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Protein
Submitted name:

Eukaryotic translation initiation factor 4H1, isoform D

Gene

eIF4H1

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factorImported, RNA-bindingPROSITE-ProRule annotation
Biological processProtein biosynthesis

Enzyme and pathway databases

ReactomeiR-DME-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-DME-72649 Translation initiation complex formation
R-DME-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
R-DME-72702 Ribosomal scanning and start codon recognition
R-DME-72706 GTP hydrolysis and joining of the 60S ribosomal subunit

Names & Taxonomyi

Protein namesi
Submitted name:
Eukaryotic translation initiation factor 4H1, isoform DImported
Gene namesi
Name:eIF4H1Imported
Synonyms:anon-EST:fe1B9Imported, CG4429Imported, cg4429Imported, Dmel\CG4429Imported, eIF4HImported, MRE9Imported, Rbp2Imported, RNA-binding protein 2Imported, RRM2Imported, rrm2Imported
ORF Names:CG4429Imported, Dmel_CG4429Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0262734 eIF4H1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiX2JC79

Expressioni

Gene expression databases

BgeeiFBgn0262734 Expressed in 28 organ(s), highest expression level in wing disc (Drosophila)
ExpressionAtlasiX2JC79 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliX2JC79
SMRiX2JC79
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 108RRMInterPro annotationAdd BLAST80

Phylogenomic databases

GeneTreeiENSGT00530000063406
OrthoDBiEOG091G0PIF

Family and domain databases

CDDicd12401 RRM_eIF4H, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR034229 eIF4H_RRM
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.iShow all

X2JC79-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGRGGYEHA RSGFGGDRAS KQLPTEPPFI AFVGNLPQGL VQGDVIKIFQ
60 70 80 90 100
DFEVKYVRLV KDRETDQFKG FCYVEFETLD NLERALECDG RIKLDDLSAP
110 120 130 140 150
LRIDIADRRK NDRPGGGVGG GNGGMTRGDG GRDGFQKRGP PRQGGSSQSY
160 170 180 190 200
SRGGPGTGGG GREGGGGSGN RGDSRGSYID SYGGHNDRSR GVGGSGAGSG
210 220 230 240 250
GGMNRGYNDR PANRGRYGSF NNDDRPFERN QDRDRGQREG SYGNQSRDGD
260 270 280 290 300
RYNNFNRHRD RERTHYNPNQ QSERPSGGMT GLGGGSGGSG GLGVGGGSSM
310 320 330 340 350
GAIDNFRHFK KPISRIISNM CQSRVSQLAV PRTNDNERPR LQLKPRTIAA
360 370 380
PINAVAETKQ SASIFGNAKP REEKLKELQQ NVNHNGDN
Length:388
Mass (Da):41,775
Last modified:June 11, 2014 - v1
Checksum:i507B179E24B88801
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9VXF8Q9VXF8_DROME
Eukaryotic translation initiation f...
eIF4H1 anon-EST:fe1B9, CG4429, cg4429, Dmel\CG4429, eIF4H eIF4H1 anon-EST:fe1B9, CG4429, cg4429, Dmel\CG4429, eIF4H, MRE9, Rbp2, RNA-binding protein 2, RRM2, rrm2, CG4429, Dmel_CG4429
325Annotation score:
Q8IR13Q8IR13_DROME
Eukaryotic translation initiation f...
eIF4H1 anon-EST:fe1B9, CG4429, cg4429, Dmel\CG4429, eIF4H eIF4H1 anon-EST:fe1B9, CG4429, cg4429, Dmel\CG4429, eIF4H, MRE9, Rbp2, RNA-binding protein 2, RRM2, rrm2, CG4429, Dmel_CG4429
324Annotation score:
X2JE34X2JE34_DROME
Eukaryotic translation initiation f...
eIF4H1 anon-EST:fe1B9, CG4429, cg4429, Dmel\CG4429, eIF4H eIF4H1 anon-EST:fe1B9, CG4429, cg4429, Dmel\CG4429, eIF4H, MRE9, Rbp2, RNA-binding protein 2, RRM2, rrm2, CG4429, Dmel_CG4429
317Annotation score:
Q7KUX7Q7KUX7_DROME
Eukaryotic translation initiation f...
eIF4H1 anon-EST:fe1B9, cg4429, Dmel\CG4429, eIF4H, MRE9 eIF4H1 anon-EST:fe1B9, cg4429, Dmel\CG4429, eIF4H, MRE9, Rbp2, Rbp2-RC, RNA-binding protein 2, RRM2, rrm2, CG4429, Dmel_CG4429
358Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AHN59800.1
RefSeqiNP_001285330.1, NM_001298401.1
UniGeneiDm.18619

Genome annotation databases

EnsemblMetazoaiFBtr0343632; FBpp0310225; FBgn0262734
GeneIDi49809
KEGGidme:Dmel_CG4429

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AHN59800.1
RefSeqiNP_001285330.1, NM_001298401.1
UniGeneiDm.18619

3D structure databases

ProteinModelPortaliX2JC79
SMRiX2JC79
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiX2JC79

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0343632; FBpp0310225; FBgn0262734
GeneIDi49809
KEGGidme:Dmel_CG4429

Organism-specific databases

CTDi49809
FlyBaseiFBgn0262734 eIF4H1

Phylogenomic databases

GeneTreeiENSGT00530000063406
OrthoDBiEOG091G0PIF

Enzyme and pathway databases

ReactomeiR-DME-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-DME-72649 Translation initiation complex formation
R-DME-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
R-DME-72702 Ribosomal scanning and start codon recognition
R-DME-72706 GTP hydrolysis and joining of the 60S ribosomal subunit

Miscellaneous databases

ChiTaRSiRbp2 fly
GenomeRNAii49809

Gene expression databases

BgeeiFBgn0262734 Expressed in 28 organ(s), highest expression level in wing disc (Drosophila)
ExpressionAtlasiX2JC79 baseline and differential

Family and domain databases

CDDicd12401 RRM_eIF4H, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR034229 eIF4H_RRM
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiX2JC79_DROME
AccessioniPrimary (citable) accession number: X2JC79
Entry historyiIntegrated into UniProtKB/TrEMBL: June 11, 2014
Last sequence update: June 11, 2014
Last modified: September 12, 2018
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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