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Entry version 24 (11 Dec 2019)
Sequence version 1 (14 May 2014)
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Protein

DUF1758 domain-containing protein

Gene
N/A
Organism
Acyrthosiphon pisum (Pea aphid)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DUF1758 domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAcyrthosiphon pisum (Pea aphid)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7029 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraHemipteraSternorrhynchaAphidomorphaAphidoideaAphididaeMacrosiphiniAcyrthosiphon
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007819 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini434 – 586DUF1758InterPro annotationAdd BLAST153

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni290 – 320DisorderedSequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi299 – 320PolarSequence analysisAdd BLAST22

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
222689at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005312 DUF1759
IPR008737 Peptidase_asp_put
IPR008042 Retrotrans_Pao

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05585 DUF1758, 1 hit
PF03564 DUF1759, 1 hit
PF05380 Peptidase_A17, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

X1WRA3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTTSYSDAK SRVLRCITKL KSFAQASIDY NNDRTNSGKR AKIAKMISEL
60 70 80 90 100
TPLRNAIEDD VQRMESAVNS KTAPEDITDN SESQALITSF DGFYYELAAF
110 120 130 140 150
ADVHITQLPK RSFPTFSGVM TEWQSFDDLF NSILSHAPEL PDVERFEFLK
160 170 180 190 200
MSLKGEALSL VSHLALTATN YSSAWKILRS RYGNKRDLAR IHLDALLANQ
210 220 230 240 250
KVKANDGTSI QTQINTILEN TAALDNLDFV TRQWSPLLVH VVEKHLDYEL
260 270 280 290 300
RARWELVVGD NHYPQISEFV DFLRTHLRSA EIYSTCTSVD RSDSVSKPHK
310 320 330 340 350
SAKQPNFKPR SSSTVLATTS SHSPVKPCPL CNAPHSIRLC KKFTDKPPNE
360 370 380 390 400
RFNIAKTHRL CINCLGFGHS SMSCTSKYKC QLCKRSHHSL LHFDATTAAT
410 420 430 440 450
TSSDYVPSGS VPHAATCLVR GLPQSVVLLS TALVDVYAAD GRRHVLRALL
460 470 480 490 500
DCGSQASFIT EKACCALMLR RYHSPVNVST FASTVSTCIR GKCSINIVPC
510 520 530 540 550
GLQAPSVSTD VSIISKITGP TPQSPLITGQ WTHIQNLPLA DPSYNIPGAI
560 570 580 590 600
DLLLGADLLP SIYLDGLQRG LVGEPIAMNT IFGWVLLGPM DSCDRSSITT
610 620 630 640 650
MCLTISEPLD SLLKQFWELE ELPITCHLSP ADLAAEQLYQ STTTRLSSGR
660 670 680 690 700
FVVSLPFLKP LPLLGDSKTL ALQRFKALEF RLNRNNTLKT QYAEFMRDYL
710 720 730 740 750
TAGHMELIPP AEHGNPYHYY IPHHCVIKPD SLTTKLRVVF NASAKTSAGI
760 770 780 790 800
SLNESMYTGP KLQPDIQRVL LRARLWKYLF MADIKQMYRQ ILVRPEDRDY
810 820 830 840 850
LRILWRFSST SPIDEYRLCT VTYGTSAAPF QALRTVRELA SVDGASWPIA
860 870 880 890 900
ASVLLNDTFV DDILTGANTT EAALECQSQL INLCAMARFQ LRKWASNNTQ
910 920 930 940 950
LLETVADDAR AMSPSVLFDS SEHSNLKVLG LKWDPLADTF SFKVHPSKVH
960 970 980 990 1000
PTKRTVLSDI ARVFDPLGLM SPITFWTKYL MQRLWTSGVS WDDPIPADIE
1010 1020 1030 1040 1050
TSWSRYQSEL HLIEHIPIPR RLTWDNMVSM QLHAFSDSSE KGYAAAIYLR
1060 1070 1080 1090 1100
VETTTEIHCQ LITGKSKVAP LKKTTIPRLE LCGAVLAAKL LKSVTTTYNE
1110 1120 1130 1140 1150
RMKIDETYAW TDSTTALAWI QSSPHRWATF VANRASQIQE LTAPSIWHYV
1160 1170 1180 1190 1200
PTQENPVDCA SRGLFPSELV NHPLWWTGPA FLKESSDKWP TLSVPQLNDH
1210 1220 1230 1240 1250
NPLTHSEAKK ATVLLVNAEV SLVRLLTRFS SLDKILRIVS YIYRFVGFRP
1260 1270 1280 1290 1300
STATTAIVSA EEFVRALHGL IRGVQQEIFL DDLTRLKRGD RCSKTLRPLD
1310 1320 1330
PFIDENGLLR VGGRLHNAEI PYDHKHPILL PSRH
Length:1,334
Mass (Da):149,455
Last modified:May 14, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE9E5ECF50571D39C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
ABLF02066034 Genomic DNA No translation available.

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
ACYPI064834-RA; ACYPI064834-PA; ACYPI064834

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABLF02066034 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblMetazoaiACYPI064834-RA; ACYPI064834-PA; ACYPI064834

Phylogenomic databases

OrthoDBi222689at2759

Family and domain databases

InterProiView protein in InterPro
IPR005312 DUF1759
IPR008737 Peptidase_asp_put
IPR008042 Retrotrans_Pao
PfamiView protein in Pfam
PF05585 DUF1758, 1 hit
PF03564 DUF1759, 1 hit
PF05380 Peptidase_A17, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiX1WRA3_ACYPI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: X1WRA3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 14, 2014
Last sequence update: May 14, 2014
Last modified: December 11, 2019
This is version 24 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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