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UniProtKB - X1WBG3 (X1WBG3_DANRE)

Entry version 17 (07 Oct 2020)
Sequence version 1 (20 Jun 2018)
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Protein
Submitted name:

Tau tubulin kinase 1b

Gene

ttbk1b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Tau tubulin kinase 1bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ttbk1bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Zebrafish Information Network genome database

More...ZFINi		ZDB-GENE-100609-5, ttbk1b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		X1WBG3, baseline

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini34 – 297Protein kinaseInterPro annotationAdd BLAST264

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni307 – 332DisorderedSequence analysisAdd BLAST26
Regioni366 – 394DisorderedSequence analysisAdd BLAST29
Regioni409 – 521DisorderedSequence analysisAdd BLAST113
Regioni542 – 647DisorderedSequence analysisAdd BLAST106
Regioni671 – 693DisorderedSequence analysisAdd BLAST23
Regioni718 – 753DisorderedSequence analysisAdd BLAST36
Regioni818 – 1048DisorderedSequence analysisAdd BLAST231
Regioni1089 – 1219DisorderedSequence analysisAdd BLAST131

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi315 – 332PolarSequence analysisAdd BLAST18
Compositional biasi437 – 473PolyampholyteSequence analysisAdd BLAST37
Compositional biasi561 – 585PolyampholyteSequence analysisAdd BLAST25
Compositional biasi677 – 691PolarSequence analysisAdd BLAST15
Compositional biasi818 – 869PolyampholyteSequence analysisAdd BLAST52
Compositional biasi893 – 951PolyampholyteSequence analysisAdd BLAST59
Compositional biasi963 – 977PolarSequence analysisAdd BLAST15
Compositional biasi978 – 1001PolyampholyteSequence analysisAdd BLAST24
Compositional biasi1003 – 1019PolarSequence analysisAdd BLAST17
Compositional biasi1020 – 1037PolyampholyteSequence analysisAdd BLAST18
Compositional biasi1100 – 1114Pro-richSequence analysisAdd BLAST15
Compositional biasi1115 – 1200PolarSequence analysisAdd BLAST86
Compositional biasi1203 – 1219PolyampholyteSequence analysisAdd BLAST17

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000165311

KEGG Orthology (KO)

More...KOi		K08815

Identification of Orthologs from Complete Genome Data

More...OMAi		NSLPNGP

Family and domain databases

Conserved Domains Database

More...CDDi		cd14130, STKc_TTBK1, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR042714, TTBK1_STKc

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

X1WBG3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQCVGPGVHG DENMNGAGEQ VDILPSNCLV KDRWKVLKKI GGGGFGEIYE 
        60         70         80         90        100
AYDLLTRENV ALKVESAQQP KQVLKMEVAV LKKLQGKNHV CKFIGCGRND 
       110        120        130        140        150
KFNYVVMQLQ GRNLADLRRS QPRGTFSMST TLRLGKQILE SIEAIHSVGF 
       160        170        180        190        200
LHRDIKPSNF AMGRLPSTCR KCYMLDFGLA RQYTNTNGEV RPPRSVAGFR 
       210        220        230        240        250
GTVRYASINA HKNKEMGRHD DLWSLFYMLV EFTVGQLPWR KIKDKEQVGQ 
       260        270        280        290        300
IKERYEHRML LKHMPAEFHI FYDHVLDLDY FTKPDYQLLM SVFENSMKDR 
       310        320        330        340        350
VITENEPYDW EKSGTDTALP TSTHTPPQQN TRQTAAIVGV VNVTPVPGEL 
       360        370        380        390        400
PRENTDDVLQ DEHLSDQENA PPALIPSRPS EPAPAAPAGE AWDETDFNRN 
       410        420        430        440        450
QLRISISKTQ VAAEDGDEPA GGGRSVSPAR GGEGDAQARP PRYRRVNSPE 
       460        470        480        490        500
SERLSGAEDR GDGADKRSRL DMLGSPSRHV YSSQPAQMLS LEGGQGERLA 
       510        520        530        540        550
GGRHDVSADG DQEAHSNAFI RSVPLAEEED FDSREWVMID KETELKDFLP 
       560        570        580        590        600
GAEPTTSGTT DEEPEELRPL EDHEERRRRV HGGAEAVVRP KTQRGMMIVA 
       610        620        630        640        650
EEEGAGPSPG HSSCHTLPRS CPRRRESEPF GPDGPDIAVA EPSPSFSQTR 
       660        670        680        690        700
MKRVDFVSGV LMFDDLREEV VKTGGSGSDG SPRSSEGSPE GAASTLLAPA 
       710        720        730        740        750
HRDHDQEEGS RTLVLVSAGN GQVSPGDGQG TLAALTPQGE RPVPEESEPG 
       760        770        780        790        800
TLSSVIKSEP RPIVMTTAAV ITSGSSSPPF TKVERTFIHI AETSHLNVMT 
       810        820        830        840        850
ARHRPSGFDE PISVEREEMG EEKEDRAGQL VEIERNSEGI KVEREGDEKK 
       860        870        880        890        900
KEESEAEKEK QEVENVIISS REEAETVFLA EQPVSIAIKE NISIETKLDD 
       910        920        930        940        950
EQDGVTTEKE QEQEESPSVS PEQNRDAEVE DEKDVSPPEV ESPDRKPLPQ 
       960        970        980        990       1000
RRSRIPVLMS EDETGSDKSS QTSQEQLQRT RKSRHQQLAR LVLERKQTHM 
      1010       1020       1030       1040       1050
MRSRSASSHS PTLSTTASED EAHQSDDSAK GADGKIKSRI PRPVTPIRGS 
      1060       1070       1080       1090       1100
YDLLKCTTLP QTQRSVSFIQ YRTNSSINPK IQKSASLHTN IHQQPPKPQL 
      1110       1120       1130       1140       1150
RPSKTLPPLP PSSGPSHTQG SRTATRTVTR TSAPNATRSI STSPRSYGTS 
      1160       1170       1180       1190       1200
RTDSPSPQRI RRQLAANETQ RQAQQPRPPV PSVSKSKPQD STTPRKSKSH 
      1210 
PSTSTKAKKD PLESKTKTR
Length:1,219
Mass (Da):134,844
Last modified:June 20, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDA8FBC8AE7B73558
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7FBX6E7FBX6_DANRE
Tau tubulin kinase 1b
ttbk1b
671Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X1WH52X1WH52_DANRE
Tau tubulin kinase 1b
ttbk1b
243Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BX649523 Genomic DNA No translation available.
CT027715 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		XP_017207296.1, XM_017351807.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSDART00000156872; ENSDARP00000127554; ENSDARG00000056659

Database of genes from NCBI RefSeq genomes

More...GeneIDi		100000353

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dre:100000353

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX649523 Genomic DNA No translation available.
CT027715 Genomic DNA No translation available.
RefSeqiXP_017207296.1, XM_017351807.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

EnsembliENSDART00000156872; ENSDARP00000127554; ENSDARG00000056659
GeneIDi100000353
KEGGidre:100000353

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		100000353
ZFINiZDB-GENE-100609-5, ttbk1b

Phylogenomic databases

GeneTreeiENSGT00940000165311
KOiK08815
OMAiNSLPNGP

Gene expression databases

ExpressionAtlasiX1WBG3, baseline

Family and domain databases

CDDicd14130, STKc_TTBK1, 1 hit
InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR042714, TTBK1_STKc
PfamiView protein in Pfam
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiX1WBG3_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: X1WBG3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 20, 2018
Last sequence update: June 20, 2018
Last modified: October 7, 2020
This is version 17 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
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