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Entry version 54 (26 Feb 2020)
Sequence version 1 (11 Jun 2014)
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Protein
Submitted name:

Terribly reduced optic lobes, isoform AV

Gene

trol

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Terribly reduced optic lobes, isoform AVImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:trolImported
Synonyms:anon-WO0153538.72Imported, BcDNA:GM02481Imported, CG12497Imported, CG33675Imported, CG7981Imported, CT23996Imported, Dmel\CG33950Imported, EG:BACR25B3.1Imported, EG:BACR25B3.10Imported, EG:BACR25B3.11Imported, EG:BACR25B3.2Imported, GC7891Imported, l(1)3AcImported, l(1)9-96Imported, l(1)G0019Imported, l(1)G0021Imported, l(1)G0023Imported, l(1)G0181Imported, l(1)G0211Imported, l(1)G0271Imported, l(1)G0374Imported, l(1)G0412Imported, l(1)trolImported, l(1)VA51Imported, l(1)zw1Imported, l(1)zwlImported, MRE7Imported, PcanImported, pcanImported, PcnImported, TROLImported, TrolImported, Trol-AImported, Trol-BImported, TrollImported, trollImported, ZW-1Imported, zw-1Imported, zw1Imported
ORF Names:CG33950Imported, Dmel_CG33950Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0284408 trol

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi413 ↔ 428PROSITE-ProRule annotation
Disulfide bondi452 ↔ 467PROSITE-ProRule annotation
Disulfide bondi519 ↔ 531PROSITE-ProRule annotation
Disulfide bondi526 ↔ 544PROSITE-ProRule annotation
Disulfide bondi628 ↔ 643PROSITE-ProRule annotation
Disulfide bondi712 ↔ 724PROSITE-ProRule annotation
Disulfide bondi719 ↔ 737PROSITE-ProRule annotation
Disulfide bondi731 ↔ 746PROSITE-ProRule annotation
Disulfide bondi752 ↔ 764PROSITE-ProRule annotation
Disulfide bondi759 ↔ 777PROSITE-ProRule annotation
Disulfide bondi771 ↔ 786PROSITE-ProRule annotation
Disulfide bondi899 ↔ 911PROSITE-ProRule annotation
Disulfide bondi906 ↔ 924PROSITE-ProRule annotation
Disulfide bondi918 ↔ 933PROSITE-ProRule annotation
Disulfide bondi939 ↔ 951PROSITE-ProRule annotation
Disulfide bondi946 ↔ 964PROSITE-ProRule annotation
Disulfide bondi958 ↔ 973PROSITE-ProRule annotation
Disulfide bondi982 ↔ 994PROSITE-ProRule annotation
Disulfide bondi989 ↔ 1007PROSITE-ProRule annotation
Disulfide bondi1001 ↔ 1016PROSITE-ProRule annotation
Disulfide bondi1402 ↔ 1419PROSITE-ProRule annotation
Disulfide bondi1421 ↔ 1430PROSITE-ProRule annotation
Disulfide bondi1472 ↔ 1481PROSITE-ProRule annotation
Disulfide bondi1713 ↔ 1722PROSITE-ProRule annotation
Disulfide bondi1764 ↔ 1773PROSITE-ProRule annotation
Disulfide bondi1832 ↔ 1841PROSITE-ProRule annotation
Disulfide bondi3451 ↔ 3468PROSITE-ProRule annotation
Disulfide bondi3470 ↔ 3479PROSITE-ProRule annotation
Disulfide bondi3486 ↔ 3496PROSITE-ProRule annotation
Disulfide bondi3507 ↔ 3516PROSITE-ProRule annotation
Disulfide bondi3760 ↔ 3769PROSITE-ProRule annotation
Disulfide bondi3931 ↔ 3958PROSITE-ProRule annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0261451 Expressed in arthropod fat body and 24 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
X2JE09 baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
X2JE09

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini795 – 882Ig-likeInterPro annotationAdd BLAST88
Domaini1019 – 1108Ig-likeInterPro annotationAdd BLAST90
Domaini1161 – 1339Laminin IV type AInterPro annotationAdd BLAST179
Domaini1395 – 1450Laminin EGF-likeInterPro annotationAdd BLAST56
Domaini1396 – 1431EGF-likeInterPro annotationAdd BLAST36
Domaini1455 – 1501Laminin EGF-likeInterPro annotationAdd BLAST47
Domaini1529 – 1710Laminin IV type AInterPro annotationAdd BLAST182
Domaini1699 – 1744Laminin EGF-likeInterPro annotationAdd BLAST46
Domaini1745 – 1794Laminin EGF-likeInterPro annotationAdd BLAST50
Domaini1816 – 1861Laminin EGF-likeInterPro annotationAdd BLAST46
Domaini1885 – 2060Laminin IV type AInterPro annotationAdd BLAST176
Domaini2199 – 2290Ig-likeInterPro annotationAdd BLAST92
Domaini2301 – 2383Ig-likeInterPro annotationAdd BLAST83
Domaini2395 – 2486Ig-likeInterPro annotationAdd BLAST92
Domaini2499 – 2581Ig-likeInterPro annotationAdd BLAST83
Domaini2588 – 2675Ig-likeInterPro annotationAdd BLAST88
Domaini2677 – 2764Ig-likeInterPro annotationAdd BLAST88
Domaini2884 – 2968Ig-likeInterPro annotationAdd BLAST85
Domaini2979 – 3065Ig-likeInterPro annotationAdd BLAST87
Domaini3083 – 3176Ig-likeInterPro annotationAdd BLAST94
Domaini3181 – 3263Ig-likeInterPro annotationAdd BLAST83
Domaini3269 – 3446LAM_G_DOMAINInterPro annotationAdd BLAST178
Domaini3442 – 3480EGF-likeInterPro annotationAdd BLAST39
Domaini3482 – 3517EGF-likeInterPro annotationAdd BLAST36
Domaini3526 – 3700LAM_G_DOMAINInterPro annotationAdd BLAST175
Domaini3734 – 3770EGF-likeInterPro annotationAdd BLAST37
Domaini3776 – 3958LAM_G_DOMAINInterPro annotationAdd BLAST183

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni129 – 173DisorderedSequence analysisAdd BLAST45
Regioni465 – 515DisorderedSequence analysisAdd BLAST51
Regioni2767 – 2801DisorderedSequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi475 – 511AcidicSequence analysisAdd BLAST37
Compositional biasi2767 – 2783PolyampholyteSequence analysisAdd BLAST17
Compositional biasi2784 – 2801PolarSequence analysisAdd BLAST18

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, Immunoglobulin domainSAAS annotation, Laminin EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156670

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00112 LDLa, 8 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 13 hits
4.10.400.10, 9 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
IPR002049 Laminin_EGF
IPR001791 Laminin_G
IPR000034 Laminin_IV
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00008 EGF, 1 hit
PF07679 I-set, 3 hits
PF00047 ig, 2 hits
PF13895 Ig_2, 1 hit
PF00052 Laminin_B, 3 hits
PF00053 Laminin_EGF, 7 hits
PF00054 Laminin_G_1, 1 hit
PF02210 Laminin_G_2, 2 hits
PF00057 Ldl_recept_a, 7 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00261 LDLRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 8 hits
SM00180 EGF_Lam, 6 hits
SM00409 IG, 13 hits
SM00408 IGc2, 13 hits
SM00281 LamB, 3 hits
SM00282 LamG, 3 hits
SM00192 LDLa, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 13 hits
SSF49899 SSF49899, 3 hits
SSF57424 SSF57424, 8 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 4 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 4 hits
PS01248 EGF_LAM_1, 4 hits
PS50027 EGF_LAM_2, 5 hits
PS50835 IG_LIKE, 12 hits
PS50025 LAM_G_DOMAIN, 3 hits
PS51115 LAMININ_IVA, 3 hits
PS01209 LDLRA_1, 5 hits
PS50068 LDLRA_2, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 21 potential isoforms that are computationally mapped.Show allAlign All

X2JE09-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMGSPGSQAS AIATSVGIRS GRRGQAGGSL LLRLLAVTFV LAACHAPLLT
60 70 80 90 100
NAKQISNLGD DQDFMLADDE SLQGINDSEW QLMGDDIDDG LLDDVDETLK
110 120 130 140 150
PMETKSEEED LPTGNWFSQS VHRVRRSINR LFGSDDNQER GRRQQRERSQ
160 170 180 190 200
RNRDAINRQK ELRRRQKEDH NRWKQMRMER QLEKQRLVKR TNHVVFNRAT
210 220 230 240 250
DPRKRASDLY DENEASGYHE EDTTLYRTYF VVNEPYDNEY RDRESVQFQN
260 270 280 290 300
LQKLLDDDLR NFFHSNYEGN DDEEQEIRST LERVEIELPT SVNDFGSKLQ
310 320 330 340 350
QQLNVYNRIE NLSAATDGVF SFTESSVTEE SVRHLDVGFV EPHITLFHEQ
360 370 380 390 400
NTGYDDFDRK PTTETQDIEE EAIDVTLPQE EVEGSGSDDS SCRGDATFTC
410 420 430 440 450
PRSGKTICDE MRCDREIQCP DGEDEEYCNY PNVCTEDQFK CDDKCLELKK
460 470 480 490 500
RCDGSIDCLD QTDEAGCINA PEPEPEPEPE PEPEPESEPE AEPEPEPEPE
510 520 530 540 550
PESEPEQEPE PQVPEANECQ ANEFRCNNGD CIDARKRCNN VSDCSEGEDE
560 570 580 590 600
NEECLEGEEE DRVGIPIGHQ PWRPASKHDD WLHEMDTSEY QVYQPSNVYE
610 620 630 640 650
KANSQNPCAS NQFRCTTSNV CIPLHLRCDG FYHCNDMSDE KSCEQYQRHT
660 670 680 690 700
TTRRPLTLAT PTSRITTQGP GLLERRNTTT ATEASRWPWA TKTTTIATTT
710 720 730 740 750
SNPITTVGVA SCYANQFRCN NGDCVSGSAP CNGYSECSDH SDELNCGGTQ
760 770 780 790 800
ECLPNQFRCN SGQCVSSSVR CNGRTDCQDS SDEQNCAADS NDRRPNQLNL
810 820 830 840 850
KTYPDSQIIK ESREVIFRCR DEGPARAKVK WSRPGGRPLP PGFTDRNGRL
860 870 880 890 900
EIPNIRVEDA GTYVCEAVGY ASYIPGQQVT VNLNVERYND VGSRPESACT
910 920 930 940 950
EYQATCMNGE CIDKSSICDG NPDCSDASDE QSCSLGLKCQ PNQFMCSNSK
960 970 980 990 1000
CVDRTWRCDG ENDCGDNSDE TSCDPEPSGA PCRYNEFQCR SGHCIPKSFQ
1010 1020 1030 1040 1050
CDNVPDCTDG TDEVGCMAPL PIRPPPQSVS LLEYEVLELT CVATGTPTPT
1060 1070 1080 1090 1100
IVWRLNWGHV PDKCESKSYG GTGTLRCPDM RPQDSGAYSC EIINTRGTHF
1110 1120 1130 1140 1150
VNPDTIVTVR PVRTDVCEAG FFNMLARKAE ECVQCFCFGV AKACDSANLF
1160 1170 1180 1190 1200
TYAIHPPILS HRVVSVELSP LRQIVINEAA PGQDLLTLLH GVQFRATNVH
1210 1220 1230 1240 1250
FSGRETPYLA LPADYMGNQL KSYGGNLRYE VNYRGSGRPV NGPDVIITGN
1260 1270 1280 1290 1300
RFTLTYRVRT QPGQNNRVSI PFVPGGWQKP DGRKASREEI MMILANVDNI
1310 1320 1330 1340 1350
LIRLGYLDST AREVDLINIA LDSAGTADKG LGSASLVEKC QCPPGYVGDS
1360 1370 1380 1390 1400
CESCASGYVR QPGGPWLGHC VPFIPDSCPS GTYGDPRRGV PCKECPCPLT
1410 1420 1430 1440 1450
GSNNFASGCQ QSPDGDVVCR CNEGYTGRRC EQCAAGYQGN PLAAGGICRR
1460 1470 1480 1490 1500
IPDTSCNVDG TYSVHSNGTC QCKDSVIGEQ CDTCKSKSFH LNSFTYTGCI
1510 1520 1530 1540 1550
ECFCSGVGLD CDSSTWYRDQ VTSTFGRSRV DHGFVLVTNY MQPTPDTVPV
1560 1570 1580 1590 1600
SMAAEPNALS FIGSADQSGN TLYWSLPAAF LGNKLSSYGG KLTYTLSYSP
1610 1620 1630 1640 1650
LPNGIMSRNS APDVVIKSGE DLRLIHYRKS QVVPSVANTY SVEIKESAWQ
1660 1670 1680 1690 1700
RGDEVVANRE HVLMALSDIT AIYIKATYTT STKEASLRQV TLDVATPTNL
1710 1720 1730 1740 1750
GTPRAVEVEQ CRCPEGYLGL SCEQCAPGYA RDPEGGIYLG LCRPCECNGH
1760 1770 1780 1790 1800
SKYCNSDTGD CEECSDNTEG PSCERCAAGY VGDATRGTIY DCQPDEGYPI
1810 1820 1830 1840 1850
PSPPAPGNQT LECTAYCQIE GIYDCRGNEC LCKRNVIGDQ CDQCRPGTYG
1860 1870 1880 1890 1900
LSAQNQDGCK ECYCSGLASQ CRSAALYRQL IPVDFILNAP LITDESGAVQ
1910 1920 1930 1940 1950
DTENLIPDIS RNMYTYTHTS YLPKYWSLRG SVLGNQLFSY GGRLSYSLIV
1960 1970 1980 1990 2000
ESYGNYERGH DIVLIGNGLK LIWSRPDGNE NQEEYNVRLH EDEQWTRQDR
2010 2020 2030 2040 2050
ESARPASRSD FMTVLSDLQH ILIRATPRVP TQSTSIGNVI LESAVTTRTP
2060 2070 2080 2090 2100
GATHASDIEL CQCPSGYVGT SCESCAPLHY RDASGSCSLC PCDVSNTESC
2110 2120 2130 2140 2150
DLVSGGYVEC RCKARWKGDR CREIDTSPII EDPPQICDLS RGFCCSGFQF
2160 2170 2180 2190 2200
DIAPNETISF NDTLQIYKGN RIIGNMTKLR YGCPSRDTND PTDIGTEDPV
2210 2220 2230 2240 2250
LTQIIVSIQK PEITIVPVGG SMTLSCSGRM RWSNSPVIVN WYKENSRLPE
2260 2270 2280 2290 2300
NVEVQGGNLY LYDLQVSDSG VYICQAVNNE TASVFKDTVS ITITKKDQLS
2310 2320 2330 2340 2350
PAEIVNLPSH VTFEEYVNNE IICEVLGNPA PRVTWARVDG HADAQSTRTY
2360 2370 2380 2390 2400
DNRLIFDSPR KSDEGRYRCQ AENDQNRDEK YVIVYVQSNP PQPPPQQDRL
2410 2420 2430 2440 2450
YITPEEINGL AGESFQLNCQ FTSVASLRYD WSHNGRSLSS SPARNVEIRG
2460 2470 2480 2490 2500
NTLEVRDASE SDSGVYTCVA YDVRTRRNFT ESARVNIDRR EEQPFGNKPI
2510 2520 2530 2540 2550
IESLEQNILI IQGEDYSITC EASGSPYPSI KWAKVHDFMP ENVHISGNVL
2560 2570 2580 2590 2600
TIYGARFENR GVYSCVAEND HGSDLSSTSI DIEPRERPSV KIVSAPLQTF
2610 2620 2630 2640 2650
SVGAPASLYC TVEGIPDPTV EWVRVDGQPL SPRHKIQSPG YMVIDDIQLE
2660 2670 2680 2690 2700
DSGDYECRAK NIVGEATGVA TITVQEPTLV QIIPDNRDLR LTEGDELSLT
2710 2720 2730 2740 2750
CVGSGVPNPE VEWVNEMALK RDLYSPPSNT AILKIYRVTK ADAGIYTCHG
2760 2770 2780 2790 2800
KNEAGSDEAH VRVEVQERRG DIGGVDDDSD RDPINYNPPQ QQNPGIHQPG
2810 2820 2830 2840 2850
SNQLLATDIG DNVTLTCDMF QPLNTRWERV DGAPLPRNAY TIKNRLEIVR
2860 2870 2880 2890 2900
VEQQNLGQYR CNGIGRDGNV KTYFVKELVL MPLPRIRFYP NIPLTVEAGQ
2910 2920 2930 2940 2950
NLDVHCQVEN VRPEDVHWST DNNRPLPSSV RIVGSVLRFV SITQAAAGEY
2960 2970 2980 2990 3000
RCSAFNQYGN RSQIARVAVK KPADFHQVPQ SQLQRHREGE NIQLQCTVTD
3010 3020 3030 3040 3050
QYGVRAQDNV EFNWFRDDRR PLPNNARTDS QILVLTNLRP EDAGRYICNS
3060 3070 3080 3090 3100
YDVDRGQQLP EVSIDLQVLT ATPPPNSPIY LPPQLPAKSR DYSLKLDDQS
3110 3120 3130 3140 3150
SNLRAGESTD VECYSSDDTY TDVVWERSDG APLSNNVRQV GNRLVISNVS
3160 3170 3180 3190 3200
PSDAGNYVCK CKTDEGDLYT TSYKLEVEDQ PHELKSSKIV YAKVGANADL
3210 3220 3230 3240 3250
QCGADESRQP TYRWSRQYGQ LQAGRSLMNE KLSLDSVQAN DAGTYICTAQ
3260 3270 3280 3290 3300
YADGETADFP NILVVTGAIP QFRQEPRSYM SFPTLPNSSF KFNFELTFRP
3310 3320 3330 3340 3350
ENGDGLLLFN GQTRGSGDYI ALSLKDRYAE FRFDFGGKPM LVRAEEPLAL
3360 3370 3380 3390 3400
NEWHTVRVSR FKRDGYIQVD EQHPVAFPTL QQIPQLDLIE DLYIGGVPNW
3410 3420 3430 3440 3450
ELLPADAVSQ QVGFVGCISR LTLQGRTVEL IREAKYKEGI TDCRPCAQGP
3460 3470 3480 3490 3500
CQNKGVCLES QTEQAYTCIC QPGWTGRDCA IEGTQCTPGV CGAGRCENTE
3510 3520 3530 3540 3550
NDMECLCPLN RSGDRCQYNE ILNEHSLNFK GNSFAAYGTP KVTKVNITLS
3560 3570 3580 3590 3600
VRPASLEDSV ILYTAESTLP SGDYLALVLR GGHAELLINT AARLDPVVVR
3610 3620 3630 3640 3650
SAEPLPLNRW TRIEIRRRLG EGILRVGDGP ERKAKAPGSD RILSLKTHLY
3660 3670 3680 3690 3700
VGGYDRSTVK VNRDVNITKG FDGCISRLYN FQKPVNLLAD IKDAANIQSC
3710 3720 3730 3740 3750
GETNMIGGDE DSDNEPPVPP PTPDVHENEL QPYAMAPCAS DPCENGGSCS
3760 3770 3780 3790 3800
EQEDVAVCSC PFGFSGKHCQ EHLQLGFNAS FRGDGYVELN RSHFQPALEQ
3810 3820 3830 3840 3850
SYTSMGIVFT TNKPNGLLFW WGQEAGEEYT GQDFIAAAVV DGYVEYSMRL
3860 3870 3880 3890 3900
DGEEAVIRNS DIRVDNGERH IVIAKRDENT AILEVDRMLH SGETRPTSKK
3910 3920 3930 3940 3950
SMKLPGNVFV GGAPDLEVFT GFRYKHNLNG CIVVVEGETV GQINLSSAAV
3960 3970
NGVNANVCPA NDDPLGGTEP PVV
Length:3,973
Mass (Da):440,385
Last modified:June 11, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6608CC4F7E925EDA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 21 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9W4Y3Q9W4Y3_DROME
Terribly reduced optic lobes, isofo...
trol anon-WO0153538.72, BcDNA:GM02481, CG12497, CG33675, CG7981
4,479Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9NE56M9NE56_DROME
Terribly reduced optic lobes, isofo...
trol anon-WO0153538.72, BcDNA:GM02481, CG12497, CG33675, CG7981
4,176Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9NET2M9NET2_DROME
Terribly reduced optic lobes, isofo...
trol anon-WO0153538.72, BcDNA:GM02481, CG12497, CG33675, CG7981
3,897Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8IRV7Q8IRV7_DROME
Terribly reduced optic lobes, isofo...
trol anon-WO0153538.72, BcDNA:GM02481, CG12497, CG33675, CG7981
3,105Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8IRV8Q8IRV8_DROME
Terribly reduced optic lobes, isofo...
trol anon-WO0153538.72, BcDNA:GM02481, CG12497, CG33675, CG7981
3,887Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8IRV9Q8IRV9_DROME
Terribly reduced optic lobes, isofo...
trol anon-WO0153538.72, BcDNA:GM02481, CG12497, CG33675, CG7981
4,007Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8MPN3Q8MPN3_DROME
Perlecan
trol anon-WO0153538.72, BcDNA:GM02481, CG12497, CG33675, CG7981
4,223Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q9W4Y4Q9W4Y4_DROME
Terribly reduced optic lobes, isofo...
trol anon-WO0153538.72, BcDNA:GM02481, CG12497, CG33675, CG7981
4,150Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E1JJC0E1JJC0_DROME
Terribly reduced optic lobes, isofo...
trol anon-WO0153538.72, BcDNA:GM02481, CG12497, CG33675, CG7981
4,411Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X2JAC7X2JAC7_DROME
Terribly reduced optic lobes, isofo...
trol anon-WO0153538.72, BcDNA:GM02481, CG12497, CG33675, CG7981
2,853Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AHN59294.1

NCBI Reference Sequences

More...
RefSeqi
NP_001284823.1, NM_001297894.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0342821; FBpp0309657; FBgn0284408

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
45320

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AHN59294.1
RefSeqiNP_001284823.1, NM_001297894.1

3D structure databases

SMRiX2JE09
ModBaseiSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0342821; FBpp0309657; FBgn0284408
GeneIDi45320

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
45320
FlyBaseiFBgn0284408 trol

Phylogenomic databases

GeneTreeiENSGT00940000156670

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
trol fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
45320

Gene expression databases

BgeeiFBgn0261451 Expressed in arthropod fat body and 24 other tissues
ExpressionAtlasiX2JE09 baseline and differential

Family and domain databases

CDDicd00112 LDLa, 8 hits
Gene3Di2.60.40.10, 13 hits
4.10.400.10, 9 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
IPR002049 Laminin_EGF
IPR001791 Laminin_G
IPR000034 Laminin_IV
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
PfamiView protein in Pfam
PF00008 EGF, 1 hit
PF07679 I-set, 3 hits
PF00047 ig, 2 hits
PF13895 Ig_2, 1 hit
PF00052 Laminin_B, 3 hits
PF00053 Laminin_EGF, 7 hits
PF00054 Laminin_G_1, 1 hit
PF02210 Laminin_G_2, 2 hits
PF00057 Ldl_recept_a, 7 hits
PRINTSiPR00261 LDLRECEPTOR
SMARTiView protein in SMART
SM00181 EGF, 8 hits
SM00180 EGF_Lam, 6 hits
SM00409 IG, 13 hits
SM00408 IGc2, 13 hits
SM00281 LamB, 3 hits
SM00282 LamG, 3 hits
SM00192 LDLa, 9 hits
SUPFAMiSSF48726 SSF48726, 13 hits
SSF49899 SSF49899, 3 hits
SSF57424 SSF57424, 8 hits
PROSITEiView protein in PROSITE
PS00022 EGF_1, 4 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 4 hits
PS01248 EGF_LAM_1, 4 hits
PS50027 EGF_LAM_2, 5 hits
PS50835 IG_LIKE, 12 hits
PS50025 LAM_G_DOMAIN, 3 hits
PS51115 LAMININ_IVA, 3 hits
PS01209 LDLRA_1, 5 hits
PS50068 LDLRA_2, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiX2JE09_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: X2JE09
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 11, 2014
Last sequence update: June 11, 2014
Last modified: February 26, 2020
This is version 54 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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