLIKYLMEF NGSPGDLMEL
210 220 230 240 250
SALFSDDSRV AEAASIAQKL RSFAEEDIGR QGASAAAGNA TPGRGLEVAV
260 270 280 290 300
ANLQDYCNEL ENRLLSRFDA ASQRRDLSTM SECAKILSQF NRGTSAMQHY
310 320 330 340 350
VATRPMFIDV EVMNSDIRLV LGDHGSQPSP SNVARGLSAL FKEITDTVRK
360 370 380 390 400
EAATITAVFP TPNEVMAILV QRVLEQRVTG ILDKILAKPS LMSPPPVQEG
410 420 430 440 450
GLLLYLRMLA VAYERTQELA KDLRAVGCGD LDVEDLTESL FSSHKDEYPE
460 470 480 490 500
HERASLKQLY QAKMEELRAE SQQVSESSGT IGRSKGASIS SSLQQISVTV
510 520 530 540 550
VTDFVRWNEE AITRCTLFSS QPATLAANVK AIFTCLLDQV SVYITEGLER
560 570 580 590 600
ARDSLSEAAA LRERFVLGRR VAAAAASAAE AAAAAGESSF KSFMVAVQRC
610 620 630 640 650
GSSVAIVQQY FANSISRLLL PVDGAHAASC EEMSTALSKA EAAAYKGLQQ
660 670 680 690 700
CIETVMAEVD RLLSSEQKST DYRSTDDGIA SDHRPTNACI RVVAYLSRVL
710 720 730 740 750
ESAFTALEGL NKQAFLTELG NRLEKLLLTH WQKFTFNPSG GLRLKRDLNE
760 770 780 790 800
YVGFVKSFGA PSVDEKFELL GIIANVFIVA PDSLPTLFEG SPSIRKDAQR
810 820
FIQLREDYKS AKLATKLSSL WPSLS
Length:825
Mass (Da):89,694
Last modified:June 11, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0D02882FC81501EB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F4K0X7F4K0X7_ARATH
Exocyst complex component sec10
SEC10 At5g12370
820Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAC42898 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
HG764169 Genomic DNA Translation: CDJ79776.1
AL592312 Genomic DNA Translation: CAC42898.1 Sequence problems.
CP002688 Genomic DNA Translation: AED91800.1
CP002688 Genomic DNA Translation: AED91801.1
AK222187 mRNA Translation: BAD95324.1

NCBI Reference Sequences

More...
RefSeqi
NP_001031871.1, NM_001036794.2 [X5JA13-1]
NP_568270.3, NM_121275.4 [X5JA13-1]

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT5G12370.1; AT5G12370.1; AT5G12370 [X5JA13-1]
AT5G12370.2; AT5G12370.2; AT5G12370 [X5JA13-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
831112

Gramene; a comparative resource for plants

More...
Gramenei
AT5G12370.1; AT5G12370.1; AT5G12370 [X5JA13-1]
AT5G12370.2; AT5G12370.2; AT5G12370 [X5JA13-1]

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT5G12370

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HG764169 Genomic DNA Translation: CDJ79776.1
AL592312 Genomic DNA Translation: CAC42898.1 Sequence problems.
CP002688 Genomic DNA Translation: AED91800.1
CP002688 Genomic DNA Translation: AED91801.1
AK222187 mRNA Translation: BAD95324.1
RefSeqiNP_001031871.1, NM_001036794.2 [X5JA13-1]
NP_568270.3, NM_121275.4 [X5JA13-1]

3D structure databases

SMRiX5JA13
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT5G12370.2

PTM databases

iPTMnetiX5JA13

Proteomic databases

PRIDEiX5JA13

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G12370.1; AT5G12370.1; AT5G12370 [X5JA13-1]
AT5G12370.2; AT5G12370.2; AT5G12370 [X5JA13-1]
GeneIDi831112
GrameneiAT5G12370.1; AT5G12370.1; AT5G12370 [X5JA13-1]
AT5G12370.2; AT5G12370.2; AT5G12370 [X5JA13-1]
KEGGiath:AT5G12370

Organism-specific databases

AraportiAT5G12370

Phylogenomic databases

eggNOGiKOG3745 Eukaryota
ENOG410XSQQ LUCA
KOiK19984
OMAiAMCAICD
OrthoDBi225235at2759
PhylomeDBiX5JA13

Miscellaneous databases

Protein Ontology

More...
PROi
PR:X5JA13

Gene expression databases

ExpressionAtlasiX5JA13 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR033960 EXOC5/Sec10
IPR009976 Sec10-like
PANTHERiPTHR12100 PTHR12100, 1 hit
PTHR12100:SF0 PTHR12100:SF0, 1 hit
PfamiView protein in Pfam
PF07393 Sec10, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSECAA_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: X5JA13
Secondary accession number(s): Q56W60, Q8RVQ5, Q94CK5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 18, 2017
Last sequence update: June 11, 2014
Last modified: May 8, 2019
This is version 38 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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