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UniProtKB - X2J8G9 (X2J8G9_DROME)

Entry version 61 (19 Jan 2022)
Sequence version 1 (11 Jun 2014)
Previous versions | rss
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Protein
Submitted name:

Klarsicht, isoform H

Gene

klar

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Klarsicht, isoform HImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:klarImported
Synonyms:Dmel\CG17046Imported, KlarImported, klsImported, marbImported
ORF Names:CG17046Imported, Dmel_CG17046Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0001316, klar

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		VectorBase:FBgn0001316

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		X2J8G9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0001316, Expressed in wing disc (Drosophila) and 40 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		X2J8G9, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni46 – 67DisorderedSequence analysisAdd BLAST22
Regioni174 – 205DisorderedSequence analysisAdd BLAST32
Regioni234 – 272DisorderedSequence analysisAdd BLAST39
Regioni374 – 405DisorderedSequence analysisAdd BLAST32
Regioni490 – 531DisorderedSequence analysisAdd BLAST42
Regioni620 – 690DisorderedSequence analysisAdd BLAST71
Regioni910 – 936DisorderedSequence analysisAdd BLAST27
Regioni968 – 1044DisorderedSequence analysisAdd BLAST77

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi174 – 196Polar residuesSequence analysisAdd BLAST23
Compositional biasi382 – 405Polar residuesSequence analysisAdd BLAST24
Compositional biasi640 – 656Polar residuesSequence analysisAdd BLAST17
Compositional biasi660 – 675Basic residuesSequence analysisAdd BLAST16
Compositional biasi917 – 936Polar residuesSequence analysisAdd BLAST20
Compositional biasi987 – 1011Basic and acidic residuesSequence analysisAdd BLAST25
Compositional biasi1030 – 1044Basic and acidic residuesSequence analysisAdd BLAST15

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_271182_0_0_1

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039906, Anc-1-like

The PANTHER Classification System

More...PANTHERi		PTHR21524, PTHR21524, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

X2J8G9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPQSSNSNIS SSNSLLQQRN HNIGNKMLPN KAHGKNIAVA VITPNSHGNT 
        60         70         80         90        100
SHGHGLGHGL GHELNKSPLG LRKTRHHHND TSKFNRSNRK SKNCAIFYFK 
       110        120        130        140        150
HLDTDNEQGN AAGSDLQSED DPSLIHRRRA GGDILKSADA STDDDDEGWL 
       160        170        180        190        200
YTATAAATLE VATAATAAPT AAAATSSVDG LQSTAVSSTT ATGGPLPPSD 
       210        220        230        240        250
DSDKENKVAL VSATTITAAA TATATSIATL HSSNYDSSSA CSSSNSNSNS 
       260        270        280        290        300
NSNSNGRLTE TSATSRVTQL QMQIHSQSQS QSQMELQING NAIDGRHIIS 
       310        320        330        340        350
NNNCYSSMQH QPQNNNEGEA AEDLAKIKMG DDEAAADMAN GNATKSQQMS 
       360        370        380        390        400
NGVYSRADSC NFTVWAAETV ASCHLPPRSP AKSAKSSKSQ ASNATVSGST 
       410        420        430        440        450
LVSPVKGKVS HDSIKQLVLE AEHLVRDAQE TALKTPTKQK HSIIKISSTV 
       460        470        480        490        500
KKREVTMPHP IKQRVEEWLE HQPSTPQLLT RSHTHELLPS CKPDDCEASG 
       510        520        530        540        550
EASETDSVPQ AGAGVNGGAP NGAGSDTSEG FTDSIATCMQ TSTNSYGNST 
       560        570        580        590        600
ERIGGSAEPI GQPVTPLGFG SSNQSLNVKI VKRSQTRRKS ERPWSVSCLS 
       610        620        630        640        650
QLTTDAAQLT TARIVENSPS GLASHSISES ALDSLSPGPR PRAASSSGTG 
       660        670        680        690        700
SNAAKKADSK GSLRRRKARK KRISAASAGR KSDSGSELGG DLTQTLMKSC 
       710        720        730        740        750
ESMSSQQLQE FTNALLSIQK GAVVAPLSPK GDVSGVPSLA DGEGGETQLM 
       760        770        780        790        800
LPKFRVGSFT TAGLLATDTR LGALAALSNY MNEDEQQAEL STEDHHSSIS 
       810        820        830        840        850
ETAWDNYQEK YNSENYSEGF DSDAARRLLE FGDDYRNFID SQSDCCSSLS 
       860        870        880        890        900
AANNLDSFSP PRMDSLQKHE LKTLHINQDT ITSTVDHARR QRALELQYER 
       910        920        930        940        950
RRKTLEVRRK SCQDMDESLM ASPQSDQQQQ QLQVTPSLSA SATALMTTPK 
       960        970        980        990       1000
IQSTSHQISH RAESVGRKLD FGGMSHSAQS LLRRTSESDT STRRRRTVTA 
      1010       1020       1030       1040       1050
DERRRSSRNL EKCIKLIPAT TSSSSGSDSE DGEQEMRSLL QQSRDRLDDT 
      1060       1070       1080       1090       1100
RALKIRCHLL RPEDYNEIIN TCRDNIRCLE AVLRGPPGTV LSNHCAGQTK 
      1110       1120       1130       1140       1150
VSACLRRRRR RRLGTELPGP TESGDSRQMV HMVECQCAPI TRFVARVIEF 
      1160       1170       1180       1190 
VLDVGNMLEH FALYRFLAGT LRSLYELVDR PVGGRLGRFF DGLRGLF
Length:1,197
Mass (Da):129,095
Last modified:June 11, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5ED2E0478943B7E2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9Y0E4KLAR_DROME
Klarsicht protein
klar CG17046
2,262Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8JNH1A8JNH1_DROME
GM19713p
klar Dmel\CG17046, Klar, klar-RC, kls, marb
567Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q9W0Q4Q9W0Q4_DROME
Klarsicht, isoform A
klar Dmel\CG17046, Klar, kls, marb, CG17046
2,262Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PGK7M9PGK7_DROME
Klarsicht, isoform E
klar Dmel\CG17046, Klar, kls, marb, CG17046
2,272Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X2JAH4X2JAH4_DROME
Klarsicht, isoform I
klar Dmel\CG17046, Klar, kls, marb, CG17046
511Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q7YU15Q7YU15_DROME
Klarsicht, isoform B
klar Dmel\CG17046, Klar, kls, marb, CG17046
2,045Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PDJ0M9PDJ0_DROME
Klarsicht, isoform G
klar Dmel\CG17046, Klar, kls, marb, CG17046
1,180Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PBH0M9PBH0_DROME
Klarsicht, isoform F
klar Dmel\CG17046, Klar, kls, marb, CG17046
1,636Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8JNH2A8JNH2_DROME
Klarsicht, isoform D
klar Dmel\CG17046, Klar, kls, marb, CG17046
1,823Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE014296 Genomic DNA Translation: AHN57913.1

NCBI Reference Sequences

More...RefSeqi		NP_001286888.1, NM_001299959.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0343526; FBpp0310130; FBgn0001316

Database of genes from NCBI RefSeq genomes

More...GeneIDi		38067

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AHN57913.1
RefSeqiNP_001286888.1, NM_001299959.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Proteomic databases

PRIDEiX2J8G9

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		38067

Genome annotation databases

EnsemblMetazoaiFBtr0343526; FBpp0310130; FBgn0001316
GeneIDi38067

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		38067
FlyBaseiFBgn0001316, klar
VEuPathDBiVectorBase:FBgn0001316

Phylogenomic databases

HOGENOMiCLU_271182_0_0_1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		38067, 0 hits in 1 CRISPR screen

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		klar, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		38067

Gene expression databases

BgeeiFBgn0001316, Expressed in wing disc (Drosophila) and 40 other tissues
ExpressionAtlasiX2J8G9, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR039906, Anc-1-like
PANTHERiPTHR21524, PTHR21524, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiX2J8G9_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: X2J8G9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 11, 2014
Last sequence update: June 11, 2014
Last modified: January 19, 2022
This is version 61 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
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