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UniProtKB - X5DNB4 (X5DNB4_HUMAN)
Protein
Adenosine receptor A2
Gene
ADORA2A
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
UniRule annotationGO - Molecular functioni
- alpha-actinin binding Source: Ensembl
- G protein-coupled adenosine receptor activity Source: UniProtKB-UniRule
- protein-containing complex binding Source: Ensembl
- type 5 metabotropic glutamate receptor binding Source: Ensembl
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: Ensembl
- astrocyte activation Source: Ensembl
- eating behavior Source: Ensembl
- excitatory postsynaptic potential Source: Ensembl
- inhibitory postsynaptic potential Source: Ensembl
- locomotory behavior Source: Ensembl
- membrane depolarization Source: Ensembl
- negative regulation of alpha-beta T cell activation Source: Ensembl
- negative regulation of cell population proliferation Source: Ensembl
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
- negative regulation of inflammatory response Source: Ensembl
- negative regulation of locomotion Source: Ensembl
- negative regulation of neuron apoptotic process Source: Ensembl
- negative regulation of protein kinase activity Source: Ensembl
- negative regulation of vascular permeability Source: Ensembl
- neuron projection morphogenesis Source: Ensembl
- positive regulation of acetylcholine secretion, neurotransmission Source: Ensembl
- positive regulation of apoptotic signaling pathway Source: Ensembl
- positive regulation of circadian sleep/wake cycle, sleep Source: Ensembl
- positive regulation of glutamate secretion Source: Ensembl
- positive regulation of long-term synaptic potentiation Source: Ensembl
- positive regulation of protein secretion Source: Ensembl
- positive regulation of renal sodium excretion Source: Ensembl
- positive regulation of synaptic transmission, GABAergic Source: Ensembl
- positive regulation of synaptic transmission, glutamatergic Source: Ensembl
- positive regulation of urine volume Source: Ensembl
- prepulse inhibition Source: Ensembl
- protein kinase C-activating G protein-coupled receptor signaling pathway Source: Ensembl
- regulation of calcium ion transport Source: Ensembl
- regulation of mitochondrial membrane potential Source: Ensembl
- regulation of norepinephrine secretion Source: Ensembl
- regulation of synaptic vesicle exocytosis Source: Ensembl
- regulation of transcription, DNA-templated Source: Ensembl
- response to amphetamine Source: Ensembl
- response to caffeine Source: Ensembl
- response to xenobiotic stimulus Source: Ensembl
- synaptic transmission, cholinergic Source: Ensembl
- synaptic transmission, dopaminergic Source: Ensembl
- synaptic transmission, glutamatergic Source: Ensembl
- vasodilation Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptorUniRule annotation, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: Adenosine receptor A2UniRule annotation |
Gene namesi | Name:ADORA2AImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000128271 |
Subcellular locationi
Plasma membrane
- Cell membrane UniRule annotationARBA annotation; Multi-pass membrane protein UniRule annotationARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Cytoskeleton
- intermediate filament Source: Ensembl
Plasma Membrane
- axolemma Source: Ensembl
- integral component of postsynaptic membrane Source: Ensembl
- integral component of presynaptic membrane Source: Ensembl
Other locations
- dendrite Source: Ensembl
- endomembrane system Source: Ensembl
- glutamatergic synapse Source: Ensembl
- neuronal cell body Source: Ensembl
- postsynaptic density Source: Ensembl
- presynaptic active zone Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 6 – 32 | HelicalUniRule annotationAdd BLAST | 27 | |
Transmembranei | 44 – 66 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 78 – 100 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 121 – 143 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 178 – 202 | HelicalUniRule annotationAdd BLAST | 25 | |
Transmembranei | 235 – 258 | HelicalUniRule annotationAdd BLAST | 24 | |
Transmembranei | 270 – 290 | HelicalUniRule annotationAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membraneUniRule annotation, MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000128271, Expressed in cerebellum and 115 other tissues |
ExpressionAtlasi | X5DNB4, baseline and differential |
Interactioni
GO - Molecular functioni
- alpha-actinin binding Source: Ensembl
- type 5 metabotropic glutamate receptor binding Source: Ensembl
Chemistry databases
BindingDBi | X5DNB4 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 288 | G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST | 266 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 391 – 412 | DisorderedSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
OMAi | YTNGEIH |
OrthoDBi | 550297at2759 |
PhylomeDBi | X5DNB4 |
Family and domain databases
InterProi | View protein in InterPro IPR001513, Adeno_A2A_rcpt IPR001634, Adenosn_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00553, ADENOSINA2AR PR00424, ADENOSINER PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Fragment.
X5DNB4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPIMGSSVYI TVELAIAVLA ILGNVLVCWA VWLNSNLQNV TNYFVVSLAA
60 70 80 90 100
ADIAVGVLAI PFAITISTGF CAACHGCLFI ACFVLVLTQS SIFSLLAIAI
110 120 130 140 150
DRYIAIRIPL RYNGLVTGTR AKGIIAICWV LSFAIGLTPM LGWNNCGQPK
160 170 180 190 200
EGKNHSQGCG EGQVACLFED VVPMNYMVYF NFFACVLVPL LLMLGVYLRI
210 220 230 240 250
FLAARRQLKQ MESQPLPGER ARSTLQKEVH AAKSLAIIVG LFALCWLPLH
260 270 280 290 300
IINCFTFFCP DCSHAPLWLM YLAIVLSHTN SVVNPFIYAY RIREFRQTFR
310 320 330 340 350
KIIRSHVLRQ QEPFKAAGTS ARVLAAHGSD GEQVSLRLNG HPPGVWANGS
360 370 380 390 400
APHPERRPNG YALGLVSGGS AQESQGNTGL PDVELLSHEL KGVCPEPPGL
410
DDPLAQDGAG VS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 412 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KJ534761 mRNA Translation: AHW56401.1 |
RefSeqi | NP_000666.2, NM_000675.5 NP_001265426.1, NM_001278497.1 NP_001265427.1, NM_001278498.1 NP_001265428.1, NM_001278499.1 NP_001265429.1, NM_001278500.1 |
Genome annotation databases
GeneIDi | 135 |
KEGGi | hsa:135 |
MANE-Selecti | ENST00000337539.12; ENSP00000336630.6; NM_000675.6; NP_000666.2 |
UCSCi | uc002zzy.6, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KJ534761 mRNA Translation: AHW56401.1 |
RefSeqi | NP_000666.2, NM_000675.5 NP_001265426.1, NM_001278497.1 NP_001265427.1, NM_001278498.1 NP_001265428.1, NM_001278499.1 NP_001265429.1, NM_001278500.1 |
3D structure databases
SMRi | X5DNB4 |
ModBasei | Search... |
Chemistry databases
BindingDBi | X5DNB4 |
Protein family/group databases
GPCRDBi | Search... |
Protocols and materials databases
Antibodypediai | 9718, 448 antibodies from 40 providers |
DNASUi | 135 |
Genome annotation databases
GeneIDi | 135 |
KEGGi | hsa:135 |
MANE-Selecti | ENST00000337539.12; ENSP00000336630.6; NM_000675.6; NP_000666.2 |
UCSCi | uc002zzy.6, human |
Organism-specific databases
CTDi | 135 |
VEuPathDBi | HostDB:ENSG00000128271 |
Phylogenomic databases
OMAi | YTNGEIH |
OrthoDBi | 550297at2759 |
PhylomeDBi | X5DNB4 |
Miscellaneous databases
BioGRID-ORCSi | 135, 7 hits in 1038 CRISPR screens |
GenomeRNAii | 135 |
Gene expression databases
Bgeei | ENSG00000128271, Expressed in cerebellum and 115 other tissues |
ExpressionAtlasi | X5DNB4, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR001513, Adeno_A2A_rcpt IPR001634, Adenosn_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00553, ADENOSINA2AR PR00424, ADENOSINER PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | X5DNB4_HUMAN | |
Accessioni | X5DNB4Primary (citable) accession number: X5DNB4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 11, 2014 |
Last sequence update: | June 11, 2014 | |
Last modified: | January 19, 2022 | |
This is version 56 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |