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Entry version 30 (12 Aug 2020)
Sequence version 1 (14 May 2014)
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Protein

Endonuclease

Gene
N/A
Organism
Acyrthosiphon pisum (Pea aphid)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
EndonucleaseARBA annotation (EC:2.7.7.49ARBA annotation)
Alternative name(s):
Reverse transcriptaseARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAcyrthosiphon pisum (Pea aphid)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7029 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraHemipteraSternorrhynchaAphidomorphaAphidoideaAphididaeMacrosiphiniAcyrthosiphon
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007819 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini433 – 447CCHC-typeInterPro annotationAdd BLAST15
Domaini823 – 1007Reverse transcriptaseInterPro annotationAdd BLAST185
Domaini1257 – 1410MacroInterPro annotationAdd BLAST154
Domaini1507 – 1619Integrase catalyticInterPro annotationAdd BLAST113

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni69 – 124DisorderedSequence analysisAdd BLAST56
Regioni149 – 183DisorderedSequence analysisAdd BLAST35
Regioni1201 – 1250DisorderedSequence analysisAdd BLAST50

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi80 – 122PolarSequence analysisAdd BLAST43

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0017, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000384_9_6_1

Database of Orthologous Groups

More...
OrthoDBi
1416296at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.70.10, 1 hit
3.30.420.10, 1 hit
3.30.70.270, 2 hits
3.40.220.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR001584, Integrase_cat-core
IPR041588, Integrase_H2C2
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR021109, Peptidase_aspartic_dom_sf
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf
IPR000477, RT_dom
IPR041373, RT_RNaseH
IPR001878, Znf_CCHC
IPR036875, Znf_CCHC_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17921, Integrase_H2C2, 1 hit
PF17917, RT_RNaseH, 1 hit
PF00665, rve, 1 hit
PF00078, RVT_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00343, ZnF_C2HC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50630, SSF50630, 1 hit
SSF52949, SSF52949, 1 hit
SSF53098, SSF53098, 1 hit
SSF56672, SSF56672, 1 hit
SSF57756, SSF57756, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50994, INTEGRASE, 1 hit
PS51154, MACRO, 1 hit
PS50878, RT_POL, 1 hit
PS50158, ZF_CCHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

X1XU34-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSRIFDFKI KRSRGPKKVE NHCNIHYCEA AARIAVGTVY DRRDVIAHKL
60 70 80 90 100
VPLHRAVGTN NWLLVESKKK KKKRGLMNNS EDKNNSLEEQ NVLTTDSLQP
110 120 130 140 150
PIPTSRTSLT VRYSNPQDPT SEREVADITI PKSINNVVTK TTISNTEHFE
160 170 180 190 200
RTENKAQSEN SEQIKDYEDT TNSEQQELEK SYSKKRIDWT EDLINLDQSN
210 220 230 240 250
MANEPGSQQE KTVQNANAGT LTITEDQLSQ IINQKVQEAL RIRNVPQTIE
260 270 280 290 300
AMSSNQIGLQ DAIRLLPKSL DAIPRLVQAI QTRLTGKARQ VVKYQNFESW
310 320 330 340 350
EELRDLLKSN LEPQRTTQHL YQSLYATKQK TGMDILTYSK EIEALQNTII
360 370 380 390 400
EQETMGCTIE VAQALERTIK RQALQVFIEG LGDLKNYIKA RHPDSLFNAI
410 420 430 440 450
QAAREEEIVR KSSEESKKLY KPAATSKTQP GVCNVCKKPG HWARDCRYAK
460 470 480 490 500
ADNKKTKQNT SPAPVATVST VTCQYCKKTR AYERGGKLPT TGPFRRTPGR
510 520 530 540 550
EHQKRRDIFC RAYPIISKLT DHHLTCRTFQ TINPNVKFLV DSGSDLNLIK
560 570 580 590 600
ISTLRDEVIV YEEIIHHLRG ISEQLVKTIG YTTIGIQVGN RTIPTEFQVI
610 620 630 640 650
HPAFPIPHDG ILGKPFITGN QTIINYQTNE LTLPTDDEII SAHDTRTIIP
660 670 680 690 700
ARSEILVAIP APDFHEGETL LISAQTIGEV LMCSNTVNNV RDGCVLVSVM
710 720 730 740 750
NPREEAFELT TSHVNKFNIE QFNTAMVHTL SSQTETSYES SRITQLRSVL
760 770 780 790 800
RTEQLNPEEQ KSLVSICEQY TDIFYLEGDK LTNTEAVYHE INIPTATQPI
810 820 830 840 850
NERPYRLPFK HKQEINKQVK QWEEDGIITP SKSPWNAPLL VVPKKPDRDG
860 870 880 890 900
VVQYRICVDF RKLNHISSGD AYPLPNITDI LDQLGKSRYY TTLDLAQGYH
910 920 930 940 950
QVKMHPDYKE RTAFFTERGH FEFQRVPFGL KGAPATFQRL MNTVLTGLNV
960 970 980 990 1000
LKTFVYLDDI IIYARDIPDH SKKLQEVFER LRQFNLRLQP TKCEFMRKEV
1010 1020 1030 1040 1050
NYLGHVITDQ GVRPDPKKVQ CVMDYPIPKN SKDIKSFLGL SGYYRRFIPD
1060 1070 1080 1090 1100
YGKIAKPLTS LLKKDVEFKW SDLCQKAFED LKNALTNEPL LQYPDFNQTF
1110 1120 1130 1140 1150
NLTCDASEQN YSTTERELCA IIWGVKQFRP YLLGQEFNII TDHRALTWLF
1160 1170 1180 1190 1200
NVKDPGSRLT RWRLKLEEYQ YKIQYKPGCN NTNADALSRI RVTTRAQTLR
1210 1220 1230 1240 1250
NEQIPESLVS TESTENPKPT NTTEYTESPK STDTTEFSKA SESSDTLESS
1260 1270 1280 1290 1300
NKTEAYQIFL NSDDSPTSNV TEIAGDIFST SSDTSLAHCV SADLKMSRGI
1310 1320 1330 1340 1350
ALQFRRRFGQ IHQLRQQENS IEEVIFLRVE DRTIFYLITK LHSWQKPTYQ
1360 1370 1380 1390 1400
SIFNCLQRLK LLCEEKQITK LACPRIGCRL DGLKWEEIRK MLCYIFKNKT
1410 1420 1430 1440 1450
IYISVYTKEE LSEDEKLRLI SEFHDTPLGG HQGVTRTFNR IYAQCHWKGM
1460 1470 1480 1490 1500
RKQIRDFIKK CPICQKNKIG NKPLKEPMII TTTSSRPFEK IFLDVVGPLP
1510 1520 1530 1540 1550
KSHKGNSFIL TLLNEIRFVC LHGIPQSLVT DCGTEFLSKV FKEVCNLLKI
1560 1570 1580 1590 1600
KQTSTTPYHP QSNGFLERSH RTLGEYLRNF IDKDPLNWDV KIPYAMFCHN
1610 1620 1630 1640 1650
STVHSATKYQ PYELVYGNPV AIPSSLLKEP EPRYNYEDYQ FEIKKQLQES
1660 1670 1680 1690
HAIAKKHLIE AKHKSKAQYD KSASNRIFEV GQKVLLKDKT SINKLTPK
Length:1,698
Mass (Da):195,111
Last modified:May 14, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB18D0438CCF4793C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
ABLF02008932 Genomic DNA No translation available.
ABLF02008933 Genomic DNA No translation available.

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
ACYPI56857-RA; ACYPI56857-PA; ACYPI56857

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABLF02008932 Genomic DNA No translation available.
ABLF02008933 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblMetazoaiACYPI56857-RA; ACYPI56857-PA; ACYPI56857

Phylogenomic databases

eggNOGiKOG0017, Eukaryota
HOGENOMiCLU_000384_9_6_1
OrthoDBi1416296at2759

Family and domain databases

Gene3Di2.40.70.10, 1 hit
3.30.420.10, 1 hit
3.30.70.270, 2 hits
3.40.220.10, 1 hit
InterProiView protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR001584, Integrase_cat-core
IPR041588, Integrase_H2C2
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR021109, Peptidase_aspartic_dom_sf
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf
IPR000477, RT_dom
IPR041373, RT_RNaseH
IPR001878, Znf_CCHC
IPR036875, Znf_CCHC_sf
PfamiView protein in Pfam
PF17921, Integrase_H2C2, 1 hit
PF17917, RT_RNaseH, 1 hit
PF00665, rve, 1 hit
PF00078, RVT_1, 1 hit
SMARTiView protein in SMART
SM00343, ZnF_C2HC, 1 hit
SUPFAMiSSF50630, SSF50630, 1 hit
SSF52949, SSF52949, 1 hit
SSF53098, SSF53098, 1 hit
SSF56672, SSF56672, 1 hit
SSF57756, SSF57756, 1 hit
PROSITEiView protein in PROSITE
PS50994, INTEGRASE, 1 hit
PS51154, MACRO, 1 hit
PS50878, RT_POL, 1 hit
PS50158, ZF_CCHC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiX1XU34_ACYPI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: X1XU34
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 14, 2014
Last sequence update: May 14, 2014
Last modified: August 12, 2020
This is version 30 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported, Transposable elementARBA annotation
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