UniProtKB - X1WD95 (X1WD95_DANRE)
Protein
Carbonic anhydrase
Gene
ca12
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Reversible hydration of carbon dioxide.UniRule annotation
Catalytic activityi
- EC:4.2.1.1UniRule annotation
Cofactori
Zn2+UniRule annotation
GO - Molecular functioni
- carbonate dehydratase activity Source: GO_Central
- hydro-lyase activity Source: GO_Central
- zinc ion binding Source: UniProtKB-UniRule
GO - Biological processi
- one-carbon metabolic process Source: GO_Central
Keywordsi
Molecular function | LyaseUniRule annotation |
Ligand | Metal-bindingUniRule annotationARBA annotation, ZincUniRule annotationARBA annotation |
Enzyme and pathway databases
Reactomei | R-DRE-1475029, Reversible hydration of carbon dioxide |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ca12Imported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-080815-4, ca12 |
Subcellular locationi
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 203 – 231 | HelicalSequence analysisAdd BLAST | 29 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSDARG00000045644, Expressed in muscle organ and 17 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 186 | Alpha-carbonic anhydraseInterPro annotationAdd BLAST | 186 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000159282 |
Family and domain databases
Gene3Di | 3.10.200.10, 1 hit |
InterProi | View protein in InterPro IPR001148, CA_dom IPR036398, CA_dom_sf IPR023561, Carbonic_anhydrase_a-class IPR018338, Carbonic_anhydrase_a-class_CS IPR018430, Carbonic_anhydrase_CA12 |
PANTHERi | PTHR18952, PTHR18952, 1 hit PTHR18952:SF19, PTHR18952:SF19, 1 hit |
Pfami | View protein in Pfam PF00194, Carb_anhydrase, 1 hit |
SMARTi | View protein in SMART SM01057, Carb_anhydrase, 1 hit |
SUPFAMi | SSF51069, SSF51069, 1 hit |
PROSITEi | View protein in PROSITE PS00162, ALPHA_CA_1, 1 hit PS51144, ALPHA_CA_2, 1 hit |
i Sequence
Sequence statusi: Complete.
X1WD95-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYISSLPHRY SAAQLHFHWG SSNLLTGSEH TVNGKQFAGE MHVVHFNSDK
60 70 80 90 100
YPNVSMAVDK HDGLAVLGVF IEIGEANPAF DKLFRFISGV KYRDQKIQVP
110 120 130 140 150
AFNIRALLPD RLDQYYRYDG SLTTPPCYPS VLWTVFRKPV TISRKQFLAL
160 170 180 190 200
ATALYASFAQ DSPSMPLHEN YRKSQLPDNR VVLVSFREEL LHHNICLSGD
210 220 230 240 250
FTWMSWGIIA SITAASMLGL LMIITLVWCI LRKRSYTEEQ EEKNNGCKLS
EKEEHIS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR391977 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSDART00000157235; ENSDARP00000128192; ENSDARG00000045644 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR391977 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSDART00000157235; ENSDARP00000128192; ENSDARG00000045644 |
Organism-specific databases
ZFINi | ZDB-GENE-080815-4, ca12 |
Phylogenomic databases
GeneTreei | ENSGT00940000159282 |
Enzyme and pathway databases
Reactomei | R-DRE-1475029, Reversible hydration of carbon dioxide |
Gene expression databases
Bgeei | ENSDARG00000045644, Expressed in muscle organ and 17 other tissues |
Family and domain databases
Gene3Di | 3.10.200.10, 1 hit |
InterProi | View protein in InterPro IPR001148, CA_dom IPR036398, CA_dom_sf IPR023561, Carbonic_anhydrase_a-class IPR018338, Carbonic_anhydrase_a-class_CS IPR018430, Carbonic_anhydrase_CA12 |
PANTHERi | PTHR18952, PTHR18952, 1 hit PTHR18952:SF19, PTHR18952:SF19, 1 hit |
Pfami | View protein in Pfam PF00194, Carb_anhydrase, 1 hit |
SMARTi | View protein in SMART SM01057, Carb_anhydrase, 1 hit |
SUPFAMi | SSF51069, SSF51069, 1 hit |
PROSITEi | View protein in PROSITE PS00162, ALPHA_CA_1, 1 hit PS51144, ALPHA_CA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | X1WD95_DANRE | |
Accessioni | X1WD95Primary (citable) accession number: X1WD95 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 14, 2014 |
Last sequence update: | May 14, 2014 | |
Last modified: | October 7, 2020 | |
This is version 35 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |