UniProtKB - X5CKE2 (X5CKE2_HUMAN)
Protein
Submitted name:
HLA class II histocompatibility antigen DP alpha chain
Gene
HLA-DPA1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Source: UniProtKB-KW
Keywordsi
Biological process | Adaptive immunity, Immunity |
Names & Taxonomyi
Protein namesi | Submitted name: HLA class II histocompatibility antigen DP alpha chainImportedSubmitted name: HLA-DPA1*01:03:01:NewImportedSubmitted name: MHC class II antigenImportedSubmitted name: Major histocompatibility complex, class II, DP alpha 1, isoform CRA_aImported |
Gene namesi | Name:HLA-DPA1Imported Synonyms:HLA-DPAImported ORF Names:hCG_1644130Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000231389.7 |
Subcellular locationi
Endosome
- Endosome membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Lysosome
- Lysosome membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Endosome
- endosome membrane Source: UniProtKB-SubCell
Lysosome
- lysosomal membrane Source: UniProtKB-SubCell
Plasma Membrane
- MHC class II protein complex Source: UniProtKB-KW
Other locations
- integral component of membrane Source: UniProtKB-KW
- intracellular membrane-bounded organelle Source: HPA
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 227 – 245 | HelicalSequence analysisAdd BLAST | 19 |
Keywords - Cellular componenti
EndosomeARBA annotation, LysosomeARBA annotation, Membrane, MHC IIARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 31 | Sequence analysisAdd BLAST | 31 | |
ChainiPRO_5014316166 | 32 – 260 | Sequence analysisAdd BLAST | 229 |
Keywords - PTMi
Disulfide bondARBA annotation, GlycoproteinARBA annotationProteomic databases
MaxQBi | X5CKE2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000231389, Expressed in visceral pleura and 246 other tissues |
ExpressionAtlasi | X5CKE2, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 118 – 198 | Ig-likeInterPro annotationAdd BLAST | 81 |
Sequence similaritiesi
Belongs to the MHC class II family.UniRule annotation
Keywords - Domaini
SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
HOGENOMi | CLU_069380_0_0_1 |
OMAi | TVWHLPE |
OrthoDBi | 1132781at2759 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.10.320.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011162, MHC_I/II-like_Ag-recog IPR014745, MHC_II_a/b_N IPR001003, MHC_II_a_N |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00993, MHC_II_alpha, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit SM00920, MHC_II_alpha, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
i Sequence
Sequence statusi: Complete.
X5CKE2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRPEDRMFHI RAVILRALSL AFLLSLRGAG AIKADHVSTY AAFVQTHRPT
60 70 80 90 100
GEFMFEFDED EMFYVDLDKK ETVWHLEEFG QAFSFEAQGG LANIAILNNN
110 120 130 140 150
LNTLIQRSNH TQATNDPPEV TVFPKEPVEL GQPNTLICHI DKFFPPVLNV
160 170 180 190 200
TWLCNGELVT EGVAESLFLP RTDYSFHKFH YLTFVPSAED FYDCRVEHWG
210 220 230 240 250
LDQPLLKHWE AQEPIQMPET TETVLCALGL VLGLVGIIVG TVLIIKSLRS
260
GHDPRAQGTL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KJ657695 Genomic DNA Translation: AHW47949.1 KJ657697 Genomic DNA Translation: AHW47983.1 KT716045 Genomic DNA Translation: AML03230.1 KT716047 Genomic DNA Translation: AML03232.1 KT716052 Genomic DNA Translation: AML03237.1 KT735120 Genomic DNA Translation: AML47709.1 KT735121 Genomic DNA Translation: AML47710.1 KT735122 Genomic DNA Translation: AML47711.1 MF568069 Genomic DNA Translation: ATG70532.1 MH536738 Genomic DNA Translation: AXP20276.1 LC257878 Genomic DNA Translation: BBD34196.1 LC257879 Genomic DNA Translation: BBD34197.1 LC257880 Genomic DNA Translation: BBD34198.1 LC257881 Genomic DNA Translation: BBD34199.1 LC257882 Genomic DNA Translation: BBD34200.1 LC257883 Genomic DNA Translation: BBD34201.1 LC257884 Genomic DNA Translation: BBD34202.1 LC257885 Genomic DNA Translation: BBD34203.1 CH471081 Genomic DNA Translation: EAX03670.1 CH471081 Genomic DNA Translation: EAX03671.1 MH716395 Genomic DNA Translation: QBQ57802.1 MH716396 Genomic DNA Translation: QBQ57803.1 MH716397 Genomic DNA Translation: QBQ57804.1 MH920368 Genomic DNA Translation: QBQ58338.1 MH753031 Genomic DNA Translation: QBQ82073.1 MH753038 Genomic DNA Translation: QBQ82080.1 MH892057 Genomic DNA Translation: QCF28405.1 MH892058 Genomic DNA Translation: QCF28406.1 MH892062 Genomic DNA Translation: QCF28410.1 MK610127 Genomic DNA Translation: QCY59257.1 MK541690 Genomic DNA Translation: QCZ35092.1 MK541693 Genomic DNA Translation: QCZ35095.1 MN013152 Genomic DNA Translation: QDB06027.1 MK501647 Genomic DNA Translation: QDB65107.1 MK170168 Genomic DNA Translation: QDC22497.1 MK170169 Genomic DNA Translation: QDC22498.1 MK170170 Genomic DNA Translation: QDC22499.1 MN153774 Genomic DNA Translation: QFQ66434.1 MN093121 Genomic DNA Translation: QFR42334.1 MN889876 Genomic DNA Translation: QHR76767.1 MN208452 Genomic DNA Translation: QIB00613.1 MN208444 Genomic DNA Translation: QIB00616.1 MN208446 Genomic DNA Translation: QIB00617.1 MN606324 Genomic DNA Translation: QJI80923.1 MT071115 Genomic DNA Translation: QJX19972.1 MN481211 Genomic DNA Translation: QJX19983.1 |
RefSeqi | NP_001229453.1, NM_001242524.1 NP_001229454.1, NM_001242525.1 NP_291032.2, NM_033554.3 |
Genome annotation databases
GeneIDi | 3113 |
KEGGi | hsa:3113 |
UCSCi | uc021ywg.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KJ657695 Genomic DNA Translation: AHW47949.1 KJ657697 Genomic DNA Translation: AHW47983.1 KT716045 Genomic DNA Translation: AML03230.1 KT716047 Genomic DNA Translation: AML03232.1 KT716052 Genomic DNA Translation: AML03237.1 KT735120 Genomic DNA Translation: AML47709.1 KT735121 Genomic DNA Translation: AML47710.1 KT735122 Genomic DNA Translation: AML47711.1 MF568069 Genomic DNA Translation: ATG70532.1 MH536738 Genomic DNA Translation: AXP20276.1 LC257878 Genomic DNA Translation: BBD34196.1 LC257879 Genomic DNA Translation: BBD34197.1 LC257880 Genomic DNA Translation: BBD34198.1 LC257881 Genomic DNA Translation: BBD34199.1 LC257882 Genomic DNA Translation: BBD34200.1 LC257883 Genomic DNA Translation: BBD34201.1 LC257884 Genomic DNA Translation: BBD34202.1 LC257885 Genomic DNA Translation: BBD34203.1 CH471081 Genomic DNA Translation: EAX03670.1 CH471081 Genomic DNA Translation: EAX03671.1 MH716395 Genomic DNA Translation: QBQ57802.1 MH716396 Genomic DNA Translation: QBQ57803.1 MH716397 Genomic DNA Translation: QBQ57804.1 MH920368 Genomic DNA Translation: QBQ58338.1 MH753031 Genomic DNA Translation: QBQ82073.1 MH753038 Genomic DNA Translation: QBQ82080.1 MH892057 Genomic DNA Translation: QCF28405.1 MH892058 Genomic DNA Translation: QCF28406.1 MH892062 Genomic DNA Translation: QCF28410.1 MK610127 Genomic DNA Translation: QCY59257.1 MK541690 Genomic DNA Translation: QCZ35092.1 MK541693 Genomic DNA Translation: QCZ35095.1 MN013152 Genomic DNA Translation: QDB06027.1 MK501647 Genomic DNA Translation: QDB65107.1 MK170168 Genomic DNA Translation: QDC22497.1 MK170169 Genomic DNA Translation: QDC22498.1 MK170170 Genomic DNA Translation: QDC22499.1 MN153774 Genomic DNA Translation: QFQ66434.1 MN093121 Genomic DNA Translation: QFR42334.1 MN889876 Genomic DNA Translation: QHR76767.1 MN208452 Genomic DNA Translation: QIB00613.1 MN208444 Genomic DNA Translation: QIB00616.1 MN208446 Genomic DNA Translation: QIB00617.1 MN606324 Genomic DNA Translation: QJI80923.1 MT071115 Genomic DNA Translation: QJX19972.1 MN481211 Genomic DNA Translation: QJX19983.1 |
RefSeqi | NP_001229453.1, NM_001242524.1 NP_001229454.1, NM_001242525.1 NP_291032.2, NM_033554.3 |
3D structure databases
SMRi | X5CKE2 |
ModBasei | Search... |
Proteomic databases
MaxQBi | X5CKE2 |
Protocols and materials databases
Antibodypediai | 45587, 299 antibodies |
Genome annotation databases
GeneIDi | 3113 |
KEGGi | hsa:3113 |
UCSCi | uc021ywg.2, human |
Organism-specific databases
CTDi | 3113 |
VEuPathDBi | HostDB:ENSG00000231389.7 |
Phylogenomic databases
HOGENOMi | CLU_069380_0_0_1 |
OMAi | TVWHLPE |
OrthoDBi | 1132781at2759 |
Miscellaneous databases
BioGRID-ORCSi | 3113, 4 hits in 866 CRISPR screens |
ChiTaRSi | HLA-DPA1, human |
GenomeRNAii | 3113 |
Gene expression databases
Bgeei | ENSG00000231389, Expressed in visceral pleura and 246 other tissues |
ExpressionAtlasi | X5CKE2, baseline and differential |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.10.320.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011162, MHC_I/II-like_Ag-recog IPR014745, MHC_II_a/b_N IPR001003, MHC_II_a_N |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00993, MHC_II_alpha, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit SM00920, MHC_II_alpha, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | X5CKE2_HUMAN | |
Accessioni | X5CKE2Primary (citable) accession number: X5CKE2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 11, 2014 |
Last sequence update: | June 11, 2014 | |
Last modified: | February 10, 2021 | |
This is version 62 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |