UniProtKB - X5D2B0 (X5D2B0_HUMAN)
Protein
Vasopressin V1a receptor
Gene
AVPR1A
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.UniRule annotation
GO - Molecular functioni
- peptide hormone binding Source: Ensembl
- V1A vasopressin receptor binding Source: Ensembl
- vasopressin receptor activity Source: UniProtKB-UniRule
GO - Biological processi
- calcium-mediated signaling Source: Ensembl
- cellular response to water deprivation Source: Ensembl
- grooming behavior Source: Ensembl
- maternal aggressive behavior Source: Ensembl
- maternal behavior Source: Ensembl
- myotube differentiation Source: Ensembl
- negative regulation of female receptivity Source: Ensembl
- negative regulation of transmission of nerve impulse Source: Ensembl
- penile erection Source: Ensembl
- positive regulation of cell growth Source: Ensembl
- positive regulation of cell population proliferation Source: Ensembl
- positive regulation of cellular pH reduction Source: Ensembl
- positive regulation of cytosolic calcium ion concentration Source: Ensembl
- positive regulation of glutamate secretion Source: Ensembl
- positive regulation of heart rate Source: Ensembl
- positive regulation of prostaglandin biosynthetic process Source: Ensembl
- positive regulation of renal sodium excretion Source: Ensembl
- positive regulation of systemic arterial blood pressure Source: Ensembl
- positive regulation of vasoconstriction Source: Ensembl
- regulation of systemic arterial blood pressure by vasopressin Source: Ensembl
- response to corticosterone Source: Ensembl
- social behavior Source: Ensembl
- sperm ejaculation Source: Ensembl
- telencephalon development Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptorUniRule annotation, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: Vasopressin V1a receptorUniRule annotation |
Gene namesi | Name:AVPR1AImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000166148.3 |
Subcellular locationi
Plasma membrane
- Cell membrane UniRule annotationARBA annotation; Multi-pass membrane protein UniRule annotationARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- cytoplasmic vesicle Source: Ensembl
- integral component of membrane Source: UniProtKB-UniRule
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 55 – 76 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 88 – 106 | HelicalUniRule annotationAdd BLAST | 19 | |
Transmembranei | 126 – 148 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 169 – 189 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 219 – 244 | HelicalUniRule annotationAdd BLAST | 26 | |
Transmembranei | 290 – 310 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 330 – 351 | HelicalUniRule annotationAdd BLAST | 22 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000166148, Expressed in adrenal gland and 168 other tissues |
ExpressionAtlasi | X5D2B0, baseline and differential |
Interactioni
GO - Molecular functioni
- V1A vasopressin receptor binding Source: Ensembl
Chemistry databases
BindingDBi | X5D2B0 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 68 – 348 | G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST | 281 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 43 | DisorderedSequence analysisAdd BLAST | 43 | |
Regioni | 377 – 410 | DisorderedSequence analysisAdd BLAST | 34 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 383 – 410 | PolarSequence analysisAdd BLAST | 28 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
HOGENOMi | CLU_009579_15_3_1 |
OMAi | RFRGPDW |
OrthoDBi | 890925at2759 |
PhylomeDBi | X5D2B0 |
Family and domain databases
InterProi | View protein in InterPro IPR015076, DUF1856 IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR001817, Vasoprsn_rcpt IPR001224, Vprs_V1A_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit PF08983, DUF1856, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00896, VASOPRESSINR PR00752, VASOPRSNV1AR |
SMARTi | View protein in SMART SM01164, DUF1856, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Fragment.
X5D2B0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRLSAGPDAG PSGNSSPWWP LATGAGNTSR EAEALGEGNG PPRDVRNEEL
60 70 80 90 100
AKLEIAVLAV TFAVAVLGNS SVLLALHRTP RKTSRMHLFI RHLSLADLAV
110 120 130 140 150
AFFQVLPQMC WDITYRFRGP DWLCRVVKHL QVFGMFASAY MLVVMTADRY
160 170 180 190 200
IAVCHPLKTL QQPARRSRLM IAAAWVLSFV LSTPQYFVFS MIEVNNVTKA
210 220 230 240 250
RDCWATFIQP WGSRAYVTWM TGGIFVAPVV ILGTCYGFIC YNIWCNVRGK
260 270 280 290 300
TASRQSKGAE QAGVAFQKGF LLAPCVSSVK SISRAKIRTV KMTFVIVTAY
310 320 330 340 350
IVCWAPFFII QMWSVWDPMS VWTESENPTI TITALLGSLN SCCNPWIYMF
360 370 380 390 400
FSGHLLQDCV QSFPCCQNMK EKFNKEDTDS MSRRQTFYSN NRSPTNSTGM
410
WKDSPKSSKS IKFIPVST
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 418 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KJ534779 mRNA Translation: AHW56419.1 |
RefSeqi | NP_000697.1, NM_000706.4 |
Genome annotation databases
GeneIDi | 552 |
KEGGi | hsa:552 |
UCSCi | uc001sro.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KJ534779 mRNA Translation: AHW56419.1 |
RefSeqi | NP_000697.1, NM_000706.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Chemistry databases
BindingDBi | X5D2B0 |
Protein family/group databases
GPCRDBi | Search... |
Protocols and materials databases
Antibodypediai | 29106, 284 antibodies |
Genome annotation databases
GeneIDi | 552 |
KEGGi | hsa:552 |
UCSCi | uc001sro.3, human |
Organism-specific databases
CTDi | 552 |
VEuPathDBi | HostDB:ENSG00000166148.3 |
Phylogenomic databases
HOGENOMi | CLU_009579_15_3_1 |
OMAi | RFRGPDW |
OrthoDBi | 890925at2759 |
PhylomeDBi | X5D2B0 |
Miscellaneous databases
BioGRID-ORCSi | 552, 42 hits in 874 CRISPR screens |
ChiTaRSi | AVPR1A, human |
GenomeRNAii | 552 |
Gene expression databases
Bgeei | ENSG00000166148, Expressed in adrenal gland and 168 other tissues |
ExpressionAtlasi | X5D2B0, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR015076, DUF1856 IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR001817, Vasoprsn_rcpt IPR001224, Vprs_V1A_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit PF08983, DUF1856, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00896, VASOPRESSINR PR00752, VASOPRSNV1AR |
SMARTi | View protein in SMART SM01164, DUF1856, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | X5D2B0_HUMAN | |
Accessioni | X5D2B0Primary (citable) accession number: X5D2B0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 11, 2014 |
Last sequence update: | June 11, 2014 | |
Last modified: | February 10, 2021 | |
This is version 44 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |