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Entry version 52 (02 Jun 2021)
Sequence version 1 (11 Jun 2014)
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Protein

3C-like proteinase

Gene

orf1ab

Organism
Porcine coronavirus HKU15
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonucleaseARBA annotation, ExonucleaseARBA annotation, HelicaseARBA annotation, Hydrolase, MethyltransferaseARBA annotation, Nuclease, Nucleotidyltransferase, Protease, RNA-bindingARBA annotation, RNA-directed RNA polymeraseARBA annotation, Thiol proteaseARBA annotation, Transferase
Biological processActivation of host autophagy by virusARBA annotation, Host-virus interaction, Viral RNA replicationARBA annotation
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
3C-like proteinaseARBA annotation (EC:2.7.7.48ARBA annotation, EC:3.6.4.12ARBA annotation, EC:3.6.4.13ARBA annotation)
Alternative name(s):
Growth factor-like peptideARBA annotation
HelicaseARBA annotation
NendoUARBA annotation
Non-structural protein 10ARBA annotation
Non-structural protein 2ARBA annotation
Non-structural protein 3ARBA annotation
Non-structural protein 4ARBA annotation
Non-structural protein 6ARBA annotation
Non-structural protein 7ARBA annotation
Non-structural protein 8ARBA annotation
Non-structural protein 9ARBA annotation
ORF1ab polyproteinARBA annotation
RNA-directed RNA polymeraseARBA annotation
Replicase polyprotein 1abARBA annotation
Uridylate-specific endoribonucleaseARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:orf1abImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPorcine coronavirus HKU15Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1159905 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraePisuviricotaPisoniviricetesNidoviralesCornidovirineaeCoronaviridaeOrthocoronavirinaeDeltacoronavirusBuldecovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000124223 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1507 – 1531HelicalSequence analysisAdd BLAST25
Transmembranei1599 – 1627HelicalSequence analysisAdd BLAST29
Transmembranei1633 – 1655HelicalSequence analysisAdd BLAST23
Transmembranei2004 – 2025HelicalSequence analysisAdd BLAST22
Transmembranei2291 – 2317HelicalSequence analysisAdd BLAST27
Transmembranei2329 – 2362HelicalSequence analysisAdd BLAST34
Transmembranei2374 – 2404HelicalSequence analysisAdd BLAST31
Transmembranei2823 – 2841HelicalSequence analysisAdd BLAST19
Transmembranei2847 – 2865HelicalSequence analysisAdd BLAST19
Transmembranei2877 – 2895HelicalSequence analysisAdd BLAST19
Transmembranei2915 – 2934HelicalSequence analysisAdd BLAST20
Transmembranei2946 – 2964HelicalSequence analysisAdd BLAST19
Transmembranei2976 – 2997HelicalSequence analysisAdd BLAST22
Transmembranei3009 – 3033HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Host cytoplasmARBA annotation, Host membraneARBA annotation, Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

X2G6C4
With#Exp.IntAct
itself3EBI-25590436,EBI-25590436

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
X2G6C4

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini939 – 1108MacroInterPro annotationAdd BLAST170
Domaini2509 – 2816Peptidase C30InterPro annotationAdd BLAST308
Domaini4230 – 4391RdRp catalyticInterPro annotationAdd BLAST162
Domaini4549 – 4632CV ZBDInterPro annotationAdd BLAST84
Domaini4791 – 5167(+)RNA virus helicase C-terminalInterPro annotationAdd BLAST377

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni745 – 811DisorderedSequence analysisAdd BLAST67
Regioni873 – 906DisorderedSequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi793 – 811Polar residuesSequence analysisAdd BLAST19
Compositional biasi873 – 887Polar residuesSequence analysisAdd BLAST15
Compositional biasi888 – 902Acidic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the coronaviruses polyprotein 1ab family.ARBA annotation

Keywords - Domaini

RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd21409, 1B_cv_Nsp13-like, 1 hit
cd20762, capping_2-OMTase_Nidovirales, 1 hit
cd21512, cv_gamma-delta_Nsp2_IBV-like, 1 hit
cd21473, cv_Nsp4_TM, 1 hit
cd21561, deltaCoV-Nsp6, 1 hit
cd21657, deltaCoV_Nsp14, 1 hit
cd21668, deltaCoV_Nsp5_Mpro, 1 hit
cd21590, deltaCoV_RdRp, 1 hit
cd21169, M_dcv_Nsp15-like, 1 hit
cd21557, Macro_X_Nsp3-like, 1 hit
cd21161, NendoU_cv_Nsp15-like, 1 hit
cd21172, NTD_dcv_Nsp15-like, 1 hit
cd21401, ZBD_cv_Nsp13-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.420, 1 hit
1.10.1840.10, 1 hit
2.20.25.360, 1 hit
2.40.10.10, 2 hits
2.40.10.250, 1 hit
3.40.220.10, 1 hit
3.40.50.11580, 1 hit
3.90.70.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027351, (+)RNA_virus_helicase_core_dom
IPR043608, CoV_NSP15_M
IPR043606, CoV_NSP15_N
IPR043611, CoV_NSP3_C
IPR043612, CoV_NSP4_N
IPR043502, DNA/RNA_pol_sf
IPR037227, EndoU-like
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR044371, Macro_X_NSP3-like
IPR043609, NendoU_nidovirus
IPR036333, NSP10_sf_CoV
IPR044343, NSP13_1B_dom_CoV
IPR027352, NSP13_ZBD_CoV-like
IPR009466, NSP14_CoV
IPR044317, NSP14_deltaCoV
IPR044324, NSP15_M_deltaCoV
IPR043174, NSP15_middle_sf
IPR042515, NSP15_N_CoV
IPR044331, NSP15_N_deltaCoV
IPR044401, NSP15_NendoU_CoV
IPR009461, NSP16_CoV-like
IPR044383, NSP2_IBV-like
IPR032505, NSP4_C_CoV
IPR038123, NSP4_C_sf_CoV
IPR044307, NSP5_Mpro_deltaCoV
IPR043610, NSP6_CoV
IPR044365, NSP6_deltaCoV
IPR014829, NSP8_CoV-like
IPR037230, NSP8_sf_CoV
IPR014822, NSP9_CoV
IPR036499, NSP9_sf_CoV
IPR027417, P-loop_NTPase
IPR013016, Peptidase_C16_CoV
IPR008740, Peptidase_C30_CoV
IPR043477, Peptidase_C30_dom3_CoV
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR043503, PLpro_palm_finger_dom_CoV
IPR044354, RdRp_deltaCoV
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus
IPR009469, RNA_pol_N_coronovir
IPR018995, RNA_synth_NSP10_CoV
IPR029063, SAM-dependent_MTases

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06471, CoV_Methyltr_1, 1 hit
PF06460, CoV_Methyltr_2, 1 hit
PF09401, CoV_NSP10, 1 hit
PF19215, CoV_NSP15_C, 1 hit
PF19216, CoV_NSP15_M, 1 hit
PF19219, CoV_NSP15_N, 1 hit
PF19218, CoV_NSP3_C, 1 hit
PF16348, CoV_NSP4_C, 1 hit
PF19217, CoV_NSP4_N, 1 hit
PF19213, CoV_NSP6, 1 hit
PF08717, CoV_NSP8, 1 hit
PF08710, CoV_NSP9, 1 hit
PF08715, CoV_peptidase, 1 hit
PF06478, CoV_RPol_N, 1 hit
PF01661, Macro, 1 hit
PF05409, Peptidase_C30, 1 hit
PF00680, RdRP_1, 1 hit
PF01443, Viral_helicase1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00506, A1pp, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101816, SSF101816, 1 hit
SSF142877, SSF142877, 1 hit
SSF143076, SSF143076, 1 hit
SSF144246, SSF144246, 1 hit
SSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 1 hit
SSF52949, SSF52949, 1 hit
SSF53335, SSF53335, 2 hits
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51653, CV_ZBD, 1 hit
PS51442, M_PRO, 1 hit
PS51154, MACRO, 1 hit
PS51657, PSRV_HELICASE, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

X2G6C4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKNKSKRDA IALPENVPPP LQLFIHVAAA EEGHPKVTTY LGNYNLYATK
60 70 80 90 100
APPGVQVLSA KTSLTDFENV FGAQPTLRSI RNLVCEARSA EWTISKNAFA
110 120 130 140 150
LKATQLDYSD AVLRAMIRFC PPKVSTLAAF ALFGRLVKIE DKELAELARD
160 170 180 190 200
TALELAYTAK IGTSLADTRS VSLIHKDAYL TLSNEVVGVT FTAALMAKAT
210 220 230 240 250
TVNGAMQYSN FYLYPRATIK VTDGKAEAIA TKPLSAATKG KQITEDVNLL
260 270 280 290 300
PDYQQLLVDQ VTGTEVKVGA LTYVKTTDSP PLYFPKVKGG VIGIALKQQG
310 320 330 340 350
TAAKKLNVVF HAQPDDVLLA FIQLQQFLNR TSDSSVEITD CQSYEVSPTV
360 370 380 390 400
TVKIGPSKPG DVIVATDEEY LKCFETPEVG RLYKVFQTQS WAIIERAFSS
410 420 430 440 450
LKIRVSKALS AFISFLQNLA DNFTAISGVV TALIRELQDL TLDVATRITN
460 470 480 490 500
IQFVYRAGKL IVDTTSVIAK LFQPFCDFIS PFLRKVAGFA IYTVGNRMLM
510 520 530 540 550
FTSTGTFLLT KATTKILNKA KYIFDVEPEY PVDVTTSKVV VHEALQQTDT
560 570 580 590 600
KPTRALEAVD VVVGNTVLQM ATDGTAFYPS DGTHASLPGF KAGSDELFIS
610 620 630 640 650
FNCDLFDDET NAQINETLAA YELNQLVAPG DSTPRQIATL VVDTLADAIT
660 670 680 690 700
DHFPEKTIDL PEDYQVFSDH DDLPLAQYHI PDHLSLYIQA MEGEDDSGDE
710 720 730 740 750
ICIEDDDYDC PQADEDTEGV IPQQWELPDV DKFLLKIQER KTSSDEVLSV
760 770 780 790 800
DVYPKPEPVG NVGIDDSASE KKPNGDSVPD PEVHPTLESV DVERPTETAN
810 820 830 840 850
QAVEDKPSDT TFVVDEEQLQ ESTPEHELRS YEGEFDSDDE IIIPIVPVTP
860 870 880 890 900
ADLKPQTITI KEYFKSEKLE TINEGSTESV TQSDDSFDES FVDAESDDPQ
910 920 930 940 950
DPAVYDDTTI ITDSTDVGDE PETTLATIVN TPLTLDNNLP PEAIKQPSPT
960 970 980 990 1000
KVELVVGELA SIKFDNSVLV NPANAQLTNG GGAARAIAKL AGPKYQEYCN
1010 1020 1030 1040 1050
SVAPISGPLT TDSFDAKKFG VACILHVVPP KGSDPNVQEL LYQAYKSILT
1060 1070 1080 1090 1100
EPAHYVIPIL GAGIFGCNPV HSLDAFRKAC PSDIGRVTLV TMNKNHLQVW
1110 1120 1130 1140 1150
DALNRTIVRT TTDYDQVTTK ALTPQGVLEA NLFDGEDFVQ EPKPGQIYLE
1160 1170 1180 1190 1200
VTEEVQNQAK ELDLNLQQYC VYLKTCHHKW VVSRTNGLMH LKQKDNNCFV
1210 1220 1230 1240 1250
SAGVNLFQNT AYQLRPAIDA LYREYLNGNP NRFVAWIYAS TNRRVGEMGC
1260 1270 1280 1290 1300
PQQVISLLVS NSDAAFSATT ACCNTYFNHT GVISVAREYD PIQPKVYCMK
1310 1320 1330 1340 1350
CDVWTPFTPQ SGKGAVAIGI SADEPTGPAI KFAAAHCWYT NGKKTVNGYD
1360 1370 1380 1390 1400
TKANVVATYH RFDVPKPQLV EDVVALPTKN DFEVLNVEEL PQDSVLHLDP
1410 1420 1430 1440 1450
PPVQALQPKA NQHIEILENP DYLDILDLWI RKPKFILVKS WSVLGRALCK
1460 1470 1480 1490 1500
AGKVVFVSAS LLTRFYNYLV EIGALDSTIR LSVDLTCKFV RTVLPSSNTV
1510 1520 1530 1540 1550
HKTCLGLYYS AQTLFVSLAP FLMLPAVVSL LNSGYTIGTY LYAKTGWPCN
1560 1570 1580 1590 1600
YNATQHFDYN SYCAGDLVCQ ACFDGQDSLH LYPHLRVNQQ PLQTTDYTVY
1610 1620 1630 1640 1650
ALSLILLLAN MTLVMGTLIV TFFVNFYGVQ IPFYGTLLID YQSALVITFS
1660 1670 1680 1690 1700
VYYFYKVMKF FRHLTHGCKI PTCVVCAKLR TPPTITVETV VQGRKYPSVI
1710 1720 1730 1740 1750
ETNGGFTICK EHNFYCKDCS LQTPGTFIPT EAIESLSRAT RLSVKPTAPA
1760 1770 1780 1790 1800
FLLARDVECQ TDVVVARAMH NQNAHVCISK YSDIRTVDQL LKPTPLFSYT
1810 1820 1830 1840 1850
PDVIIAADFD NRGSLKTAKE LAVVLSMDLK RTIIIIDQAY SRPIDNYQEV
1860 1870 1880 1890 1900
ASRIEKYYPV AKITPTGDIF TDIKQATNGQ ASDSAINAAV LAVQRGLDFT
1910 1920 1930 1940 1950
IDNPNNILPH YAFDFSTLNA EDQSTILESG CAKGNLKGTN VGVVLSASLV
1960 1970 1980 1990 2000
TRLSQQAIRV IANAASRNGV TCAVTPSTLV MRGNIATQPL TRIKAGAPPM
2010 2020 2030 2040 2050
RQKILCVILA LAIVYFAAMA FGFLASQITL NTVPTIKSDI RASTFYVVRD
2060 2070 2080 2090 2100
GVLDTVRSND KCFANKFLAF DSFIQAPYTN SPDCPVVVGV VDVTTHSIPG
2110 2120 2130 2140 2150
IPAGVIHRDG LILNIYEQSL YETHQRQSMV RDALSLKTAN LFNLGKRVVV
2160 2170 2180 2190 2200
GYTQHEVVVG TSYFNSPALF NAKCTFLQYQ DTRQLYCYDT VPTEHKLYSD
2210 2220 2230 2240 2250
VLPHVEYKAI DINGDLVPFK IPEQIMFYPH IVRYTSNSYC RMGHCFNTNP
2260 2270 2280 2290 2300
GICISFTDEF PYSENVKPGV YCADTSLQLF SNLVLGTVSG IHIFTSTAAL
2310 2320 2330 2340 2350
LGSTIVIILC VVAVLAVQRF FKEYTTFVMY TCGLALVNIV GIALMYKCLV
2360 2370 2380 2390 2400
FAIFYYAIYL YFVLTFPSFK RNVALFYFAV VIVPHVSNMQ LLALIVCSII
2410 2420 2430 2440 2450
YFLYTYVHTV AKTAGKFSSF LDAAKATFVI DNEKYVLLKD LAGAEFDQYL
2460 2470 2480 2490 2500
ASYNKYKYFS GTASDKDYDK VCMAFLAKAL SSFREGGGSQ LYTPPKFAVV
2510 2520 2530 2540 2550
QSLKTKLQAG IKILLHPSGV VERCMVSVVY NGSALNGIWL KNVVYCPRHV
2560 2570 2580 2590 2600
IGKFRGDQWT HMVSIADCRD FIVKCPIQGI QLNVQSVKMV GALLQLTVHT
2610 2620 2630 2640 2650
NNTATPDYKF ERLQPGSSMT IACAYDGIVR HVYHVVLQLN NLIYASFLNG
2660 2670 2680 2690 2700
ACGSVGYTLK GKTLYLHYMH HIEFNNKTHS GTDLEGNFYG PYVDEEVIQQ
2710 2720 2730 2740 2750
QTAFQYYTDN VVAQLYAHLL TVDARPKWLA QSQISIEDFN SWAANNSFAN
2760 2770 2780 2790 2800
FPCEQTNMSY IMGLSQTARV PVERILNTII QLTTNRDGAC IMGSYDFECD
2810 2820 2830 2840 2850
WTPEMVYNQA PISLQSGVVK KTCTWFFHFL FMAITMLLAA MHVFPVHLYP
2860 2870 2880 2890 2900
IVLPCFTVVA FLLTLTIKHT VVFTTTYLLP SLLMMVVNAN TFWIPNTFLR
2910 2920 2930 2940 2950
TCYETIFGSP IAQRLYGYTV ALYMLIYAGL AINYTLKTLR YRATSFLSFC
2960 2970 2980 2990 3000
MQWFQYGYVA HIAYKLLNKP WTESLLFTAF TMLTSHPLLA ALSWWLAGRV
3010 3020 3030 3040 3050
TLPIIMPDLA IRVLAYNVIG YVICVRFGLM WLANRFTTVP MGTYQYMVSV
3060 3070 3080 3090 3100
EQLKYMMAVK MSPPRNAFEV LIANIRLLGL GGNRNIAVST VQNKILDAKA
3110 3120 3130 3140 3150
TAVVVANLLE KAGVTNKHAI CKKIVKLHND TLKATTYEEV EVALVKLLSH
3160 3170 3180 3190 3200
IIEFLPTDQV DAYLADAANA QHVNTYFDNL LENKAVVQAV ADININLDSY
3210 3220 3230 3240 3250
RIYKEADAIY KRSVEMNESP QEQKKKLKAV NIAKAEWERE AASQRKLEKL
3260 3270 3280 3290 3300
ADAAMKSMYL AERAEDRRIK LTSGLTAMLY HMLRRLDSDR VKALFECAKA
3310 3320 3330 3340 3350
QILPIHAVVG ISNDNLKVIF NDKDSYSHYV EGNTLIHKGV RYTIVKKLSL
3360 3370 3380 3390 3400
DNAPIEGVPE EFPVVVETVR EGVPQLQNNE LCLRNVFTAQ NTAQDFNGNE
3410 3420 3430 3440 3450
STVKSFYVTR TGKKILVAIT STKDNLKTVT CLTETGKTVL NLDPPMRFAH
3460 3470 3480 3490 3500
TVGGKQSVVY LYFIQNISSL NRGMVIGHIS ETTILQASGT QIEYQQNASL
3510 3520 3530 3540 3550
LTYLAFAVDP KTAYLKHLAD GGSPIQGCIQ MIATMGPGFA VTTKPQPNEH
3560 3570 3580 3590 3600
QYSYGGASIC LYCRAHIPHP GVDGRCPYKG RFVHIDKDKE PVSFALTHEP
3610 3620 3630 3640 3650
CSSCQRWVNY DCTCGSSLQN SAYLNRVTGS SDARLEPLQP GTQPDAVKRA
3660 3670 3680 3690 3700
FHVHNDTTSG IFLSTKSNCA RFKTTRSALP LPNKGEVELY FVTKQCAAKV
3710 3720 3730 3740 3750
FEIEEECYNA LSTELYTTDD TFGVLAKTEF FKFDKIPNVN RQYLTKYTLL
3760 3770 3780 3790 3800
DLAYALRHLS TSKDVIQEIL ITMCGTPEDW FGENWFDPIE NPSFYKEFHK
3810 3820 3830 3840 3850
LGDILNRCVL NANKFASACI DAGLVGILTP DNQDLLGQIY DFGDFIITQP
3860 3870 3880 3890 3900
GNGCVDLASY YSYLMPIMSM THMLKCECMD SDGNPLEYDG FQYDFTDFKL
3910 3920 3930 3940 3950
GLFEKYFKYW DRPYHPNTVE CPDDRCVLHC ANFNVLFAMC IPNTAFGNLC
3960 3970 3980 3990 4000
SRATVDGHLV VQTVGVHLKE LGIVLNQDVT THMANINLNT LLRLVGDPTT
4010 4020 4030 4040 4050
IASVSDKCVD LRTPCQTLAT MSSGIAKQSV KPGHFNQHFY KHLLDSNLLD
4060 4070 4080 4090 4100
QLGIDIRHFY YMQDGEAAIT DYSYYRYNTP TMVDIKMFLF CLEVADKYLE
4110 4120 4130 4140 4150
PYEGGCINAQ SVVVSNLDKS AGYPFNKLGK ARNYYDMTHA EQNQLFEYTK
4160 4170 4180 4190 4200
RNVLPTLTQM NLKYAISAKD RARTVAGVSI ISTMTNRQYH QKMLKSISLA
4210 4220 4230 4240 4250
RNQTIVIGTT KFYGGWDNML RRLMCNINNP ILVGWDYPKC DRSMPNMLRI
4260 4270 4280 4290 4300
AASCLLARKH TCCNQSQRFY RLANECCQVL SEVVVSGNNL YVKPGGTSSG
4310 4320 4330 4340 4350
DATTAYANSV FNILQVVSAN VATFLSTSTT THLNKDIADL HRSLYEDIYR
4360 4370 4380 4390 4400
GDSNDITVIN RFYQHLQSYF GLMILSDDGV ACIDSAVAKA GAVADLDGFR
4410 4420 4430 4440 4450
DILFYQNNVY MADSKCWTET DMNVGPHEFC SQHTVLAEHD GKPYYLPYPD
4460 4470 4480 4490 4500
VSRILGACIF VDDVNKADPV QNLERYISLA IDAYPLTKVD PIKGKVFYLL
4510 4520 4530 4540 4550
LDYIRVLAQE LQDGILDAFQ SLTDMSYVNN FMNEAFYAQM YEQSPTLQAS
4560 4570 4580 4590 4600
GVCVVCNSPT ILRCGDCIRR PLLCCVCAYQ HVTQTTHKRI IAINNYICSV
4610 4620 4630 4640 4650
ENCNEDNVEK LFISGTAIYC ENHKPTLCIP IVANGSVFGI YRHTARGSDD
4660 4670 4680 4690 4700
IDLFNELATS NYDTIEPYQK ANRAPLSLML FAAETIKALE ESIKKSYATA
4710 4720 4730 4740 4750
TVKDVYDQRF IKLLWEQGKK PPPITKNHIF TGYHFNKNGK TQVGDYILAK
4760 4770 4780 4790 4800
TDGSDTYTYR GTSTYKLQTG DVLVLMAHVV TPLSAPPVLT QTTYVRKSLL
4810 4820 4830 4840 4850
PDSVGASYYV QHFKSYNEIA MQRVTTVLGP PGTGKSTFAI GLAKYFPSAR
4860 4870 4880 4890 4900
ICYTASSHAA IDALCEKAFK TIPVGQCSRI VPTRTTVECF QEFVVNNTTA
4910 4920 4930 4940 4950
QYIFSTINAL PDIKCDIVVV DEVSMLTNYE LSSVNARLVY NHIVYVGDPY
4960 4970 4980 4990 5000
QLPSPRTMLT SGQLSPADYN VVTDIMVHAG ADVMLDMCYR CPREIVETVS
5010 5020 5030 5040 5050
KLVYDNKLKA AKPNSRQCYK TIVNFGPGDV AHEGQSAYNE AQLRFALAFR
5060 5070 5080 5090 5100
QQKRWDNVTF ISPYNAMNVK ASLAGFSTQT VDSSQGSEYD YVIFCVTTDS
5110 5120 5130 5140 5150
AHALNMARLN VALTRAKIGI LVVFRQANEL YNSLQFESID SQLQSSAEKN
5160 5170 5180 5190 5200
LTPLFKRCGY EYNGVHPAHA LTWHDCGAEY RCEEPLAKLV GVADGTLISY
5210 5220 5230 5240 5250
KTLVSTLGFL PSLKIDAYHN MFLTRDACRT YVQSWIGIDV EAAHAIKPNT
5260 5270 5280 5290 5300
GTNLPLQIGF STGKNFSVTP EGIWVNEHGS CTEPVPAKIP PGEQFRHLKK
5310 5320 5330 5340 5350
DMRQARPWKV VRREIATHIA EVAPHTDYIC FVTWAHQLEL ATMRYFVKLG
5360 5370 5380 5390 5400
MEEKCFCGRR ACFTNGTEFA CKAHHSLTIP QCDYVYNPFL IDVATWGFSG
5410 5420 5430 5440 5450
RLSTNHDAVC TYHANAHVAS ADAIMTVCLA IHELFSTVDW NFEFPVTAEQ
5460 5470 5480 5490 5500
SQLNKACRLV QANYLNILLT TTKATVVHDI GNPKGIPIVR KPGVKYHFYD
5510 5520 5530 5540 5550
QAPIVKHVQK LKYKPEMEAR FTDGLTMFWN CNVDTYPANA LVCRYDTHRQ
5560 5570 5580 5590 5600
KHLIGPNGSA LYVNKHAFLT PEMHTYATHK LNLAPLIYYS TTDCSSEQPI
5610 5620 5630 5640 5650
VVTYRDCVTR CNTGKTLCPN HALEYQEFIN AYNLMARHGF NVYIPRNVNV
5660 5670 5680 5690 5700
YNCWLTFTNL QNLENLAYNC YYKNCNAHVD GQLDVVINNN AVYAKVDNNL
5710 5720 5730 5740 5750
VKLFDNRTNL PVSVAFEHYT NRHTRSLPTT QLLSGLGVTA TRNFTVWFDN
5760 5770 5780 5790 5800
DTIFQYTINV STYTDIDPST HVVLCDDRYG TDWSQFNQLP NAVFLTKTKV
5810 5820 5830 5840 5850
KKTEPFVCTA LTLNGVAIDG EELYIYVRYN NQLTTFATTC TQGRNVEQFI
5860 5870 5880 5890 5900
PKTPMERDFL EMSQQSFIQQ HQLQELGVEH IIYGDDSSPV IGGTHTLISL
5910 5920 5930 5940 5950
VKNKFEHQLV NHVYNPVQNC VVTSPNASSK NVCTVLDVLL DDYIDIIRQA
5960 5970 5980 5990 6000
HASYTSKSKV FTVSIDNQQI RFMLWHDEQV KTCYPILQSL TNGYQMPSVY
6010 6020 6030 6040 6050
KTLVTDLQPA DIPNYHSYTP RVPGVVKNVI KYRQLFNYIV KKDRLAVPHN
6060 6070 6080 6090 6100
MTVLHLGAAS ALGTAPGSSV IKQMFPEGTV LIDLDIREFT SDANQIIVTD
6110 6120 6130 6140 6150
YRTYIPPHHV DVIFSDLYCC DDIHFFDNLI RIVKERLALG GSIFVKITEH
6160 6170 6180 6190 6200
SFSPELYSLA GWFDDYQLFC TAVNASSSEA FLCCFNYLGL AKENINGFNL
6210 6220 6230 6240 6250
HASYIQWRNE IALTPTYSPL ADNPATACKL KATPIISARE LEKKPILRYL
6260
VASGRLLVRP PECRELY
Length:6,267
Mass (Da):700,055
Last modified:June 11, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAF100075E6666E0A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
KJ462462 Genomic RNA Translation: AHN16219.1

Keywords - Coding sequence diversityi

Ribosomal frameshiftingARBA annotation

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KJ462462 Genomic RNA Translation: AHN16219.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5YM6X-ray1.80A/B/C/D3378-3486[»]
5YM8X-ray1.99A/B3385-3486[»]
SMRiX2G6C4
ModBaseiSearch...
PDBe-KBiSearch...

Family and domain databases

CDDicd21409, 1B_cv_Nsp13-like, 1 hit
cd20762, capping_2-OMTase_Nidovirales, 1 hit
cd21512, cv_gamma-delta_Nsp2_IBV-like, 1 hit
cd21473, cv_Nsp4_TM, 1 hit
cd21561, deltaCoV-Nsp6, 1 hit
cd21657, deltaCoV_Nsp14, 1 hit
cd21668, deltaCoV_Nsp5_Mpro, 1 hit
cd21590, deltaCoV_RdRp, 1 hit
cd21169, M_dcv_Nsp15-like, 1 hit
cd21557, Macro_X_Nsp3-like, 1 hit
cd21161, NendoU_cv_Nsp15-like, 1 hit
cd21172, NTD_dcv_Nsp15-like, 1 hit
cd21401, ZBD_cv_Nsp13-like, 1 hit
Gene3Di1.10.150.420, 1 hit
1.10.1840.10, 1 hit
2.20.25.360, 1 hit
2.40.10.10, 2 hits
2.40.10.250, 1 hit
3.40.220.10, 1 hit
3.40.50.11580, 1 hit
3.90.70.90, 1 hit
InterProiView protein in InterPro
IPR027351, (+)RNA_virus_helicase_core_dom
IPR043608, CoV_NSP15_M
IPR043606, CoV_NSP15_N
IPR043611, CoV_NSP3_C
IPR043612, CoV_NSP4_N
IPR043502, DNA/RNA_pol_sf
IPR037227, EndoU-like
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR044371, Macro_X_NSP3-like
IPR043609, NendoU_nidovirus
IPR036333, NSP10_sf_CoV
IPR044343, NSP13_1B_dom_CoV
IPR027352, NSP13_ZBD_CoV-like
IPR009466, NSP14_CoV
IPR044317, NSP14_deltaCoV
IPR044324, NSP15_M_deltaCoV
IPR043174, NSP15_middle_sf
IPR042515, NSP15_N_CoV
IPR044331, NSP15_N_deltaCoV
IPR044401, NSP15_NendoU_CoV
IPR009461, NSP16_CoV-like
IPR044383, NSP2_IBV-like
IPR032505, NSP4_C_CoV
IPR038123, NSP4_C_sf_CoV
IPR044307, NSP5_Mpro_deltaCoV
IPR043610, NSP6_CoV
IPR044365, NSP6_deltaCoV
IPR014829, NSP8_CoV-like
IPR037230, NSP8_sf_CoV
IPR014822, NSP9_CoV
IPR036499, NSP9_sf_CoV
IPR027417, P-loop_NTPase
IPR013016, Peptidase_C16_CoV
IPR008740, Peptidase_C30_CoV
IPR043477, Peptidase_C30_dom3_CoV
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR043503, PLpro_palm_finger_dom_CoV
IPR044354, RdRp_deltaCoV
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus
IPR009469, RNA_pol_N_coronovir
IPR018995, RNA_synth_NSP10_CoV
IPR029063, SAM-dependent_MTases
PfamiView protein in Pfam
PF06471, CoV_Methyltr_1, 1 hit
PF06460, CoV_Methyltr_2, 1 hit
PF09401, CoV_NSP10, 1 hit
PF19215, CoV_NSP15_C, 1 hit
PF19216, CoV_NSP15_M, 1 hit
PF19219, CoV_NSP15_N, 1 hit
PF19218, CoV_NSP3_C, 1 hit
PF16348, CoV_NSP4_C, 1 hit
PF19217, CoV_NSP4_N, 1 hit
PF19213, CoV_NSP6, 1 hit
PF08717, CoV_NSP8, 1 hit
PF08710, CoV_NSP9, 1 hit
PF08715, CoV_peptidase, 1 hit
PF06478, CoV_RPol_N, 1 hit
PF01661, Macro, 1 hit
PF05409, Peptidase_C30, 1 hit
PF00680, RdRP_1, 1 hit
PF01443, Viral_helicase1, 1 hit
SMARTiView protein in SMART
SM00506, A1pp, 1 hit
SUPFAMiSSF101816, SSF101816, 1 hit
SSF142877, SSF142877, 1 hit
SSF143076, SSF143076, 1 hit
SSF144246, SSF144246, 1 hit
SSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 1 hit
SSF52949, SSF52949, 1 hit
SSF53335, SSF53335, 2 hits
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS51653, CV_ZBD, 1 hit
PS51442, M_PRO, 1 hit
PS51154, MACRO, 1 hit
PS51657, PSRV_HELICASE, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiX2G6C4_9NIDO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: X2G6C4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 11, 2014
Last sequence update: June 11, 2014
Last modified: June 2, 2021
This is version 52 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
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