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UniProtKB - X1WXB1 (X1WXB1_ACYPI)

Entry version 50 (19 Jan 2022)
Sequence version 1 (14 May 2014)
Previous versions | rss
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Protein
Submitted name:

Uncharacterized protein

Gene

100167965

Organism
Acyrthosiphon pisum (Pea aphid)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channelARBA annotation, Ion channel, Ligand-gated ion channelARBA annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Protein family/group databases

Transport Classification Database

More...TCDBi		1.A.3.1.7, the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:100167965Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAcyrthosiphon pisum (Pea aphid)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7029 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Paraneoptera › Hemiptera › Sternorrhyncha › Aphidomorpha › Aphidoidea › Aphididae › Macrosiphini › Acyrthosiphon
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007819 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4445 – 4464HelicalSequence analysisAdd BLAST20
Transmembranei4627 – 4647HelicalSequence analysisAdd BLAST21
Transmembranei4710 – 4729HelicalSequence analysisAdd BLAST20
Transmembranei4897 – 4919HelicalSequence analysisAdd BLAST23
Transmembranei4973 – 4996HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane, Sarcoplasmic reticulumARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		7029.ACYPI069453-PA

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini95 – 149MIRInterPro annotationAdd BLAST55
Domaini577 – 802B30.2/SPRYInterPro annotationAdd BLAST226
Domaini1015 – 1215B30.2/SPRYInterPro annotationAdd BLAST201
Domaini1460 – 1683B30.2/SPRYInterPro annotationAdd BLAST224

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1352 – 1480DisorderedSequence analysisAdd BLAST129
Regioni2815 – 2836DisorderedSequence analysisAdd BLAST22
Regioni2922 – 2949DisorderedSequence analysisAdd BLAST28
Regioni3586 – 3609DisorderedSequence analysisAdd BLAST24
Regioni3847 – 3870DisorderedSequence analysisAdd BLAST24
Regioni4494 – 4555DisorderedSequence analysisAdd BLAST62

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili461 – 481Sequence analysisAdd BLAST21
Coiled coili3784 – 3804Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1376 – 1390Pro residuesSequence analysisAdd BLAST15
Compositional biasi1391 – 1405Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1406 – 1426Polar residuesSequence analysisAdd BLAST21
Compositional biasi1427 – 1478Basic and acidic residuesSequence analysisAdd BLAST52
Compositional biasi2816 – 2836Polar residuesSequence analysisAdd BLAST21
Compositional biasi2922 – 2945Polar residuesSequence analysisAdd BLAST24
Compositional biasi4504 – 4528Polar residuesSequence analysisAdd BLAST25
Compositional biasi4529 – 4553Basic and acidic residuesSequence analysisAdd BLAST25

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2243, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000040_2_0_1

Database of Orthologous Groups

More...OrthoDBi		5161at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		X1WXB1

Family and domain databases

Conserved Domains Database

More...CDDi		cd12877, SPRY1_RyR, 1 hit
cd12878, SPRY2_RyR, 1 hit
cd12879, SPRY3_RyR, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.120.920, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR013320, ConA-like_dom_sf
IPR011992, EF-hand-dom_pair
IPR014821, Ins145_P3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR013662, RIH_assoc-dom
IPR000699, RIH_dom
IPR013333, Ryan_recept
IPR003032, Ryanodine_rcpt
IPR009460, Ryanrecept_TM4-6
IPR035910, RyR/IP3R_RIH_dom_sf
IPR035761, SPRY1_RyR
IPR035764, SPRY2_RyR
IPR035762, SPRY3_RyR
IPR003877, SPRY_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF02815, MIR, 1 hit
PF08454, RIH_assoc, 1 hit
PF06459, RR_TM4-6, 1 hit
PF01365, RYDR_ITPR, 2 hits
PF02026, RyR, 4 hits
PF00622, SPRY, 3 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00795, RYANODINER

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00472, MIR, 4 hits
SM00449, SPRY, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF100909, SSF100909, 1 hit
SSF47473, SSF47473, 1 hit
SSF49899, SSF49899, 3 hits
SSF82109, SSF82109, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50188, B302_SPRY, 3 hits
PS50919, MIR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

X1WXB1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADSEGSSEQ DDVSFLRTED MVCLSCTATG ERVCLAAEGF GNRHCYLENI 
        60         70         80         90        100
ADKNIPPDLS QCVFVIEQAL SVRALQELVT AASSQEGKGG TGSGHRTLLY 
       110        120        130        140        150
GNAILLRHQN SDMYLACLST SSSNDKLSFD VGLQEHSQGE ACWWTVHPAS 
       160        170        180        190        200
KQRSEGEKVR VGDDLILVSV ATERYLHTAK ENELSVVNAS FHVTHWSVQP 
       210        220        230        240        250
YGTGISRMKY VGYVFGGDVL RFFHGGDECL TIPSSWSDVS GQNIVIYEGG 
       260        270        280        290        300
SVMSQARSLW RLELARTKWA GGFINWYHPM RIRHLTTGRY LGVNENNELH 
       310        320        330        340        350
LVCREEATTA SSTFFLRQEK DDQKIILEDK DLEVIGAPII KYGDSTVLVQ 
       360        370        380        390        400
HSDTGLWLTY KSYETKKKGV GKVEEKQAVL HEEGKMDDGL DFSRSQEEES 
       410        420        430        440        450
RTARVIRKCS SLFTQFISGL ENLQSNRRSS LFCSFVNLNE MVMCLEDLIN 
       460        470        480        490        500
YFAQPEEDME HEEKQNRFRA LRNRQDLFQE EGILNLILEA IDKVNIITSQ 
       510        520        530        540        550
GFMVSLAGDE SGQSWDVISG YLYQLLAAII KGNHTNCAQF ANTNRLNWLF 
       560        570        580        590        600
SRLGSQASSE GTGMLDVLHC VLIDSPEALN MMKDEHIKVI ISLLEKHGRD 
       610        620        630        640        650
PKVLDVLCSL CVGNGVAVRS SQNNICDFLL PGKNLLLQTL LVDHVASVRP 
       660        670        680        690        700
NIFVGHVSGS AVYRKWYYEV AIDHVEQTTH LNPHIRIGWA NTAGYVPYPG 
       710        720        730        740        750
GGEKWGGNGV GDDLYSFGFD GSYLWTGGRK SEVMPGTQIS NIKKSDVIGC 
       760        770        780        790        800
ALDLTIPIIT FTLNGQLVQG AFRDFNLDGM FFPVISCSSK VSCRFLLGGD 
       810        820        830        840        850
HGRLKFTPPD EFSPLFETLL PQQILTIDPC FYFGNLNKCV LTGPWYVEDD 
       860        870        880        890        900
TAFVPNPVDT SMVTLPSYIE NIKDKLAENI HEMWAMNKIE AGWQYGDKRN 
       910        920        930        940        950
DTRKFHPCLI QFDKLPPAEK RYDSQLAVQT LKTVIALGYH ISIDNPPSRI 
       960        970        980        990       1000
KTVRLPNEPF MQSNGYKPAP LDLSAIILSG KMEELIDQLA ENTHNLWAKE 
      1010       1020       1030       1040       1050
RIQQGWTYGL NEELQMLRSP HLVPYSKVDD AIKKANRDTA SETVRTLLVY 
      1060       1070       1080       1090       1100
GYNLDPPTGE TNEATLLTDD NTNRYLTFRT YRAEKTYAVS SGKWYFEFEI 
      1110       1120       1130       1140       1150
LTSGPMRVGW ARFTCSPGYQ IGSDENSWAF DGYNEEKIYM GTAESFGRQW 
      1160       1170       1180       1190       1200
QVGDVVGVFL DLMDHTISFS MNGELLMDTL GGETTFSEVQ GEGFVPAFTL 
      1210       1220       1230       1240       1250
GLGQKAKLTF GQDVNSLKYF TTCGLQEGYE PFCVNMKRPV TYWYTKDQPI 
      1260       1270       1280       1290       1300
FENTDDFSSV IDVTRIPAGS DTPPCLKISH NTFETMEKAN WEFLRLSLPV 
      1310       1320       1330       1340       1350
ICLPSFIDEQ EKQRRWQEIR IRQHRLLSQS EHATPAHIEQ IMKSGFSMSD 
      1360       1370       1380       1390       1400
IKGLHRGYSD DPVENDEMMP NATPLPPRGK NQPPPPRPPR KGSLSRHDDL 
      1410       1420       1430       1440       1450
TIENEGKLNR SSSELNFNIY NHQNGDGQDI NKDDKKKRGR SPFRFFSRKK 
      1460       1470       1480       1490       1500
EGPSDNPKRA KTPDPVRNVD RSRNAAHRPN TLNERVTPQI RVSQMDLKLV 
      1510       1520       1530       1540       1550
PPAIPDRPGG PKAMSFTPTS AGIEFVGNEI FDLECLKLIN EYYYGVRIFP 
      1560       1570       1580       1590       1600
GQDPTHVYVG WVTTQYHLHT KDFSQNHVRK STVTIVDEHN RILESIDRQS 
      1610       1620       1630       1640       1650
CYMVRSDELY NEVTNDSSGK GASQGMAIGC FIDIATGMMS FTCEGKETSF 
      1660       1670       1680       1690       1700
KFKMEPDIKL FPAIFVEASS KEILQIELGR TSTTLPLSAA VLQNSERHVL 
      1710       1720       1730       1740       1750
PQFPPRLKVQ CLRPHQWARV PNDSLHIHTL KLSDIRGWSI LCEDPVSMIA 
      1760       1770       1780       1790       1800
LHIPEEDRCI DILELIEMEK LLSFHAHTLT LYAAVCYQAN YRAAHILCTH 
      1810       1820       1830       1840       1850
VNQKQLLYAI CSEYMSGPLR QGFYDLLIAL HLESHATTME VCKNEYIIPL 
      1860       1870       1880       1890       1900
GHELTTLYDD PQMGHSLRSL QTESVRPQMK MTEISDVIDN VRNLYSPYFP 
      1910       1920       1930       1940       1950
LQVVREYVMA ALEEAVLVNQ VHNRDPIGGS NENLFLPLLK LVDRLLLVGM 
      1960       1970       1980       1990       2000
LRDEDVEKLL IMINPETWDP EFQKDGPDEH RKGLLHMKMA EGAKLQMCYL 
      2010       2020       2030       2040       2050
LHHLCDIQLR HRVESIISFS YQFVNDIQID QLRRYNEIKQ SDLPSAVAAK 
      2060       2070       2080       2090       2100
KTREFRCPPR EQMNAILGFK NLDSDDKENC LIGDDLRERM NEFNEKLMKQ 
      2110       2120       2130       2140       2150
ISLVALQESE DDKSDLNNLN NEGKIKQFYN FINAVKDEGN EDGLNEQEKK 
      2160       2170       2180       2190       2200
IPEEIFRKVL ISTIVSWAEE TQIETPKLVR EMFSLLVRQY DSVGELIRAL 
      2210       2220       2230       2240       2250
EKTYVINFKT KEDVAQMWVG LSQIRSLLPV QMSQEEEELM RERLWKLVNN 
      2260       2270       2280       2290       2300
HTFFQHPDLI RVLRMHENVM AVMMNTLGRR AQAQSQPGGT PVTGQDGEIV 
      2310       2320       2330       2340       2350
PKEKDTSHEM VVACCRFLCY FCRTSRQNQK AMFDHFSFLL ENSNILLSRP 
      2360       2370       2380       2390       2400
SLRGSTPLDV AYSSLMENTE LALALREHYL EKIAIYLSRC GLQSNSELIE 
      2410       2420       2430       2440       2450
KGYPDLGWDP VEGERYLDFL RFCVWVNGES VEENANLVIR LLIRRPECLG 
      2460       2470       2480       2490       2500
PALRGEGEGL LRAIIDANKM SERITERRKF LEESGNQENI QLDHPLPESD 
      2510       2520       2530       2540       2550
EDEDYIDTGA AILNFYCTLV DLLGRCAPDS SVISLGKNES LRARAILRSL 
      2560       2570       2580       2590       2600
VPLEDLHGVL SLRFTLQNPA AGQDRPKSDM PSGLIPGHKQ SVVLFLERVY 
      2610       2620       2630       2640       2650
GIEMQELFFT LLEEAFLPDL RTATMLDRND GLESDMALAM NRYIGNSVLP 
      2660       2670       2680       2690       2700
LLIGHSKFYS ESDNYANLLD ATLHTVYRLS KNRMLTKGQR EAVSDFLVAL 
      2710       2720       2730       2740       2750
TSQMQPSMLL KLLRKLTVDV SNLSEYTTVA LRLLTLHYDR CAKYYGSTGG 
      2760       2770       2780       2790       2800
QGIYGASSDE EKRLTMMLFS NIFDSLSKMD YDPELFGKAL PCLSAIGCAL 
      2810       2820       2830       2840       2850
PPDYSLSKNH DDEWYGSKQN IQGPSDGPYN PQPINTNSIV LDNDLNSIVH 
      2860       2870       2880       2890       2900
KFSEHYHDAW ANRKLENGWV YGEQFNDVNK SHPRLKPYMM LSEYEKELYK 
      2910       2920       2930       2940       2950
EPVRESLKAL LAIGWSIEHS ENDAPLNNRG SVRRQSKSNE NVTPFDYHPN 
      2960       2970       2980       2990       3000
PIDMTNLTLT REMQNMAERL AENSHDIWAK KKKEEVMLCG GGIHNQLVPY 
      3010       3020       3030       3040       3050
DLLTDKEKKK DRERSQEFLK YLQYQGYKLH RPNRNGGPSE AEQLAAASTG 
      3060       3070       3080       3090       3100
ELRFSYSLLE KLIHYIDRAS INMKLLKPSG TFSRRSSFKI CTRDIKFFSK 
      3110       3120       3130       3140       3150
VVLPLVEKYF STHRNYFITV ATASSVLGAA SLKEKEMVAS LFCKLANLLR 
      3160       3170       3180       3190       3200
SKLMAFGADV RITVRCLQVL VKAIDAKSLV KNCPEFIRTS MLTFFHNIAD 
      3210       3220       3230       3240       3250
DLEHTIQNLH DSRYCYLRGT HLKTSTSLFY VNDVILPVLS SLFDHLAAYE 
      3260       3270       3280       3290       3300
YGNELLLNEI QVAAYKMLSS LYTLGTDTSL THDRKYLKVQ LERHRPAFGS 
      3310       3320       3330       3340       3350
CLGAFSSTFP VAFLEPHLNK HNQYSLLNRF ADSSLEAQDI MSRMEGTMPT 
      3360       3370       3380       3390       3400
LETVLNEVDQ FIESEKTYAD APHIIDVILP LLCSYLPYWW AQGPDNVALT 
      3410       3420       3430       3440       3450
TGNHVTMVTS EHMNCLLKNV LKLIKKNIGN DNAPWMTQIA AYTQQIIINS 
      3460       3470       3480       3490       3500
SEELLKDPFL PLAERVKKRT ETLYHKEESL RGFIKSSTDD TSQIEAQIQE 
      3510       3520       3530       3540       3550
DWQLVVRDIY AFYPLLIKYV DLQRNHWLRN NISNAEDLYN HVSEIFNIWS 
      3560       3570       3580       3590       3600
KSQYFLREEQ NFISANEIDN MILIMPTATR RSAVISETSL GGSTGKKKKK 
      3610       3620       3630       3640       3650
HRDKKRDKEK EIQASLMVAC LKRLLPVGLN LFAGREQELV QHCKDRFLKR 
      3660       3670       3680       3690       3700
MPDYDVIQFV KIQLTLPDKL DPADEMSWQH YLYSKLGSKK GTTEIKPQQV 
      3710       3720       3730       3740       3750
DEVADRIVAM AKVLYGLHMI DHPQLQSKAI YRSVVSTQRK RAVIACFRQL 
      3760       3770       3780       3790       3800
SLHALTRHRA VNIFVRSFYE LWLQDENIGQ EVMIEDLTQS FEEAELKKRD 
      3810       3820       3830       3840       3850
KEEEEGMADP LNQMVTTFCR GAMTERSGAL QEDPLYMSYA DILAKSCGEE 
      3860       3870       3880       3890       3900
EEEGNNEEEG STGNGEEEGG ASIHEQEMEK QKLLFHQARL ANRGVAEMVL 
      3910       3920       3930       3940       3950
LHISACKGIP SEMVMKTLQL GIAVLRGGNL EIQMGMLNHL KEKKDVGFFT 
      3960       3970       3980       3990       4000
SVAGLMNSCS VLDLDAFERN TKAEGLGVGS EGAAGEKNMH DAEFTCTLFR 
      4010       4020       4030       4040       4050
FIQLTCEGHN LEWQNYLRTQ AGNTTTVNVV ICTVDYLLRL QESIMDFYWH 
      4060       4070       4080       4090       4100
YSSKELIDPA GKANFFKAIG VASQVFNTLS EVIQGPCTQN QQALAHSRLW 
      4110       4120       4130       4140       4150
DAVGGFLFLF SHMQDKLSKH SSQVDLLKEL LNLQKDMITM MLSMLEGNVV 
      4160       4170       4180       4190       4200
NGTIGKQMVD TLVESASNVE LILKYFDMFL KLKDLTSSAS FTEIDPNNDG 
      4210       4220       4230       4240       4250
WVHPKDFKEK MEQQKSYTAE EIEFMLQCCE SNHDGKIDYI GFTDQFHEPS 
      4260       4270       4280       4290       4300
KEIGFNLAVL LTNLSEHMPN EPRLTRFLET ASSVLNYFQP FLGRIEILGG 
      4310       4320       4330       4340       4350
SKRIERVYFE IKESNIEQWL KPQIRESKRA FFYSIVTEGG DKEKLEAFVN 
      4360       4370       4380       4390       4400
FCEDAIFEMQ HASGLMAVDD GSGIGGGKSR KTAYTYMADD EENKTAKDPI 
      4410       4420       4430       4440       4450
RRGIQAIKYG FHLLFFVLSP TNIKNKINEI QQMSVIELIT SFFKLWFYLI 
      4460       4470       4480       4490       4500
FYTGYSGVYV LRYISRILMQ LMSGTQSEET TVEVVEEKSG SFRMLPALPS 
      4510       4520       4530       4540       4550
SGMDEPPSTL TDGNNMRKNS GSPDSKHLKS NSVGDDKDET SAENHEKEDG 
      4560       4570       4580       4590       4600
VDGSEQQASF VDLLVGESAR KDSIAGPEVL AQQQAVMAAV EAEIKQKNSV 
      4610       4620       4630       4640       4650
ENPSAFSTID INAYTHRALS FLARNFYNLK YVALVLAFCI NFILLFYKVT 
      4660       4670       4680       4690       4700
TLADDLSDDG DVKEFALGSA GISNDDMDDS NSTEIADDEG VLELVHVNED 
      4710       4720       4730       4740       4750
FFYMAHVMRL AALLHSLASL AMLIAYYHLK VPLAIFKREK EIARRLEFDG 
      4760       4770       4780       4790       4800
LYIVEQPEDD DIKSHWDKLV ISAKSFPVNY WDKFAKKKVR QKYSETYDFD 
      4810       4820       4830       4840       4850
SISNLLGMEK TSFSTQENEE RTGLINFVIN IDWRYQVWKA GVTITDNAFL 
      4860       4870       4880       4890       4900
YSLWYFTFSI LGNFNNFFFA AHLLDVAVGF KTLRTILQSV THNGKQLVLT 
      4910       4920       4930       4940       4950
VLLLTIIVYI YTVIAFNFFR KFYVQEEDDE VDKKCHDMLT CFVFHLYKGV 
      4960       4970       4980       4990       5000
RAGGGIGDEI GSPDGDDYEV YRIMFDITFF FFVIIILLAI IQGLIIDAFG 
      5010       5020       5030       5040       5050
ELRDQLESVK EDMESNCFIC GIGKDYFDKV PHGFDTHVQE EHNLANYMFF 
      5060       5070       5080       5090       5100
LMHLINKPDT EYTGQETYVW NMYQQRCWDF FPVGDCFRKQ YEEELGGGGG 

V
Length:5,101
Mass (Da):579,963
Last modified:May 14, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6500E487FFD8D447
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
ABLF02024172 Genomic DNA No translation available.
ABLF02024173 Genomic DNA No translation available.
ABLF02024174 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		XP_016661950.1, XM_016806461.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		ACYPI069453-RA; ACYPI069453-PA; ACYPI069453

Database of genes from NCBI RefSeq genomes

More...GeneIDi		100167965

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		api:100167965

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABLF02024172 Genomic DNA No translation available.
ABLF02024173 Genomic DNA No translation available.
ABLF02024174 Genomic DNA No translation available.
RefSeqiXP_016661950.1, XM_016806461.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi7029.ACYPI069453-PA

Protein family/group databases

TCDBi1.A.3.1.7, the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family

Genome annotation databases

EnsemblMetazoaiACYPI069453-RA; ACYPI069453-PA; ACYPI069453
GeneIDi100167965
KEGGiapi:100167965

Phylogenomic databases

eggNOGiKOG2243, Eukaryota
HOGENOMiCLU_000040_2_0_1
OrthoDBi5161at2759
PhylomeDBiX1WXB1

Family and domain databases

CDDicd12877, SPRY1_RyR, 1 hit
cd12878, SPRY2_RyR, 1 hit
cd12879, SPRY3_RyR, 1 hit
Gene3Di2.60.120.920, 3 hits
InterProiView protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR013320, ConA-like_dom_sf
IPR011992, EF-hand-dom_pair
IPR014821, Ins145_P3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR013662, RIH_assoc-dom
IPR000699, RIH_dom
IPR013333, Ryan_recept
IPR003032, Ryanodine_rcpt
IPR009460, Ryanrecept_TM4-6
IPR035910, RyR/IP3R_RIH_dom_sf
IPR035761, SPRY1_RyR
IPR035764, SPRY2_RyR
IPR035762, SPRY3_RyR
IPR003877, SPRY_dom
PfamiView protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF02815, MIR, 1 hit
PF08454, RIH_assoc, 1 hit
PF06459, RR_TM4-6, 1 hit
PF01365, RYDR_ITPR, 2 hits
PF02026, RyR, 4 hits
PF00622, SPRY, 3 hits
PRINTSiPR00795, RYANODINER
SMARTiView protein in SMART
SM00472, MIR, 4 hits
SM00449, SPRY, 3 hits
SUPFAMiSSF100909, SSF100909, 1 hit
SSF47473, SSF47473, 1 hit
SSF49899, SSF49899, 3 hits
SSF82109, SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50188, B302_SPRY, 3 hits
PS50919, MIR, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiX1WXB1_ACYPI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: X1WXB1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 14, 2014
Last sequence update: May 14, 2014
Last modified: January 19, 2022
This is version 50 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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