UniProtKB - X5D8S1 (X5D8S1_HUMAN)
Protein
(S)-3-amino-2-methylpropionate transaminase
Gene
ABAT
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- (S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamateARBA annotationEC:2.6.1.22ARBA annotation
- EC:2.6.1.19ARBA annotation
Cofactori
pyridoxal 5'-phosphateARBA annotation
GO - Molecular functioni
- (S)-3-amino-2-methylpropionate transaminase activity Source: UniProtKB-EC
- 4-aminobutyrate:2-oxoglutarate transaminase activity Source: UniProtKB-EC
- pyridoxal phosphate binding Source: InterPro
GO - Biological processi
- gamma-aminobutyric acid metabolic process Source: InterPro
- neurotransmitter catabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | AminotransferaseImported, Transferase |
Biological process | Neurotransmitter degradationARBA annotation |
Ligand | Pyridoxal phosphateUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: (S)-3-amino-2-methylpropionate transaminaseARBA annotation (EC:2.6.1.19ARBA annotation, EC:2.6.1.22ARBA annotation)Alternative name(s): 4-aminobutyrate aminotransferase, mitochondrialARBA annotation GABA aminotransferaseARBA annotation Gamma-amino-N-butyrate transaminaseARBA annotation L-AIBATARBA annotation |
Gene namesi | Name:ABATImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000183044.11 |
Subcellular locationi
Mitochondrion
- mitochondrion Source: HPA
Keywords - Cellular componenti
MitochondrionARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000183044, Expressed in substantia nigra and 241 other tissues |
ExpressionAtlasi | X5D8S1, baseline and differential |
Interactioni
Subunit structurei
Homodimer; disulfide-linked.
ARBA annotationChemistry databases
BindingDBi | X5D8S1 |
Family & Domainsi
Sequence similaritiesi
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.UniRule annotationARBA annotation
Phylogenomic databases
HOGENOMi | CLU_016922_12_1_1 |
OrthoDBi | 566705at2759 |
PhylomeDBi | X5D8S1 |
Family and domain databases
CDDi | cd00610, OAT_like, 1 hit |
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
InterProi | View protein in InterPro IPR004631, 4NH2But_aminotransferase_euk IPR005814, Aminotrans_3 IPR015424, PyrdxlP-dep_Trfase IPR015422, PyrdxlP-dep_Trfase_dom1 IPR015421, PyrdxlP-dep_Trfase_major |
Pfami | View protein in Pfam PF00202, Aminotran_3, 1 hit |
PIRSFi | PIRSF000521, Transaminase_4ab_Lys_Orn, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
TIGRFAMsi | TIGR00699, GABAtrns_euk, 1 hit |
PROSITEi | View protein in PROSITE PS00600, AA_TRANSFER_CLASS_3, 1 hit |
i Sequence
Sequence statusi: Fragment.
X5D8S1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASMLLAQRL ACSFQHSYRL LVPGSRHISQ AAAKVDVEFD YDGPLMKTEV
60 70 80 90 100
PGPRSQELMK QLNIIQNAEA VHFFCNYEES RGNYLVDVDG NRMLDLYSQI
110 120 130 140 150
SSVPIGYSHP ALLKLIQQPQ NASMFVNRPA LGILPPENFV EKLRQSLLSV
160 170 180 190 200
APKGMSQLIT MACGSCSNEN ALKTIFMWYR SKERGQRGFS QEELETCMIN
210 220 230 240 250
QAPGCPDYSI LSFMGAFHGR TMGCLATTHS KAIHKIDIPS FDWPIAPFPR
260 270 280 290 300
LKYPLEEFVK ENQQEEARCL EEVEDLIVKY RKKKKTVAGI IVEPIQSEGG
310 320 330 340 350
DNHASDDFFR KLRDIARKHG CAFLVDEVQT GGGCTGKFWA HEHWGLDDPA
360 370 380 390 400
DVMTFSKKMM TGGFFHKEEF RPNAPYRIFN TWLGDPSKNL LLAEVINIIK
410 420 430 440 450
REDLLNNAAH AGKALLTGLL DLQARYPQFI SRVRGRGTFC SFDTPDDSIR
460 470 480 490 500
NKLILIARNK GVVLGGCGDK SIRFRPTLVF RDHHAHLFLN IFSDILADFK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 500 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KJ534758 mRNA Translation: AHW56398.1 |
RefSeqi | NP_000654.2, NM_000663.4 NP_001120920.1, NM_001127448.1 NP_065737.2, NM_020686.5 XP_011520702.1, XM_011522400.2 XP_011520703.1, XM_011522401.2 |
Genome annotation databases
GeneIDi | 18 |
KEGGi | hsa:18 |
UCSCi | uc002czc.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KJ534758 mRNA Translation: AHW56398.1 |
RefSeqi | NP_000654.2, NM_000663.4 NP_001120920.1, NM_001127448.1 NP_065737.2, NM_020686.5 XP_011520702.1, XM_011522400.2 XP_011520703.1, XM_011522401.2 |
3D structure databases
SMRi | X5D8S1 |
ModBasei | Search... |
Chemistry databases
BindingDBi | X5D8S1 |
Proteomic databases
MaxQBi | X5D8S1 |
Protocols and materials databases
Antibodypediai | 24533, 332 antibodies |
Genome annotation databases
GeneIDi | 18 |
KEGGi | hsa:18 |
UCSCi | uc002czc.5, human |
Organism-specific databases
CTDi | 18 |
VEuPathDBi | HostDB:ENSG00000183044.11 |
Phylogenomic databases
HOGENOMi | CLU_016922_12_1_1 |
OrthoDBi | 566705at2759 |
PhylomeDBi | X5D8S1 |
Miscellaneous databases
BioGRID-ORCSi | 18, 1 hit in 876 CRISPR screens |
ChiTaRSi | ABAT, human |
GenomeRNAii | 18 |
Gene expression databases
Bgeei | ENSG00000183044, Expressed in substantia nigra and 241 other tissues |
ExpressionAtlasi | X5D8S1, baseline and differential |
Family and domain databases
CDDi | cd00610, OAT_like, 1 hit |
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
InterProi | View protein in InterPro IPR004631, 4NH2But_aminotransferase_euk IPR005814, Aminotrans_3 IPR015424, PyrdxlP-dep_Trfase IPR015422, PyrdxlP-dep_Trfase_dom1 IPR015421, PyrdxlP-dep_Trfase_major |
Pfami | View protein in Pfam PF00202, Aminotran_3, 1 hit |
PIRSFi | PIRSF000521, Transaminase_4ab_Lys_Orn, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
TIGRFAMsi | TIGR00699, GABAtrns_euk, 1 hit |
PROSITEi | View protein in PROSITE PS00600, AA_TRANSFER_CLASS_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | X5D8S1_HUMAN | |
Accessioni | X5D8S1Primary (citable) accession number: X5D8S1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 11, 2014 |
Last sequence update: | June 11, 2014 | |
Last modified: | February 10, 2021 | |
This is version 39 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |