Adenosine receptor A2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• alpha-actinin binding Source: Ensembl
• G protein-coupled adenosine receptor activity Source: UniProtKB-UniRule
• protein-containing complex binding Source: Ensembl
• type 5 metabotropic glutamate receptor binding Source: Ensembl

GO - Biological processⁱ

• adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: Ensembl
• astrocyte activation Source: Ensembl
• eating behavior Source: Ensembl
• excitatory postsynaptic potential Source: Ensembl
• inhibitory postsynaptic potential Source: Ensembl
• locomotory behavior Source: Ensembl
• membrane depolarization Source: Ensembl
• negative regulation of alpha-beta T cell activation Source: Ensembl
• negative regulation of cell population proliferation Source: Ensembl
• negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
• negative regulation of inflammatory response Source: Ensembl
• negative regulation of locomotion Source: Ensembl
• negative regulation of neuron apoptotic process Source: Ensembl
• negative regulation of protein kinase activity Source: Ensembl
• negative regulation of vascular permeability Source: Ensembl
• neuron projection morphogenesis Source: Ensembl
• positive regulation of acetylcholine secretion, neurotransmission Source: Ensembl
• positive regulation of apoptotic signaling pathway Source: Ensembl
• positive regulation of circadian sleep/wake cycle, sleep Source: Ensembl
• positive regulation of glutamate secretion Source: Ensembl
• positive regulation of long-term synaptic potentiation Source: Ensembl
• positive regulation of protein secretion Source: Ensembl
• positive regulation of renal sodium excretion Source: Ensembl
• positive regulation of synaptic transmission, GABAergic Source: Ensembl
• positive regulation of synaptic transmission, glutamatergic Source: Ensembl
• positive regulation of urine volume Source: Ensembl
• prepulse inhibition Source: Ensembl
• protein kinase C-activating G protein-coupled receptor signaling pathway Source: Ensembl
• regulation of calcium ion transport Source: Ensembl
• regulation of mitochondrial membrane potential Source: Ensembl
• regulation of norepinephrine secretion Source: Ensembl
• regulation of synaptic vesicle exocytosis Source: Ensembl
• regulation of transcription, DNA-templated Source: Ensembl
• response to amphetamine Source: Ensembl
• response to caffeine Source: Ensembl
• response to xenobiotic stimulus Source: Ensembl
• synaptic transmission, cholinergic Source: Ensembl
• synaptic transmission, dopaminergic Source: Ensembl
• synaptic transmission, glutamatergic Source: Ensembl
• vasodilation Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Keywords - PTMⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• alpha-actinin binding Source: Ensembl
• type 5 metabotropic glutamate receptor binding Source: Ensembl

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Fragment.

        10         20         30         40         50
MPIMGSSVYI TVELAIAVLA ILGNVLVCWA VWLNSNLQNV TNYFVVSLAA 
        60         70         80         90        100
ADIAVGVLAI PFAITISTGF CAACHGCLFI ACFVLVLTQS SIFSLLAIAI 
       110        120        130        140        150
DRYIAIRIPL RYNGLVTGTR AKGIIAICWV LSFAIGLTPM LGWNNCGQPK 
       160        170        180        190        200
EGKNHSQGCG EGQVACLFED VVPMNYMVYF NFFACVLVPL LLMLGVYLRI 
       210        220        230        240        250
FLAARRQLKQ MESQPLPGER ARSTLQKEVH AAKSLAIIVG LFALCWLPLH 
       260        270        280        290        300
IINCFTFFCP DCSHAPLWLM YLAIVLSHTN SVVNPFIYAY RIREFRQTFR 
       310        320        330        340        350
KIIRSHVLRQ QEPFKAAGTS ARVLAAHGSD GEQVSLRLNG HPPGVWANGS 
       360        370        380        390        400
APHPERRPNG YALGLVSGGS AQESQGNTGL PDVELLSHEL KGVCPEPPGL 
       410 
DDPLAQDGAG VS                                          

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Chemistry databases

Protein family/group databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ