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Entry version 40 (02 Jun 2021)
Sequence version 1 (14 May 2014)
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Protein
Submitted name:

Si:dkey-1f12.3

Gene

eml5

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.

ARBA annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • microtubule binding Source: GO_Central

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Si:dkey-1f12.3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:eml5Imported
Synonyms:si:dkey-1f12.3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-030131-1677, eml5

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
X1WCH2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000053517, Expressed in retina and 14 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
X1WCH2, baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000127915

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini57 – 488WD_REPEATS_REGIONInterPro annotationAdd BLAST432
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati250 – 265WDPROSITE-ProRule annotationAdd BLAST16
Repeati330 – 362WDPROSITE-ProRule annotationAdd BLAST33
Repeati404 – 435WDPROSITE-ProRule annotationAdd BLAST32
Domaini723 – 1117WD_REPEATS_REGIONInterPro annotationAdd BLAST395
Repeati896 – 926WDPROSITE-ProRule annotationAdd BLAST31
Domaini1231 – 1273WD_REPEATS_REGIONInterPro annotationAdd BLAST43
Repeati1231 – 1273WDPROSITE-ProRule annotationAdd BLAST43
Domaini1422 – 1550WD_REPEATS_REGIONInterPro annotationAdd BLAST129
Domaini1690 – 1814WD_REPEATS_REGIONInterPro annotationAdd BLAST125
Repeati1697 – 1731WDPROSITE-ProRule annotationAdd BLAST35
Repeati1773 – 1814WDPROSITE-ProRule annotationAdd BLAST42

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni607 – 634DisorderedSequence analysisAdd BLAST28
Regioni1315 – 1355DisorderedSequence analysisAdd BLAST41

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat EMAP family.ARBA annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

RepeatARBA annotation, WD repeatPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2106, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156613

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001930_0_0_1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 6 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024977, Apc4_WD40_dom
IPR005108, HELP
IPR011047, Quinoprotein_ADH-like_supfam
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12894, ANAPC4_WD40, 2 hits
PF03451, HELP, 3 hits
PF00400, WD40, 10 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320, WD40, 29 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978, SSF50978, 3 hits
SSF50998, SSF50998, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00678, WD_REPEATS_1, 1 hit
PS50082, WD_REPEATS_2, 7 hits
PS50294, WD_REPEATS_REGION, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

X1WCH2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADRTAPNCH LRLEWVYGYR GHQCRNNLYY TAAKEIVYFV AGVGVVYNTR
60 70 80 90 100
EHKQKFYLGH NDDIISLALH PERVLVATGQ VGKEPYICVW DSYTVQTVSI
110 120 130 140 150
LRDMHTHGIA CLAFDLDGQC LVSVGLDSKN TICVWDWRQG KVLAAAPGHT
160 170 180 190 200
DRIFDISWDL YQQSKLVSCG VKHIKFWSLC GNALTPKRGV FGKTGDLQTI
210 220 230 240 250
LCLACARDEI TYSGALNGDI YVWKGINLIR TVQGAHGSGI FSMNACEEGF
260 270 280 290 300
ATGGRDGCIR LWDLNFKPIT VIDLRETDQG YKGLSVRSVC WRGDHILVGT
310 320 330 340 350
QDSEIFEVVV HDRTKPFLIM QGHCEGELWA LAVHPTKPLA MTGSDDRSVR
360 370 380 390 400
IWSLVDHALI ARCNMEEPIR CAAVSTDGIH LALGMKDGSF TVLRVRDMTE
410 420 430 440 450
VVHIKDRKEA IHELKYSPDG AHLAVGSNDN SVDIYGVVQR YKKVGECVGS
460 470 480 490 500
SSFITHMDWS TDSKYLQTND GNGRRLFYRM PSGKEVTNRE ELKLVQWSSW
510 520 530 540 550
TCVLGPEVNG IWPKYSDIND INSVDANFSS QVLVTADDYG LVKLFRYPCI
560 570 580 590 600
RKGAKFKKYL GHSAHITNIR WSHDYQWVIT IGGADHSVFQ WKFVPERKSK
610 620 630 640 650
DTLHIAPQET LIDSHSEESD SDQSDVPEMD SEIEQETQLT YRRQVYKEDL
660 670 680 690 700
PQLKEQCKEK HRAMAMKKRE RAPASGMRLH FIHGYRGYDC RSNLFYTQTG
710 720 730 740 750
EIVYHVAAVG VVYNRQQNTQ RFYLGHDDDI LCLAIHPVKD YVATGQVGRD
760 770 780 790 800
SSIHIWETEF LKPLSVLKGF HQFGVCALDF SADGKRLASV GLDDNHTIVL
810 820 830 840 850
WEWRKGEKLS TIRGSKDKIF VIKINPYMPD KLISAGVKHM KFWHRAGGGL
860 870 880 890 900
IGKKGSMGKT ETMMCAVYGW TEEMVFSGTC TGDICIWRDM FLVKTVKAHD
910 920 930 940 950
GPVFSMHALE KGFVTGGKDG IVALWDDTFE RCLKTYAIKR AVLAPGSKGL
960 970 980 990 1000
LLEDNPSIRA ISLGHGHILV GTKNGEILEV DKNGPITLLV QGHMEGEVWG
1010 1020 1030 1040 1050
LATHPHLPLC ATVSDDKTLR IWDLSPSHCM LAVRKLKKGG RCCCFSPDGK
1060 1070 1080 1090 1100
ALAVGLNDGS FLIVNADTLE DLVSFHHRKD IISEIRFSPV TGKYLAVASG
1110 1120 1130 1140 1150
DSFVDIYNVM SSKRVGVCKG SMNYITHLDW DKRGKLLQVN TSAKEQLFFE
1160 1170 1180 1190 1200
APRGKKQSIP VTEVEKIDWS TWTCVLGSSC EGIWPVVSEV TEVTAACLSY
1210 1220 1230 1240 1250
DKKLLATGDD LGYVKLFKYP VKGKYAKFKR YMAHSTHVTN VRWSHDDSLL
1260 1270 1280 1290 1300
ASVGGSDTCL MIWNHETESC REARQCDSEE SDIESEDDGG YDSDVTRENE
1310 1320 1330 1340 1350
IVYVIKALST NMRPMTGVKP HLQQKEPTVD ERGSRPPVSR APPMPEKLQT
1360 1370 1380 1390 1400
NNVGKKKRPI EDLVLELVFG YRGNDCRNNV HYLNEGADII YHTASIGVVL
1410 1420 1430 1440 1450
NLTTACQSFY LEHSDDILCL TINQHPKFPN VVATGQVGDT GDMSATSPSI
1460 1470 1480 1490 1500
HVWEAMNKQT LSVLRCHHSR GVCSVSFSAT GKLLLSVGLD PQHTLTIWKW
1510 1520 1530 1540 1550
QEGAKVASRA GHTQRIFVAE FRPDSDTQFV SVGIKHVRFW TLAGRALLSK
1560 1570 1580 1590 1600
KGVLSSIEDA RMQTMLSVAF GANNLTFTGT ISGDVCVWKE HILVRIVAKA
1610 1620 1630 1640 1650
HTGPVFTMYT TLRDGLIVTG GKERPSKEGG ALKLWDQELK RCRAFRLETG
1660 1670 1680 1690 1700
QVIDCVRSVC RGKGKILVGT RNAEIIEVGE KNAACNILVN GHMDGPVWGL
1710 1720 1730 1740 1750
GAHPTRDVFL SAAEDGTVRL WDISQRKMLN KVNLGHPART VSYSPEGDMV
1760 1770 1780 1790 1800
AIGMKNGEFI ILLVTSLKIW GKKRDRRSAI QDIRFSPDSR YLAVGSSENA
1810 1820 1830 1840 1850
VDFYDLTLGP QLNRINCCRD IPSFVMQMDF SADSCFVQLS TGAYKRVVYE
1860 1870 1880 1890 1900
VPSGKQVTEQ AVIDRITWAT WTSVLGDEVV GIWSRNTDKA DVTCACVSHS
1910 1920 1930 1940 1950
GINIVTGDDF GMVKLFDFPC PEKFAKHKRF LGHSAHLTNV RFTNGDRFVV
1960
SAGGDDRSLF VWRCVHTPH
Length:1,969
Mass (Da):219,886
Last modified:May 14, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBB53806F89A3E808
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286Y8K5A0A286Y8K5_DANRE
Si:dkey-1f12.3
eml5 si:dkey-1f12.3
1,332Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR759765 Genomic DNA No translation available.
CR936467 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000156885; ENSDARP00000127915; ENSDARG00000053517

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR759765 Genomic DNA No translation available.
CR936467 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000127915

Proteomic databases

PaxDbiX1WCH2

Genome annotation databases

EnsembliENSDART00000156885; ENSDARP00000127915; ENSDARG00000053517

Organism-specific databases

ZFINiZDB-GENE-030131-1677, eml5

Phylogenomic databases

eggNOGiKOG2106, Eukaryota
GeneTreeiENSGT00940000156613
HOGENOMiCLU_001930_0_0_1

Gene expression databases

BgeeiENSDARG00000053517, Expressed in retina and 14 other tissues
ExpressionAtlasiX1WCH2, baseline

Family and domain databases

Gene3Di2.130.10.10, 6 hits
InterProiView protein in InterPro
IPR024977, Apc4_WD40_dom
IPR005108, HELP
IPR011047, Quinoprotein_ADH-like_supfam
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12894, ANAPC4_WD40, 2 hits
PF03451, HELP, 3 hits
PF00400, WD40, 10 hits
SMARTiView protein in SMART
SM00320, WD40, 29 hits
SUPFAMiSSF50978, SSF50978, 3 hits
SSF50998, SSF50998, 2 hits
PROSITEiView protein in PROSITE
PS00678, WD_REPEATS_1, 1 hit
PS50082, WD_REPEATS_2, 7 hits
PS50294, WD_REPEATS_REGION, 5 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiX1WCH2_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: X1WCH2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 14, 2014
Last sequence update: May 14, 2014
Last modified: June 2, 2021
This is version 40 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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