UniProtKB - X5DNX5 (X5DNX5_HUMAN)
Protein
Phosphodiesterase
Gene
PDE4B
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:3.1.4.53ARBA annotation
Cofactori
a divalent metal cationUniRule annotationNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.UniRule annotation
: 3',5'-cyclic AMP degradation Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes AMP from 3',5'-cyclic AMP.ARBA annotationProteins known to be involved in this subpathway in this organism are:
- Phosphodiesterase, Phosphodiesterase (PDE4C), Phosphodiesterase (PDE4C), 3',5'-cyclic-AMP phosphodiesterase (PDE4B), Phosphodiesterase (PDE4D), Phosphodiesterase (PDE8A), Phosphodiesterase, Phosphodiesterase (PDE4B), Phosphodiesterase (PDE4C), Phosphodiesterase, Phosphodiesterase, 3',5'-cyclic-AMP phosphodiesterase (PDE4B), 3',5'-cyclic-AMP phosphodiesterase (PDE4D), Phosphodiesterase (PDE8B), 3',5'-cyclic-AMP phosphodiesterase (PDE4B), Phosphodiesterase (PDE4D), 3',5'-cyclic-AMP phosphodiesterase (PDE4DN2), Phosphodiesterase, cAMP-specific 3',5'-cyclic phosphodiesterase 4C (PDE4C), cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A), 3',5'-cyclic-AMP phosphodiesterase (HSPDE4D), Phosphodiesterase, Phosphodiesterase (PDE4C), Phosphodiesterase (PDE4D), Phosphodiesterase (PDE4C), High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (PDE7A), cAMP-specific 3',5'-cyclic phosphodiesterase 7B (PDE7B), cAMP-specific 3',5'-cyclic phosphodiesterase 4D (PDE4D), cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B), Phosphodiesterase (PDE4C), Phosphodiesterase (PDE4D), High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (PDE8A), High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (PDE8B), 3',5'-cyclic-AMP phosphodiesterase (PDE4A), 3',5'-cyclic-AMP phosphodiesterase (PDE4B), Phosphodiesterase (PDE4B), 3',5'-cyclic-AMP phosphodiesterase (PDE4C), 3',5'-cyclic-AMP phosphodiesterase (PDE4A), Phosphodiesterase (PDE4C), cAMP-specific 3',5'-cyclic phosphodiesterase 4A (PDE4A), 3',5'-cyclic-AMP phosphodiesterase (PDE4B), Phosphodiesterase, 3',5'-cyclic-AMP phosphodiesterase (PDE4C)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from 3',5'-cyclic AMP, the pathway 3',5'-cyclic AMP degradation and in Purine metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 406 | Proton donorUniRule annotation | 1 | |
Metal bindingi | 410 | Divalent metal cation 1UniRule annotation | 1 | |
Metal bindingi | 446 | Divalent metal cation 1UniRule annotation | 1 | |
Metal bindingi | 447 | Divalent metal cation 1UniRule annotation | 1 | |
Metal bindingi | 447 | Divalent metal cation 2UniRule annotation | 1 | |
Binding sitei | 447 | cNMPUniRule annotation | 1 | |
Metal bindingi | 564 | Divalent metal cation 1UniRule annotation | 1 | |
Binding sitei | 564 | cNMPUniRule annotation | 1 | |
Binding sitei | 615 | cNMPUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 406 – 410 | cNMPUniRule annotation | 5 |
GO - Molecular functioni
- 3',5'-cyclic-AMP phosphodiesterase activity Source: InterPro
- gamma-tubulin binding Source: Ensembl
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- cAMP catabolic process Source: UniProtKB-UniPathway
- cellular response to drug Source: Ensembl
- cellular response to lipopolysaccharide Source: Ensembl
- neutrophil chemotaxis Source: Ensembl
- neutrophil homeostasis Source: Ensembl
- signal transduction Source: InterPro
Keywordsi
Molecular function | HydrolaseUniRule annotationARBA annotation |
Ligand | cAMPARBA annotation, Metal-bindingUniRule annotationARBA annotation |
Enzyme and pathway databases
UniPathwayi | UPA00762;UER00747 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:PDE4BImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000184588.17 |
Subcellular locationi
Cytoskeleton
- centrosome Source: Ensembl
- gamma-tubulin complex Source: Ensembl
Cytosol
- cytosol Source: Ensembl
Other locations
- cell periphery Source: Ensembl
- dendritic spine Source: Ensembl
- excitatory synapse Source: Ensembl
- membrane Source: Ensembl
- postsynaptic density Source: Ensembl
- synaptic vesicle Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSG00000184588, Expressed in corpus callosum and 241 other tissues |
ExpressionAtlasi | X5DNX5, baseline and differential |
Interactioni
GO - Molecular functioni
- gamma-tubulin binding Source: Ensembl
Chemistry databases
BindingDBi | X5DNX5 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 330 – 659 | PDEaseInterPro annotationAdd BLAST | 330 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 51 – 78 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 189 – 209 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 282 – 301 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 685 – 736 | DisorderedSequence analysisAdd BLAST | 52 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 716 – 736 | PolyampholyteSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the cyclic nucleotide phosphodiesterase family.UniRule annotation
Phylogenomic databases
HOGENOMi | CLU_005940_5_3_1 |
OrthoDBi | 904682at2759 |
PhylomeDBi | X5DNX5 |
Family and domain databases
CDDi | cd00077, HDc, 1 hit |
Gene3Di | 1.10.1300.10, 1 hit |
InterProi | View protein in InterPro IPR003607, HD/PDEase_dom IPR043371, PDE4 IPR040844, PDE4_UCR IPR023088, PDEase IPR002073, PDEase_catalytic_dom IPR036971, PDEase_catalytic_dom_sf IPR023174, PDEase_CS |
PANTHERi | PTHR11347:SF108, PTHR11347:SF108, 1 hit |
Pfami | View protein in Pfam PF18100, PDE4_UCR, 1 hit PF00233, PDEase_I, 1 hit |
PRINTSi | PR00387, PDIESTERASE1 |
SMARTi | View protein in SMART SM00471, HDc, 1 hit |
PROSITEi | View protein in PROSITE PS00126, PDEASE_I_1, 1 hit PS51845, PDEASE_I_2, 1 hit |
i Sequence
Sequence statusi: Fragment.
X5DNX5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKKSRSVMTV MADDNVKDYF ECSLSKSYSS SSNTLGIDLW RGRRCCSGNL
60 70 80 90 100
QLPPLSQRQS ERARTPEGDG ISRPTTLPLT TLPSIAITTV SQECFDVENG
110 120 130 140 150
PSPGRSPLDP QASSSAGLVL HATFPGHSQR RESFLYRSDS DYDLSPKAMS
160 170 180 190 200
RNSSLPSEQH GDDLIVTPFA QVLASLRSVR NNFTILTNLH GTSNKRSPAA
210 220 230 240 250
SQPPVSRVNP QEESYQKLAM ETLEELDWCL DQLETIQTYR SVSEMASNKF
260 270 280 290 300
KRMLNRELTH LSEMSRSGNQ VSEYISNTFL DKQNDVEIPS PTQKDREKKK
310 320 330 340 350
KQQLMTQISG VKKLMHSSSL NNTSISRFGV NTENEDHLAK ELEDLNKWGL
360 370 380 390 400
NIFNVAGYSH NRPLTCIMYA IFQERDLLKT FRISSDTFIT YMMTLEDHYH
410 420 430 440 450
SDVAYHNSLH AADVAQSTHV LLSTPALDAV FTDLEILAAI FAAAIHDVDH
460 470 480 490 500
PGVSNQFLIN TNSELALMYN DESVLENHHL AVGFKLLQEE HCDIFMNLTK
510 520 530 540 550
KQRQTLRKMV IDMVLATDMS KHMSLLADLK TMVETKKVTS SGVLLLDNYT
560 570 580 590 600
DRIQVLRNMV HCADLSNPTK SLELYRQWTD RIMEEFFQQG DKERERGMEI
610 620 630 640 650
SPMCDKHTAS VEKSQVGFID YIVHPLWETW ADLVQPDAQD ILDTLEDNRN
660 670 680 690 700
WYQSMIPQSP SPPLDEQNRD CQGLMEKFQF ELTLDEEDSE GPEKEGEGHS
710 720 730
YFSSTKTLCV IDPENRDSLG ETDIDIATED KSPVDT
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 736 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KJ534916 mRNA Translation: AHW56556.1 |
RefSeqi | NP_001032418.1, NM_001037341.1 NP_002591.2, NM_002600.3 |
Genome annotation databases
GeneIDi | 5142 |
KEGGi | hsa:5142 |
UCSCi | uc001dcn.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KJ534916 mRNA Translation: AHW56556.1 |
RefSeqi | NP_001032418.1, NM_001037341.1 NP_002591.2, NM_002600.3 |
3D structure databases
SMRi | X5DNX5 |
ModBasei | Search... |
Chemistry databases
BindingDBi | X5DNX5 |
Proteomic databases
MaxQBi | X5DNX5 |
Protocols and materials databases
Antibodypediai | 1172, 470 antibodies |
Genome annotation databases
GeneIDi | 5142 |
KEGGi | hsa:5142 |
UCSCi | uc001dcn.4, human |
Organism-specific databases
CTDi | 5142 |
EuPathDBi | HostDB:ENSG00000184588.17 |
Phylogenomic databases
HOGENOMi | CLU_005940_5_3_1 |
OrthoDBi | 904682at2759 |
PhylomeDBi | X5DNX5 |
Enzyme and pathway databases
UniPathwayi | UPA00762;UER00747 |
Miscellaneous databases
BioGRID-ORCSi | 5142, 1 hit in 847 CRISPR screens |
ChiTaRSi | PDE4B, human |
GenomeRNAii | 5142 |
Gene expression databases
Bgeei | ENSG00000184588, Expressed in corpus callosum and 241 other tissues |
ExpressionAtlasi | X5DNX5, baseline and differential |
Family and domain databases
CDDi | cd00077, HDc, 1 hit |
Gene3Di | 1.10.1300.10, 1 hit |
InterProi | View protein in InterPro IPR003607, HD/PDEase_dom IPR043371, PDE4 IPR040844, PDE4_UCR IPR023088, PDEase IPR002073, PDEase_catalytic_dom IPR036971, PDEase_catalytic_dom_sf IPR023174, PDEase_CS |
PANTHERi | PTHR11347:SF108, PTHR11347:SF108, 1 hit |
Pfami | View protein in Pfam PF18100, PDE4_UCR, 1 hit PF00233, PDEase_I, 1 hit |
PRINTSi | PR00387, PDIESTERASE1 |
SMARTi | View protein in SMART SM00471, HDc, 1 hit |
PROSITEi | View protein in PROSITE PS00126, PDEASE_I_1, 1 hit PS51845, PDEASE_I_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | X5DNX5_HUMAN | |
Accessioni | X5DNX5Primary (citable) accession number: X5DNX5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 11, 2014 |
Last sequence update: | June 11, 2014 | |
Last modified: | December 2, 2020 | |
This is version 44 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |