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Entry version 48 (02 Jun 2021)
Sequence version 1 (14 May 2014)
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Protein
Submitted name:

Uncharacterized protein

Gene

100167965

Organism
Acyrthosiphon pisum (Pea aphid)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channelARBA annotation, Ion channel, Ligand-gated ion channelARBA annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.3.1.7, the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:100167965Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAcyrthosiphon pisum (Pea aphid)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7029 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraHemipteraSternorrhynchaAphidomorphaAphidoideaAphididaeMacrosiphiniAcyrthosiphon
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007819 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4445 – 4464HelicalSequence analysisAdd BLAST20
Transmembranei4627 – 4647HelicalSequence analysisAdd BLAST21
Transmembranei4710 – 4729HelicalSequence analysisAdd BLAST20
Transmembranei4897 – 4919HelicalSequence analysisAdd BLAST23
Transmembranei4973 – 4996HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane, Sarcoplasmic reticulumARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7029.ACYPI069453-PA

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini95 – 149MIRInterPro annotationAdd BLAST55
Domaini156 – 201MIRInterPro annotationAdd BLAST46
Domaini211 – 265MIRInterPro annotationAdd BLAST55
Domaini271 – 319MIRInterPro annotationAdd BLAST49
Domaini337 – 397MIRInterPro annotationAdd BLAST61
Domaini577 – 802B30.2/SPRYInterPro annotationAdd BLAST226
Domaini1015 – 1215B30.2/SPRYInterPro annotationAdd BLAST201
Domaini1460 – 1683B30.2/SPRYInterPro annotationAdd BLAST224

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1352 – 1480DisorderedSequence analysisAdd BLAST129
Regioni2815 – 2836DisorderedSequence analysisAdd BLAST22
Regioni2922 – 2949DisorderedSequence analysisAdd BLAST28
Regioni3586 – 3609DisorderedSequence analysisAdd BLAST24
Regioni3847 – 3870DisorderedSequence analysisAdd BLAST24
Regioni4494 – 4555DisorderedSequence analysisAdd BLAST62

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili461 – 481Sequence analysisAdd BLAST21
Coiled coili3784 – 3804Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1376 – 1390Pro residuesSequence analysisAdd BLAST15
Compositional biasi1391 – 1405Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1406 – 1426Polar residuesSequence analysisAdd BLAST21
Compositional biasi1427 – 1478Basic and acidic residuesSequence analysisAdd BLAST52
Compositional biasi2816 – 2836Polar residuesSequence analysisAdd BLAST21
Compositional biasi2922 – 2945Polar residuesSequence analysisAdd BLAST24
Compositional biasi4504 – 4528Polar residuesSequence analysisAdd BLAST25
Compositional biasi4529 – 4553Basic and acidic residuesSequence analysisAdd BLAST25

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2243, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000040_2_0_1

Database of Orthologous Groups

More...
OrthoDBi
5161at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
X1WXB1

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12877, SPRY1_RyR, 1 hit
cd12878, SPRY2_RyR, 1 hit
cd12879, SPRY3_RyR, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.920, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR013320, ConA-like_dom_sf
IPR011992, EF-hand-dom_pair
IPR014821, Ins145_P3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR013662, RIH_assoc-dom
IPR000699, RIH_dom
IPR013333, Ryan_recept
IPR003032, Ryanodine_rcpt
IPR009460, Ryanrecept_TM4-6
IPR035910, RyR/IP3R_RIH_dom_sf
IPR035761, SPRY1_RyR
IPR035764, SPRY2_RyR
IPR035762, SPRY3_RyR
IPR003877, SPRY_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF02815, MIR, 1 hit
PF08454, RIH_assoc, 1 hit
PF06459, RR_TM4-6, 1 hit
PF01365, RYDR_ITPR, 2 hits
PF02026, RyR, 4 hits
PF00622, SPRY, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00795, RYANODINER

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00472, MIR, 4 hits
SM00449, SPRY, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100909, SSF100909, 1 hit
SSF47473, SSF47473, 1 hit
SSF49899, SSF49899, 3 hits
SSF82109, SSF82109, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50188, B302_SPRY, 3 hits
PS50919, MIR, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

X1WXB1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADSEGSSEQ DDVSFLRTED MVCLSCTATG ERVCLAAEGF GNRHCYLENI
60 70 80 90 100
ADKNIPPDLS QCVFVIEQAL SVRALQELVT AASSQEGKGG TGSGHRTLLY
110 120 130 140 150
GNAILLRHQN SDMYLACLST SSSNDKLSFD VGLQEHSQGE ACWWTVHPAS
160 170 180 190 200
KQRSEGEKVR VGDDLILVSV ATERYLHTAK ENELSVVNAS FHVTHWSVQP
210 220 230 240 250
YGTGISRMKY VGYVFGGDVL RFFHGGDECL TIPSSWSDVS GQNIVIYEGG
260 270 280 290 300
SVMSQARSLW RLELARTKWA GGFINWYHPM RIRHLTTGRY LGVNENNELH
310 320 330 340 350
LVCREEATTA SSTFFLRQEK DDQKIILEDK DLEVIGAPII KYGDSTVLVQ
360 370 380 390 400
HSDTGLWLTY KSYETKKKGV GKVEEKQAVL HEEGKMDDGL DFSRSQEEES
410 420 430 440 450
RTARVIRKCS SLFTQFISGL ENLQSNRRSS LFCSFVNLNE MVMCLEDLIN
460 470 480 490 500
YFAQPEEDME HEEKQNRFRA LRNRQDLFQE EGILNLILEA IDKVNIITSQ
510 520 530 540 550
GFMVSLAGDE SGQSWDVISG YLYQLLAAII KGNHTNCAQF ANTNRLNWLF
560 570 580 590 600
SRLGSQASSE GTGMLDVLHC VLIDSPEALN MMKDEHIKVI ISLLEKHGRD
610 620 630 640 650
PKVLDVLCSL CVGNGVAVRS SQNNICDFLL PGKNLLLQTL LVDHVASVRP
660 670 680 690 700
NIFVGHVSGS AVYRKWYYEV AIDHVEQTTH LNPHIRIGWA NTAGYVPYPG
710 720 730 740 750
GGEKWGGNGV GDDLYSFGFD GSYLWTGGRK SEVMPGTQIS NIKKSDVIGC
760 770 780 790 800
ALDLTIPIIT FTLNGQLVQG AFRDFNLDGM FFPVISCSSK VSCRFLLGGD
810 820 830 840 850
HGRLKFTPPD EFSPLFETLL PQQILTIDPC FYFGNLNKCV LTGPWYVEDD
860 870 880 890 900
TAFVPNPVDT SMVTLPSYIE NIKDKLAENI HEMWAMNKIE AGWQYGDKRN
910 920 930 940 950
DTRKFHPCLI QFDKLPPAEK RYDSQLAVQT LKTVIALGYH ISIDNPPSRI
960 970 980 990 1000
KTVRLPNEPF MQSNGYKPAP LDLSAIILSG KMEELIDQLA ENTHNLWAKE
1010 1020 1030 1040 1050
RIQQGWTYGL NEELQMLRSP HLVPYSKVDD AIKKANRDTA SETVRTLLVY
1060 1070 1080 1090 1100
GYNLDPPTGE TNEATLLTDD NTNRYLTFRT YRAEKTYAVS SGKWYFEFEI
1110 1120 1130 1140 1150
LTSGPMRVGW ARFTCSPGYQ IGSDENSWAF DGYNEEKIYM GTAESFGRQW
1160 1170 1180 1190 1200
QVGDVVGVFL DLMDHTISFS MNGELLMDTL GGETTFSEVQ GEGFVPAFTL
1210 1220 1230 1240 1250
GLGQKAKLTF GQDVNSLKYF TTCGLQEGYE PFCVNMKRPV TYWYTKDQPI
1260 1270 1280 1290 1300
FENTDDFSSV IDVTRIPAGS DTPPCLKISH NTFETMEKAN WEFLRLSLPV
1310 1320 1330 1340 1350
ICLPSFIDEQ EKQRRWQEIR IRQHRLLSQS EHATPAHIEQ IMKSGFSMSD
1360 1370 1380 1390 1400
IKGLHRGYSD DPVENDEMMP NATPLPPRGK NQPPPPRPPR KGSLSRHDDL
1410 1420 1430 1440 1450
TIENEGKLNR SSSELNFNIY NHQNGDGQDI NKDDKKKRGR SPFRFFSRKK
1460 1470 1480 1490 1500
EGPSDNPKRA KTPDPVRNVD RSRNAAHRPN TLNERVTPQI RVSQMDLKLV
1510 1520 1530 1540 1550
PPAIPDRPGG PKAMSFTPTS AGIEFVGNEI FDLECLKLIN EYYYGVRIFP
1560 1570 1580 1590 1600
GQDPTHVYVG WVTTQYHLHT KDFSQNHVRK STVTIVDEHN RILESIDRQS
1610 1620 1630 1640 1650
CYMVRSDELY NEVTNDSSGK GASQGMAIGC FIDIATGMMS FTCEGKETSF
1660 1670 1680 1690 1700
KFKMEPDIKL FPAIFVEASS KEILQIELGR TSTTLPLSAA VLQNSERHVL
1710 1720 1730 1740 1750
PQFPPRLKVQ CLRPHQWARV PNDSLHIHTL KLSDIRGWSI LCEDPVSMIA
1760 1770 1780 1790 1800
LHIPEEDRCI DILELIEMEK LLSFHAHTLT LYAAVCYQAN YRAAHILCTH
1810 1820 1830 1840 1850
VNQKQLLYAI CSEYMSGPLR QGFYDLLIAL HLESHATTME VCKNEYIIPL
1860 1870 1880 1890 1900
GHELTTLYDD PQMGHSLRSL QTESVRPQMK MTEISDVIDN VRNLYSPYFP
1910 1920 1930 1940 1950
LQVVREYVMA ALEEAVLVNQ VHNRDPIGGS NENLFLPLLK LVDRLLLVGM
1960 1970 1980 1990 2000
LRDEDVEKLL IMINPETWDP EFQKDGPDEH RKGLLHMKMA EGAKLQMCYL
2010 2020 2030 2040 2050
LHHLCDIQLR HRVESIISFS YQFVNDIQID QLRRYNEIKQ SDLPSAVAAK
2060 2070 2080 2090 2100
KTREFRCPPR EQMNAILGFK NLDSDDKENC LIGDDLRERM NEFNEKLMKQ
2110 2120 2130 2140 2150
ISLVALQESE DDKSDLNNLN NEGKIKQFYN FINAVKDEGN EDGLNEQEKK
2160 2170 2180 2190 2200
IPEEIFRKVL ISTIVSWAEE TQIETPKLVR EMFSLLVRQY DSVGELIRAL
2210 2220 2230 2240 2250
EKTYVINFKT KEDVAQMWVG LSQIRSLLPV QMSQEEEELM RERLWKLVNN
2260 2270 2280 2290 2300
HTFFQHPDLI RVLRMHENVM AVMMNTLGRR AQAQSQPGGT PVTGQDGEIV
2310 2320 2330 2340 2350
PKEKDTSHEM VVACCRFLCY FCRTSRQNQK AMFDHFSFLL ENSNILLSRP
2360 2370 2380 2390 2400
SLRGSTPLDV AYSSLMENTE LALALREHYL EKIAIYLSRC GLQSNSELIE
2410 2420 2430 2440 2450
KGYPDLGWDP VEGERYLDFL RFCVWVNGES VEENANLVIR LLIRRPECLG
2460 2470 2480 2490 2500
PALRGEGEGL LRAIIDANKM SERITERRKF LEESGNQENI QLDHPLPESD
2510 2520 2530 2540 2550
EDEDYIDTGA AILNFYCTLV DLLGRCAPDS SVISLGKNES LRARAILRSL
2560 2570 2580 2590 2600
VPLEDLHGVL SLRFTLQNPA AGQDRPKSDM PSGLIPGHKQ SVVLFLERVY
2610 2620 2630 2640 2650
GIEMQELFFT LLEEAFLPDL RTATMLDRND GLESDMALAM NRYIGNSVLP
2660 2670 2680 2690 2700
LLIGHSKFYS ESDNYANLLD ATLHTVYRLS KNRMLTKGQR EAVSDFLVAL
2710 2720 2730 2740 2750
TSQMQPSMLL KLLRKLTVDV SNLSEYTTVA LRLLTLHYDR CAKYYGSTGG
2760 2770 2780 2790 2800
QGIYGASSDE EKRLTMMLFS NIFDSLSKMD YDPELFGKAL PCLSAIGCAL
2810 2820 2830 2840 2850
PPDYSLSKNH DDEWYGSKQN IQGPSDGPYN PQPINTNSIV LDNDLNSIVH
2860 2870 2880 2890 2900
KFSEHYHDAW ANRKLENGWV YGEQFNDVNK SHPRLKPYMM LSEYEKELYK
2910 2920 2930 2940 2950
EPVRESLKAL LAIGWSIEHS ENDAPLNNRG SVRRQSKSNE NVTPFDYHPN
2960 2970 2980 2990 3000
PIDMTNLTLT REMQNMAERL AENSHDIWAK KKKEEVMLCG GGIHNQLVPY
3010 3020 3030 3040 3050
DLLTDKEKKK DRERSQEFLK YLQYQGYKLH RPNRNGGPSE AEQLAAASTG
3060 3070 3080 3090 3100
ELRFSYSLLE KLIHYIDRAS INMKLLKPSG TFSRRSSFKI CTRDIKFFSK
3110 3120 3130 3140 3150
VVLPLVEKYF STHRNYFITV ATASSVLGAA SLKEKEMVAS LFCKLANLLR
3160 3170 3180 3190 3200
SKLMAFGADV RITVRCLQVL VKAIDAKSLV KNCPEFIRTS MLTFFHNIAD
3210 3220 3230 3240 3250
DLEHTIQNLH DSRYCYLRGT HLKTSTSLFY VNDVILPVLS SLFDHLAAYE
3260 3270 3280 3290 3300
YGNELLLNEI QVAAYKMLSS LYTLGTDTSL THDRKYLKVQ LERHRPAFGS
3310 3320 3330 3340 3350
CLGAFSSTFP VAFLEPHLNK HNQYSLLNRF ADSSLEAQDI MSRMEGTMPT
3360 3370 3380 3390 3400
LETVLNEVDQ FIESEKTYAD APHIIDVILP LLCSYLPYWW AQGPDNVALT
3410 3420 3430 3440 3450
TGNHVTMVTS EHMNCLLKNV LKLIKKNIGN DNAPWMTQIA AYTQQIIINS
3460 3470 3480 3490 3500
SEELLKDPFL PLAERVKKRT ETLYHKEESL RGFIKSSTDD TSQIEAQIQE
3510 3520 3530 3540 3550
DWQLVVRDIY AFYPLLIKYV DLQRNHWLRN NISNAEDLYN HVSEIFNIWS
3560 3570 3580 3590 3600
KSQYFLREEQ NFISANEIDN MILIMPTATR RSAVISETSL GGSTGKKKKK
3610 3620 3630 3640 3650
HRDKKRDKEK EIQASLMVAC LKRLLPVGLN LFAGREQELV QHCKDRFLKR
3660 3670 3680 3690 3700
MPDYDVIQFV KIQLTLPDKL DPADEMSWQH YLYSKLGSKK GTTEIKPQQV
3710 3720 3730 3740 3750
DEVADRIVAM AKVLYGLHMI DHPQLQSKAI YRSVVSTQRK RAVIACFRQL
3760 3770 3780 3790 3800
SLHALTRHRA VNIFVRSFYE LWLQDENIGQ EVMIEDLTQS FEEAELKKRD
3810 3820 3830 3840 3850
KEEEEGMADP LNQMVTTFCR GAMTERSGAL QEDPLYMSYA DILAKSCGEE
3860 3870 3880 3890 3900
EEEGNNEEEG STGNGEEEGG ASIHEQEMEK QKLLFHQARL ANRGVAEMVL
3910 3920 3930 3940 3950
LHISACKGIP SEMVMKTLQL GIAVLRGGNL EIQMGMLNHL KEKKDVGFFT
3960 3970 3980 3990 4000
SVAGLMNSCS VLDLDAFERN TKAEGLGVGS EGAAGEKNMH DAEFTCTLFR
4010 4020 4030 4040 4050
FIQLTCEGHN LEWQNYLRTQ AGNTTTVNVV ICTVDYLLRL QESIMDFYWH
4060 4070 4080 4090 4100
YSSKELIDPA GKANFFKAIG VASQVFNTLS EVIQGPCTQN QQALAHSRLW
4110 4120 4130 4140 4150
DAVGGFLFLF SHMQDKLSKH SSQVDLLKEL LNLQKDMITM MLSMLEGNVV
4160 4170 4180 4190 4200
NGTIGKQMVD TLVESASNVE LILKYFDMFL KLKDLTSSAS FTEIDPNNDG
4210 4220 4230 4240 4250
WVHPKDFKEK MEQQKSYTAE EIEFMLQCCE SNHDGKIDYI GFTDQFHEPS
4260 4270 4280 4290 4300
KEIGFNLAVL LTNLSEHMPN EPRLTRFLET ASSVLNYFQP FLGRIEILGG
4310 4320 4330 4340 4350
SKRIERVYFE IKESNIEQWL KPQIRESKRA FFYSIVTEGG DKEKLEAFVN
4360 4370 4380 4390 4400
FCEDAIFEMQ HASGLMAVDD GSGIGGGKSR KTAYTYMADD EENKTAKDPI
4410 4420 4430 4440 4450
RRGIQAIKYG FHLLFFVLSP TNIKNKINEI QQMSVIELIT SFFKLWFYLI
4460 4470 4480 4490 4500
FYTGYSGVYV LRYISRILMQ LMSGTQSEET TVEVVEEKSG SFRMLPALPS
4510 4520 4530 4540 4550
SGMDEPPSTL TDGNNMRKNS GSPDSKHLKS NSVGDDKDET SAENHEKEDG
4560 4570 4580 4590 4600
VDGSEQQASF VDLLVGESAR KDSIAGPEVL AQQQAVMAAV EAEIKQKNSV
4610 4620 4630 4640 4650
ENPSAFSTID INAYTHRALS FLARNFYNLK YVALVLAFCI NFILLFYKVT
4660 4670 4680 4690 4700
TLADDLSDDG DVKEFALGSA GISNDDMDDS NSTEIADDEG VLELVHVNED
4710 4720 4730 4740 4750
FFYMAHVMRL AALLHSLASL AMLIAYYHLK VPLAIFKREK EIARRLEFDG
4760 4770 4780 4790 4800
LYIVEQPEDD DIKSHWDKLV ISAKSFPVNY WDKFAKKKVR QKYSETYDFD
4810 4820 4830 4840 4850
SISNLLGMEK TSFSTQENEE RTGLINFVIN IDWRYQVWKA GVTITDNAFL
4860 4870 4880 4890 4900
YSLWYFTFSI LGNFNNFFFA AHLLDVAVGF KTLRTILQSV THNGKQLVLT
4910 4920 4930 4940 4950
VLLLTIIVYI YTVIAFNFFR KFYVQEEDDE VDKKCHDMLT CFVFHLYKGV
4960 4970 4980 4990 5000
RAGGGIGDEI GSPDGDDYEV YRIMFDITFF FFVIIILLAI IQGLIIDAFG
5010 5020 5030 5040 5050
ELRDQLESVK EDMESNCFIC GIGKDYFDKV PHGFDTHVQE EHNLANYMFF
5060 5070 5080 5090 5100
LMHLINKPDT EYTGQETYVW NMYQQRCWDF FPVGDCFRKQ YEEELGGGGG

V
Length:5,101
Mass (Da):579,963
Last modified:May 14, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6500E487FFD8D447
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
ABLF02024172 Genomic DNA No translation available.
ABLF02024173 Genomic DNA No translation available.
ABLF02024174 Genomic DNA No translation available.

NCBI Reference Sequences

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RefSeqi
XP_016661950.1, XM_016806461.1

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
ACYPI069453-RA; ACYPI069453-PA; ACYPI069453

Database of genes from NCBI RefSeq genomes

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GeneIDi
100167965

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
api:100167965

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABLF02024172 Genomic DNA No translation available.
ABLF02024173 Genomic DNA No translation available.
ABLF02024174 Genomic DNA No translation available.
RefSeqiXP_016661950.1, XM_016806461.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7029.ACYPI069453-PA

Protein family/group databases

TCDBi1.A.3.1.7, the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family

Genome annotation databases

EnsemblMetazoaiACYPI069453-RA; ACYPI069453-PA; ACYPI069453
GeneIDi100167965
KEGGiapi:100167965

Phylogenomic databases

eggNOGiKOG2243, Eukaryota
HOGENOMiCLU_000040_2_0_1
OrthoDBi5161at2759
PhylomeDBiX1WXB1

Family and domain databases

CDDicd12877, SPRY1_RyR, 1 hit
cd12878, SPRY2_RyR, 1 hit
cd12879, SPRY3_RyR, 1 hit
Gene3Di2.60.120.920, 3 hits
InterProiView protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR013320, ConA-like_dom_sf
IPR011992, EF-hand-dom_pair
IPR014821, Ins145_P3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR013662, RIH_assoc-dom
IPR000699, RIH_dom
IPR013333, Ryan_recept
IPR003032, Ryanodine_rcpt
IPR009460, Ryanrecept_TM4-6
IPR035910, RyR/IP3R_RIH_dom_sf
IPR035761, SPRY1_RyR
IPR035764, SPRY2_RyR
IPR035762, SPRY3_RyR
IPR003877, SPRY_dom
PfamiView protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF02815, MIR, 1 hit
PF08454, RIH_assoc, 1 hit
PF06459, RR_TM4-6, 1 hit
PF01365, RYDR_ITPR, 2 hits
PF02026, RyR, 4 hits
PF00622, SPRY, 3 hits
PRINTSiPR00795, RYANODINER
SMARTiView protein in SMART
SM00472, MIR, 4 hits
SM00449, SPRY, 3 hits
SUPFAMiSSF100909, SSF100909, 1 hit
SSF47473, SSF47473, 1 hit
SSF49899, SSF49899, 3 hits
SSF82109, SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50188, B302_SPRY, 3 hits
PS50919, MIR, 5 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiX1WXB1_ACYPI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: X1WXB1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 14, 2014
Last sequence update: May 14, 2014
Last modified: June 2, 2021
This is version 48 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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