UniProtKB - X5D7I5 (X5D7I5_HUMAN)
Protein
5-hydroxytryptamine receptor 1B
Gene
HTR1B
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- drug binding Source: Ensembl
- G protein-coupled serotonin receptor activity Source: Ensembl
- serotonin binding Source: Ensembl
- voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels Source: Ensembl
GO - Biological processi
- bone remodeling Source: Ensembl
- cellular response to temperature stimulus Source: Ensembl
- chemical synaptic transmission Source: Ensembl
- drinking behavior Source: Ensembl
- G protein-coupled receptor internalization Source: Ensembl
- negative regulation of gamma-aminobutyric acid secretion Source: Ensembl
- negative regulation of serotonin secretion Source: Ensembl
- negative regulation of synaptic transmission, GABAergic Source: Ensembl
- negative regulation of synaptic transmission, glutamatergic Source: Ensembl
- protein kinase C-activating G protein-coupled receptor signaling pathway Source: Ensembl
- regulation of behavior Source: InterPro
- regulation of dopamine secretion Source: Ensembl
- response to cocaine Source: Ensembl
- response to ethanol Source: Ensembl
- response to mineralocorticoid Source: Ensembl
- vasoconstriction Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptorUniRule annotationARBA annotation, Receptor, Transducer |
Biological process | BehaviorARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: 5-hydroxytryptamine receptor 1BARBA annotationAlternative name(s): Serotonin receptor 1BARBA annotation |
Gene namesi | Name:HTR1BImported ORF Names:hCG_32414Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000135312.5 |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- integral component of presynaptic membrane Source: Ensembl
- plasma membrane Source: HPA
Other locations
- calyx of Held Source: Ensembl
- cytoplasm Source: Ensembl
- G protein-coupled serotonin receptor complex Source: Ensembl
- serotonergic synapse Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 50 – 74 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 86 – 105 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 125 – 145 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 166 – 186 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 206 – 228 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 315 – 339 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 345 – 364 | HelicalSequence analysisAdd BLAST | 20 |
Keywords - Cellular componenti
Cell membraneARBA annotation, MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000135312, Expressed in popliteal artery and 94 other tissues |
ExpressionAtlasi | X5D7I5, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 66 – 369 | G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST | 304 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 259 – 281 | DisorderedSequence analysisAdd BLAST | 23 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
HOGENOMi | CLU_009579_11_1_1 |
OMAi | ACWFHMA |
OrthoDBi | 703991at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR002147, 5HT1B_rcpt IPR002231, 5HT_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
PANTHERi | PTHR24247:SF16, PTHR24247:SF16, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00513, 5HT1BRECEPTR PR01101, 5HTRECEPTOR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Fragment.
X5D7I5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEEPGAQCAP PPPAGSETWV PQANLSSAPS QNCSAKDYIY QDSISLPWKV
60 70 80 90 100
LLVMLLALIT LATTLSNAFV IATVYRTRKL HTPANYLIAS LAVTDLLVSI
110 120 130 140 150
LVMPISTMYT VTGRWTLGQV VCDFWLSSDI TCCTASILHL CVIALDRYWA
160 170 180 190 200
ITDAVEYSAK RTPKRAAVMI ALVWVFSISI SLPPFFWRQA KAEEEVSECV
210 220 230 240 250
VNTDHILYTV YSTVGAFYFP TLLLIALYGR IYVEARSRIL KQTPNRTGKR
260 270 280 290 300
LTRAQLITDS PGSTSSVTSI NSRVPDVPSE SGSPVYVNQV KVRVSDALLE
310 320 330 340 350
KKKLMAARER KATKTLGIIL GAFIVCWLPF FIISLVMPIC KDACWFHLAI
360 370 380 390
FDFFTWLGYL NSLINPIIYT MSNEDFKQAF HKLIRFKCTS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 390 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KJ534870 mRNA Translation: AHW56510.1 CH471051 Genomic DNA Translation: EAW48722.1 |
RefSeqi | NP_000854.1, NM_000863.2 |
Genome annotation databases
GeneIDi | 3351 |
KEGGi | hsa:3351 |
UCSCi | uc003pil.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KJ534870 mRNA Translation: AHW56510.1 CH471051 Genomic DNA Translation: EAW48722.1 |
RefSeqi | NP_000854.1, NM_000863.2 |
3D structure databases
SMRi | X5D7I5 |
ModBasei | Search... |
Chemistry databases
BindingDBi | X5D7I5 |
Protein family/group databases
GPCRDBi | Search... |
Protocols and materials databases
Antibodypediai | 18374, 284 antibodies |
Genome annotation databases
GeneIDi | 3351 |
KEGGi | hsa:3351 |
UCSCi | uc003pil.2, human |
Organism-specific databases
CTDi | 3351 |
EuPathDBi | HostDB:ENSG00000135312.5 |
Phylogenomic databases
HOGENOMi | CLU_009579_11_1_1 |
OMAi | ACWFHMA |
OrthoDBi | 703991at2759 |
Miscellaneous databases
BioGRID-ORCSi | 3351, 9 hits in 843 CRISPR screens |
GenomeRNAii | 3351 |
Gene expression databases
Bgeei | ENSG00000135312, Expressed in popliteal artery and 94 other tissues |
ExpressionAtlasi | X5D7I5, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR002147, 5HT1B_rcpt IPR002231, 5HT_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
PANTHERi | PTHR24247:SF16, PTHR24247:SF16, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00513, 5HT1BRECEPTR PR01101, 5HTRECEPTOR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | X5D7I5_HUMAN | |
Accessioni | X5D7I5Primary (citable) accession number: X5D7I5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 11, 2014 |
Last sequence update: | June 11, 2014 | |
Last modified: | December 2, 2020 | |
This is version 57 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |