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Entry version 47 (08 May 2019)
Sequence version 1 (11 Jun 2014)
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Protein

Protein nervous wreck

Gene

nwk

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein that provides a link between vesicular membrane traffic and the actin assembly machinery. Acts together with Cdc42 to stimulate actin nucleation mediated by WASp and the ARP2/3 complex (PubMed:18701694, PubMed:27601635). Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and causes local membrane deformation (PubMed:23761074, PubMed:26686642). Required for normal structure and function of synapses at the neuromuscular junction (PubMed:18701694, PubMed:14980202, PubMed:18498733, PubMed:21464232, PubMed:26686642, PubMed:26567222, PubMed:27601635, PubMed:29568072). Plays a role in synaptic vesicle trafficking (PubMed:29568072). Required for the release of a normal number of synaptic vesicles per action potential (PubMed:26567222).9 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandLipid-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein nervous wreck3 Publications
Short name:
Nwk1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nwkImported
ORF Names:CG43479Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0263456 nwk

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasmic vesicle, Endosome, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

No visible phenotype in adults at room temperature, but flies rapidly loose coordination and become paralyzed within three minutes at 38 degrees Celsius (PubMed:14980202). Larvae display overgrowth of neuromuscular junctions, with increased numbers of synaptic boutons and increased frequency and complexity of axon branching (PubMed:14980202, PubMed:18701694, PubMed:18498733, PubMed:21464232, PubMed:26686642, PubMed:29568072). The synaptic area and the number of reserve and readily releasable synaptic vesicles are decreased (PubMed:29568072).6 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi676E → R: Decreased interaction with F-BAR domain. No effect on interaction with Dap160. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004462751 – 1075Protein nervous wreckAdd BLAST1075

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in larval body wall muscle (PubMed:29568072). Detected at the neuromuscular junction, on motoneuron axons and axon terminals, at synaptic boutons in the periactive zone surrounding the synapse (at protein level) (PubMed:14980202, PubMed:29568072). Detected on motoneuron axons and axon terminals, at synaptic boutons in the periactive zone surrounding the synapse (PubMed:26686642).3 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detected in embryonic brain, ventral nerve cord and sensory neurons, but not in muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
FBgn0263456 Expressed in 24 organ(s), highest expression level in brain

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
X2JAU8 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (Probable) (PubMed:27601635). Interacts (via SH3 domain 1) with WASp (PubMed:14980202, PubMed:18701694, PubMed:27601635). Interacts (via SH3 domain 1) with shi/dynamin (PubMed:18701694, PubMed:18498733). Interacts (via SH3 domain 2) with Dap160 (PubMed:18701694, PubMed:18498733, PubMed:26686642). Interacts (via F-BAR domain) with SH3PX1 (PubMed:26567222). Interacts (via SH3 domain 2) with Snx16 (PubMed:21464232). Identified in a complex with Syn and Syt1 (PubMed:29568072).1 Publication8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
WASpQ9VAT03EBI-167691,EBI-132019

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
X2JAU8, 1 interactor

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0301205

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
X2JAU8

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini11 – 289F-BARPROSITE-ProRule annotationAdd BLAST279
Domaini542 – 603SH3 1PROSITE-ProRule annotationAdd BLAST62
Domaini658 – 721SH3 2PROSITE-ProRule annotationAdd BLAST64

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

In the autoinhibited state, the SH3 domains are bound to the concave surface of the F-BAR domain and prevent promiscuous membrane binding.2 Publications
Upon heterologous expression, the isolated F-BAR domain is localized at the cell membrane, and causes the formation of cellular protrusions (PubMed:23761074, PubMed:26686642). Contrary to F-BAR domains from other proteins, causes membrane flattening on giant unilamellar vesicles (in vitro) (PubMed:23761074, PubMed:26686642). Binds to membranes enriched in phosphatidylserine and phosphatidylinositides, such as phosphatidylinositol 3-phosphate, phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate (PubMed:23761074, PubMed:26686642, PubMed:27601635).3 Publications

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410INNZ Eukaryota
ENOG410XSX6 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00510000046732

Identification of Orthologs from Complete Genome Data

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OMAi
DGMEERW

Database of Orthologous Groups

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OrthoDBi
EOG091G02AL

Family and domain databases

Conserved Domains Database

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CDDi
cd11761 SH3_FCHSD_1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.1270.60, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR001060 FCH_dom
IPR035460 FCHSD_SH3_1
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

Pfam protein domain database

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Pfami
View protein in Pfam
PF00611 FCH, 1 hit
PF00018 SH3_1, 2 hits

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00452 SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00055 FCH, 1 hit
SM00326 SH3, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF103657 SSF103657, 1 hit
SSF50044 SSF50044, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51741 F_BAR, 1 hit
PS50002 SH3, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (9)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 9 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: X2JAU8-1) [UniParc]FASTAAdd to basket
Also known as: I

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQPPPRKGNY VKFLKNLHTE QVAKLQLKNQ HECDLLEDIR QFTIKRSAVE
60 70 80 90 100
KSYSESLLKI SSQYLNKKIP NIPDIKMEGM EERWNMWSVW RTVLEENEKL
110 120 130 140 150
ARARLAAIEV FQQQIADEAK VLRDYKLAIA KRSLAGIVNV QKELHLSVGD
160 170 180 190 200
VDKTKKSYFD EEHCAHDVRD KARDIEEKLK KKKGSFFQSI TSLQKNSARV
210 220 230 240 250
TSRKELLEEK SSGARNDYVL SLAAANAHQN RYFTVDLQTT MTTMENYVFE
260 270 280 290 300
RVAEYLMLMG RTELLTCSAT QNSFGKIRDQ AQQLTREYNL QCCYLFYPVL
310 320 330 340 350
KQHIQYDFEA CDNDPVRKVT AEHESAAETL TKEAKNLAGR VVKENASIRE
360 370 380 390 400
NAKKLALCQS LRDSGQRTDP NDPNGPDLDT KIEEFRDQIR RSETEKTKAE
410 420 430 440 450
ACLQCLRDGG INVDEWVQEA ENMGVQELTR SASSISMRTD ASGQGENPSS
460 470 480 490 500
DSFYDSDKEE TQAAAQTKPK QEQQLSRDRT FSDSEDEPEV RPSAAAASSA
510 520 530 540 550
AAASSSMMAS SAGGWDDPTE VNWGAGEEED DKDEPIVPEP KEAIFKCTAL
560 570 580 590 600
YSYTAQNPDE LTIVENEQLE VVGEGDGDGW LRARNYRGEE GYVPHNYLDI
610 620 630 640 650
DQETAGSAFN GTSGNQLRSQ ISFSSVDYTV DNEDQTVDSM QSPDQVSVIM
660 670 680 690 700
APQKRVKSDV EWCIALYDYD ATAEDELTFE EGDKIKIITK TAHGVDDGWW
710 720 730 740 750
EGELDGKFGN FPSLVVEECD EMGEPLSEGG DESPPPTAAP TFALPPAPAL
760 770 780 790 800
PPEYAHELEL ELTEDMFGSQ DTADEDSGYI PNGAAAPSIP PPVLIQEPGM
810 820 830 840 850
EDDLSDDGQP PPSLPPPQLA KAGGSAPGSG SKVEKGAAAG GANTLNLGMA
860 870 880 890 900
QIIVTAATPM VEDGADKSFP PVGESDAQPV EPVSKEQPAE VAKKPDIAPK
910 920 930 940 950
PLAKVAPQSA PAKEGNAGVR PVVSITLTEY PSCDAEDQQS FSEGTDSASV
960 970 980 990 1000
ADVPVLQDAE DPFNEKAKGE SGDGSGFEAN FEANFDANFD DAFAGIGGGG
1010 1020 1030 1040 1050
GGGGGGGEQS NELDINGEAA GEAIVSGSAA GDEDIEAPKQ VVGGRASIPE
1060 1070
ELDSNQLAHY HEHEIYYVDY SHGQL
Length:1,075
Mass (Da):117,255
Last modified:June 11, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA3AC3F8BE5A890FC
GO
Isoform 2 (identifier: X2JAU8-2) [UniParc]FASTAAdd to basket
Also known as: D, G

The sequence of this isoform differs from the canonical sequence as follows:
     1059-1075: HYHEHEIYYVDYSHGQL → RLQNLKESNA

Show »
Length:1,068
Mass (Da):116,237
Checksum:iDE874B587D6FE903
GO
Isoform 3 (identifier: X2JAU8-3) [UniParc]FASTAAdd to basket
Also known as: H

The sequence of this isoform differs from the canonical sequence as follows:
     611-633: Missing.
     848-872: Missing.
     915-935: Missing.

Show »
Length:1,006
Mass (Da):110,109
Checksum:i871FFCEB1DF6402D
GO
Isoform 4 (identifier: X2JAU8-4) [UniParc]FASTAAdd to basket
Also known as: L

The sequence of this isoform differs from the canonical sequence as follows:
     611-633: Missing.
     915-935: Missing.

Show »
Length:1,031
Mass (Da):112,637
Checksum:i862629D8AA05D5AA
GO
Isoform 5 (identifier: X2JAU8-5) [UniParc]FASTAAdd to basket
Also known as: K

The sequence of this isoform differs from the canonical sequence as follows:
     774-792: Missing.
     1059-1075: HYHEHEIYYVDYSHGQL → RLQNLKESNA

Show »
Length:1,049
Mass (Da):114,387
Checksum:iD6AB88A74C4A2810
GO
Isoform 6 (identifier: X2JAU8-6) [UniParc]FASTAAdd to basket
Also known as: J

The sequence of this isoform differs from the canonical sequence as follows:
     774-792: Missing.

Show »
Length:1,056
Mass (Da):115,405
Checksum:i9E5A7F37646D3924
GO
Isoform 7 (identifier: X2JAU8-7) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     611-633: Missing.
     848-871: Missing.
     915-935: Missing.
     1059-1075: HYHEHEIYYVDYSHGQL → RLQNLKESNA

Show »
Length:1,000
Mass (Da):109,190
Checksum:i9CB439DF12FC15BF
GO
Isoform 8 (identifier: X2JAU8-8) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     793-1074: VLIQEPGMED...IYYVDYSHGQ → GKCHILALSTGLLFPLSISLFKLYPYRF

Show »
Length:821
Mass (Da):91,958
Checksum:iFCB7C6881B9F8926
GO
Isoform 9 (identifier: X2JAU8-9) [UniParc]FASTAAdd to basket
Also known as: F

The sequence of this isoform differs from the canonical sequence as follows:
     793-885: VLIQEPGMED...DAQPVEPVSK → GQNQSQTTAK...TCLQLFPKDI
     886-1075: Missing.

Show »
Length:885
Mass (Da):99,425
Checksum:i64BA4FCEA13B445D
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_060051611 – 633Missing in isoform 3, isoform 4 and isoform 7. Add BLAST23
Alternative sequenceiVSP_060052774 – 792Missing in isoform 5 and isoform 6. Add BLAST19
Alternative sequenceiVSP_060053793 – 1074VLIQE…YSHGQ → GKCHILALSTGLLFPLSISL FKLYPYRF in isoform 8. Add BLAST282
Alternative sequenceiVSP_060054793 – 885VLIQE…EPVSK → GQNQSQTTAKKGNLMNMLFY LNYLIPETFPDSVILSVGKS ISTPLFESMSNPPLNYCSTF KMRFSSWYIEKNIQYIFSIR FLSTCLQLFPKDI in isoform 9. Add BLAST93
Alternative sequenceiVSP_060055848 – 872Missing in isoform 3. Add BLAST25
Alternative sequenceiVSP_060056848 – 871Missing in isoform 7. Add BLAST24
Alternative sequenceiVSP_060057886 – 1075Missing in isoform 9. Add BLAST190
Alternative sequenceiVSP_060058915 – 935Missing in isoform 3, isoform 4 and isoform 7. Add BLAST21
Alternative sequenceiVSP_0600591059 – 1075HYHEH…SHGQL → RLQNLKESNA in isoform 2, isoform 5 and isoform 7. Add BLAST17

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AE014296 Genomic DNA Translation: AFH04360.1
AE014296 Genomic DNA Translation: AFH04361.1
AE014296 Genomic DNA Translation: AFH04362.1
AE014296 Genomic DNA Translation: AFH04363.1
AE014296 Genomic DNA Translation: AAF50313.4
AE014296 Genomic DNA Translation: AHN58018.1
AE014296 Genomic DNA Translation: AHN58019.1
AE014296 Genomic DNA Translation: AHN58020.1
AE014296 Genomic DNA Translation: AHN58021.1
AE014296 Genomic DNA Translation: AHN58022.1

NCBI Reference Sequences

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RefSeqi
NP_001246689.1, NM_001259760.2 [X2JAU8-7]
NP_001246690.1, NM_001259761.2 [X2JAU8-8]
NP_001246691.1, NM_001259762.2 [X2JAU8-2]
NP_001246692.1, NM_001259763.2 [X2JAU8-9]
NP_001286993.1, NM_001300064.1 [X2JAU8-3]
NP_001286994.1, NM_001300065.1 [X2JAU8-1]
NP_001286995.1, NM_001300066.1 [X2JAU8-6]
NP_001286996.1, NM_001300067.1 [X2JAU8-5]
NP_001286997.1, NM_001300068.1 [X2JAU8-4]
NP_648290.3, NM_140033.3 [X2JAU8-2]

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0309276; FBpp0301203; FBgn0263456 [X2JAU8-7]
FBtr0309277; FBpp0301204; FBgn0263456 [X2JAU8-8]
FBtr0309278; FBpp0301205; FBgn0263456 [X2JAU8-2]
FBtr0309280; FBpp0301207; FBgn0263456 [X2JAU8-9]
FBtr0331857; FBpp0304241; FBgn0263456 [X2JAU8-2]
FBtr0344238; FBpp0310642; FBgn0263456 [X2JAU8-3]
FBtr0344239; FBpp0310643; FBgn0263456 [X2JAU8-1]
FBtr0344240; FBpp0310644; FBgn0263456 [X2JAU8-6]
FBtr0344241; FBpp0310645; FBgn0263456 [X2JAU8-5]
FBtr0344242; FBpp0310646; FBgn0263456 [X2JAU8-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
39052

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AFH04360.1
AE014296 Genomic DNA Translation: AFH04361.1
AE014296 Genomic DNA Translation: AFH04362.1
AE014296 Genomic DNA Translation: AFH04363.1
AE014296 Genomic DNA Translation: AAF50313.4
AE014296 Genomic DNA Translation: AHN58018.1
AE014296 Genomic DNA Translation: AHN58019.1
AE014296 Genomic DNA Translation: AHN58020.1
AE014296 Genomic DNA Translation: AHN58021.1
AE014296 Genomic DNA Translation: AHN58022.1
RefSeqiNP_001246689.1, NM_001259760.2 [X2JAU8-7]
NP_001246690.1, NM_001259761.2 [X2JAU8-8]
NP_001246691.1, NM_001259762.2 [X2JAU8-2]
NP_001246692.1, NM_001259763.2 [X2JAU8-9]
NP_001286993.1, NM_001300064.1 [X2JAU8-3]
NP_001286994.1, NM_001300065.1 [X2JAU8-1]
NP_001286995.1, NM_001300066.1 [X2JAU8-6]
NP_001286996.1, NM_001300067.1 [X2JAU8-5]
NP_001286997.1, NM_001300068.1 [X2JAU8-4]
NP_648290.3, NM_140033.3 [X2JAU8-2]

3D structure databases

SMRiX2JAU8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiX2JAU8, 1 interactor
STRINGi7227.FBpp0301205

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0309276; FBpp0301203; FBgn0263456 [X2JAU8-7]
FBtr0309277; FBpp0301204; FBgn0263456 [X2JAU8-8]
FBtr0309278; FBpp0301205; FBgn0263456 [X2JAU8-2]
FBtr0309280; FBpp0301207; FBgn0263456 [X2JAU8-9]
FBtr0331857; FBpp0304241; FBgn0263456 [X2JAU8-2]
FBtr0344238; FBpp0310642; FBgn0263456 [X2JAU8-3]
FBtr0344239; FBpp0310643; FBgn0263456 [X2JAU8-1]
FBtr0344240; FBpp0310644; FBgn0263456 [X2JAU8-6]
FBtr0344241; FBpp0310645; FBgn0263456 [X2JAU8-5]
FBtr0344242; FBpp0310646; FBgn0263456 [X2JAU8-4]
GeneIDi39052

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
39052
FlyBaseiFBgn0263456 nwk

Phylogenomic databases

eggNOGiENOG410INNZ Eukaryota
ENOG410XSX6 LUCA
GeneTreeiENSGT00510000046732
OMAiDGMEERW
OrthoDBiEOG091G02AL

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
39052

Gene expression databases

BgeeiFBgn0263456 Expressed in 24 organ(s), highest expression level in brain
ExpressionAtlasiX2JAU8 baseline and differential

Family and domain databases

CDDicd11761 SH3_FCHSD_1, 1 hit
Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR001060 FCH_dom
IPR035460 FCHSD_SH3_1
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00611 FCH, 1 hit
PF00018 SH3_1, 2 hits
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00055 FCH, 1 hit
SM00326 SH3, 2 hits
SUPFAMiSSF103657 SSF103657, 1 hit
SSF50044 SSF50044, 2 hits
PROSITEiView protein in PROSITE
PS51741 F_BAR, 1 hit
PS50002 SH3, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNWK_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: X2JAU8
Secondary accession number(s): M9NE66
, M9NF56, M9NFQ1, Q9VSU8, X2J8V0, X2JC77, X2JCQ1, X2JGF9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 13, 2019
Last sequence update: June 11, 2014
Last modified: May 8, 2019
This is version 47 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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