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UniProtKB - X5CKE2 (X5CKE2_HUMAN)

Entry version 62 (10 Feb 2021)
Sequence version 1 (11 Jun 2014)
Previous versions | rss
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Protein
Submitted name:

HLA class II histocompatibility antigen DP alpha chain

Gene

HLA-DPA1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAdaptive immunity, Immunity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
HLA class II histocompatibility antigen DP alpha chainImported
Submitted name:
HLA-DPA1*01:03:01:NewImported
Submitted name:
MHC class II antigenImported
Submitted name:
Major histocompatibility complex, class II, DP alpha 1, isoform CRA_aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HLA-DPA1Imported
Synonyms:HLA-DPAImported
ORF Names:hCG_1644130Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000231389.7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei227 – 245HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

EndosomeARBA annotation, LysosomeARBA annotation, Membrane, MHC IIARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 31Sequence analysisAdd BLAST31
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501431616632 – 260Sequence analysisAdd BLAST229

Keywords - PTMi

Disulfide bondARBA annotation, GlycoproteinARBA annotation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		X5CKE2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000231389, Expressed in visceral pleura and 246 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		X5CKE2, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		X5CKE2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini118 – 198Ig-likeInterPro annotationAdd BLAST81

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MHC class II family.UniRule annotation

Keywords - Domaini

SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_069380_0_0_1

Identification of Orthologs from Complete Genome Data

More...OMAi		TVWHLPE

Database of Orthologous Groups

More...OrthoDBi		1132781at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 1 hit
3.10.320.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003006, Ig/MHC_CS
IPR003597, Ig_C1-set
IPR011162, MHC_I/II-like_Ag-recog
IPR014745, MHC_II_a/b_N
IPR001003, MHC_II_a_N

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07654, C1-set, 1 hit
PF00993, MHC_II_alpha, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00407, IGc1, 1 hit
SM00920, MHC_II_alpha, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 1 hit
SSF54452, SSF54452, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50835, IG_LIKE, 1 hit
PS00290, IG_MHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

X5CKE2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRPEDRMFHI RAVILRALSL AFLLSLRGAG AIKADHVSTY AAFVQTHRPT 
        60         70         80         90        100
GEFMFEFDED EMFYVDLDKK ETVWHLEEFG QAFSFEAQGG LANIAILNNN 
       110        120        130        140        150
LNTLIQRSNH TQATNDPPEV TVFPKEPVEL GQPNTLICHI DKFFPPVLNV 
       160        170        180        190        200
TWLCNGELVT EGVAESLFLP RTDYSFHKFH YLTFVPSAED FYDCRVEHWG 
       210        220        230        240        250
LDQPLLKHWE AQEPIQMPET TETVLCALGL VLGLVGIIVG TVLIIKSLRS 
       260
GHDPRAQGTL
Length:260
Mass (Da):29,381
Last modified:June 11, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i826174E963A8CB42
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
KJ657695 Genomic DNA Translation: AHW47949.1
KJ657697 Genomic DNA Translation: AHW47983.1
KT716045 Genomic DNA Translation: AML03230.1
KT716047 Genomic DNA Translation: AML03232.1
KT716052 Genomic DNA Translation: AML03237.1
KT735120 Genomic DNA Translation: AML47709.1
KT735121 Genomic DNA Translation: AML47710.1
KT735122 Genomic DNA Translation: AML47711.1
MF568069 Genomic DNA Translation: ATG70532.1
MH536738 Genomic DNA Translation: AXP20276.1
LC257878 Genomic DNA Translation: BBD34196.1
LC257879 Genomic DNA Translation: BBD34197.1
LC257880 Genomic DNA Translation: BBD34198.1
LC257881 Genomic DNA Translation: BBD34199.1
LC257882 Genomic DNA Translation: BBD34200.1
LC257883 Genomic DNA Translation: BBD34201.1
LC257884 Genomic DNA Translation: BBD34202.1
LC257885 Genomic DNA Translation: BBD34203.1
CH471081 Genomic DNA Translation: EAX03670.1
CH471081 Genomic DNA Translation: EAX03671.1
MH716395 Genomic DNA Translation: QBQ57802.1
MH716396 Genomic DNA Translation: QBQ57803.1
MH716397 Genomic DNA Translation: QBQ57804.1
MH920368 Genomic DNA Translation: QBQ58338.1
MH753031 Genomic DNA Translation: QBQ82073.1
MH753038 Genomic DNA Translation: QBQ82080.1
MH892057 Genomic DNA Translation: QCF28405.1
MH892058 Genomic DNA Translation: QCF28406.1
MH892062 Genomic DNA Translation: QCF28410.1
MK610127 Genomic DNA Translation: QCY59257.1
MK541690 Genomic DNA Translation: QCZ35092.1
MK541693 Genomic DNA Translation: QCZ35095.1
MN013152 Genomic DNA Translation: QDB06027.1
MK501647 Genomic DNA Translation: QDB65107.1
MK170168 Genomic DNA Translation: QDC22497.1
MK170169 Genomic DNA Translation: QDC22498.1
MK170170 Genomic DNA Translation: QDC22499.1
MN153774 Genomic DNA Translation: QFQ66434.1
MN093121 Genomic DNA Translation: QFR42334.1
MN889876 Genomic DNA Translation: QHR76767.1
MN208452 Genomic DNA Translation: QIB00613.1
MN208444 Genomic DNA Translation: QIB00616.1
MN208446 Genomic DNA Translation: QIB00617.1
MN606324 Genomic DNA Translation: QJI80923.1
MT071115 Genomic DNA Translation: QJX19972.1
MN481211 Genomic DNA Translation: QJX19983.1

NCBI Reference Sequences

More...RefSeqi		NP_001229453.1, NM_001242524.1
NP_001229454.1, NM_001242525.1
NP_291032.2, NM_033554.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3113

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3113

UCSC genome browser

More...UCSCi		uc021ywg.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KJ657695 Genomic DNA Translation: AHW47949.1
KJ657697 Genomic DNA Translation: AHW47983.1
KT716045 Genomic DNA Translation: AML03230.1
KT716047 Genomic DNA Translation: AML03232.1
KT716052 Genomic DNA Translation: AML03237.1
KT735120 Genomic DNA Translation: AML47709.1
KT735121 Genomic DNA Translation: AML47710.1
KT735122 Genomic DNA Translation: AML47711.1
MF568069 Genomic DNA Translation: ATG70532.1
MH536738 Genomic DNA Translation: AXP20276.1
LC257878 Genomic DNA Translation: BBD34196.1
LC257879 Genomic DNA Translation: BBD34197.1
LC257880 Genomic DNA Translation: BBD34198.1
LC257881 Genomic DNA Translation: BBD34199.1
LC257882 Genomic DNA Translation: BBD34200.1
LC257883 Genomic DNA Translation: BBD34201.1
LC257884 Genomic DNA Translation: BBD34202.1
LC257885 Genomic DNA Translation: BBD34203.1
CH471081 Genomic DNA Translation: EAX03670.1
CH471081 Genomic DNA Translation: EAX03671.1
MH716395 Genomic DNA Translation: QBQ57802.1
MH716396 Genomic DNA Translation: QBQ57803.1
MH716397 Genomic DNA Translation: QBQ57804.1
MH920368 Genomic DNA Translation: QBQ58338.1
MH753031 Genomic DNA Translation: QBQ82073.1
MH753038 Genomic DNA Translation: QBQ82080.1
MH892057 Genomic DNA Translation: QCF28405.1
MH892058 Genomic DNA Translation: QCF28406.1
MH892062 Genomic DNA Translation: QCF28410.1
MK610127 Genomic DNA Translation: QCY59257.1
MK541690 Genomic DNA Translation: QCZ35092.1
MK541693 Genomic DNA Translation: QCZ35095.1
MN013152 Genomic DNA Translation: QDB06027.1
MK501647 Genomic DNA Translation: QDB65107.1
MK170168 Genomic DNA Translation: QDC22497.1
MK170169 Genomic DNA Translation: QDC22498.1
MK170170 Genomic DNA Translation: QDC22499.1
MN153774 Genomic DNA Translation: QFQ66434.1
MN093121 Genomic DNA Translation: QFR42334.1
MN889876 Genomic DNA Translation: QHR76767.1
MN208452 Genomic DNA Translation: QIB00613.1
MN208444 Genomic DNA Translation: QIB00616.1
MN208446 Genomic DNA Translation: QIB00617.1
MN606324 Genomic DNA Translation: QJI80923.1
MT071115 Genomic DNA Translation: QJX19972.1
MN481211 Genomic DNA Translation: QJX19983.1
RefSeqiNP_001229453.1, NM_001242524.1
NP_001229454.1, NM_001242525.1
NP_291032.2, NM_033554.3

3D structure databases

SMRiX5CKE2
ModBaseiSearch...

Proteomic databases

MaxQBiX5CKE2

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		45587, 299 antibodies

Genome annotation databases

GeneIDi3113
KEGGihsa:3113
UCSCiuc021ywg.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3113
VEuPathDBiHostDB:ENSG00000231389.7

Phylogenomic databases

HOGENOMiCLU_069380_0_0_1
OMAiTVWHLPE
OrthoDBi1132781at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3113, 4 hits in 866 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		HLA-DPA1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3113

Gene expression databases

BgeeiENSG00000231389, Expressed in visceral pleura and 246 other tissues
ExpressionAtlasiX5CKE2, baseline and differential

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003006, Ig/MHC_CS
IPR003597, Ig_C1-set
IPR011162, MHC_I/II-like_Ag-recog
IPR014745, MHC_II_a/b_N
IPR001003, MHC_II_a_N
PfamiView protein in Pfam
PF07654, C1-set, 1 hit
PF00993, MHC_II_alpha, 1 hit
SMARTiView protein in SMART
SM00407, IGc1, 1 hit
SM00920, MHC_II_alpha, 1 hit
SUPFAMiSSF48726, SSF48726, 1 hit
SSF54452, SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 1 hit
PS00290, IG_MHC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiX5CKE2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: X5CKE2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 11, 2014
Last sequence update: June 11, 2014
Last modified: February 10, 2021
This is version 62 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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