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Entry version 37 (11 Dec 2019)
Sequence version 1 (14 May 2014)
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Protein

Cellulose synthase

Gene

L484_015857

Organism
Morus notabilis
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions per subunit.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: plant cellulose biosynthesis

This protein is involved in the pathway plant cellulose biosynthesis, which is part of Glycan metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway plant cellulose biosynthesis and in Glycan metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferaseUniRule annotationSAAS annotation, Transferase
Biological processCell wall biogenesis/degradationUniRule annotationSAAS annotation, Cellulose biosynthesisUniRule annotation, Transcription, Transcription regulationSAAS annotation
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00695

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cellulose synthaseUniRule annotation (EC:2.4.1.12UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:L484_015857Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMorus notabilisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri981085 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsfabidsRosalesMoraceaeMorus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000030645 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei734 – 751HelicalUniRule annotationAdd BLAST18
Transmembranei763 – 782HelicalUniRule annotationAdd BLAST20
Transmembranei1330 – 1356HelicalUniRule annotationAdd BLAST27
Transmembranei1376 – 1398HelicalUniRule annotationAdd BLAST23
Transmembranei1419 – 1440HelicalUniRule annotationAdd BLAST22
Transmembranei1460 – 1478HelicalUniRule annotationAdd BLAST19
Transmembranei1490 – 1510HelicalUniRule annotationAdd BLAST21

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane, NucleusSAAS annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
981085.XP_010091789.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini264 – 324HTH myb-typeInterPro annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni230 – 270DisorderedSequence analysisAdd BLAST41
Regioni402 – 484DisorderedSequence analysisAdd BLAST83
Regioni600 – 652DisorderedSequence analysisAdd BLAST53

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili355 – 375Sequence analysisAdd BLAST21
Coiled coili914 – 934Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi230 – 267PolarSequence analysisAdd BLAST38
Compositional biasi402 – 424PolarSequence analysisAdd BLAST23
Compositional biasi429 – 446PolyampholyteSequence analysisAdd BLAST18
Compositional biasi453 – 480PolyampholyteSequence analysisAdd BLAST28
Compositional biasi616 – 632PolyampholyteSequence analysisAdd BLAST17
Compositional biasi633 – 652PolarSequence analysisAdd BLAST20

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyltransferase 2 family. Plant cellulose synthase subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation, Zinc-fingerUniRule annotation

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
679241at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit
3.90.550.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005150 Cellulose_synth
IPR027934 CES_Znf_RING
IPR009057 Homeobox-like_sf
IPR025756 Myb_CC_LHEQLE
IPR017930 Myb_dom
IPR006447 Myb_dom_plants
IPR029044 Nucleotide-diphossugar_trans
IPR001005 SANT/Myb
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03552 Cellulose_synt, 1 hit
PF14379 Myb_CC_LHEQLE, 1 hit
PF00249 Myb_DNA-binding, 1 hit
PF14569 zf-UDP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689 SSF46689, 1 hit
SSF53448 SSF53448, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01557 myb_SHAQKYF, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51294 HTH_MYB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

W9RB71-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEARPALSIP RSGTTQLTNM GVSGAFTSSL PVLPTPYEES YPKLPDSQQV
60 70 80 90 100
SIERELMTSP LTHASHLTSN SGVMGHIFSS SSGFSSDLHY SSVSLSQQKI
110 120 130 140 150
QSRNTPFIPQ SSTNGVSFSV PQSSYSTLLH STTSSHYTKE NSASWCTDSV
160 170 180 190 200
EDLLDFSVNT PVENSQVESS SCSGIVASDE FGRRNDWQDW ADQLITDNNA
210 220 230 240 250
LNSSWDEFLA DTNVAEMEPK MAYQVEKPPS FQAQHPQLHQ QHSAPSGEIQ
260 270 280 290 300
TVATPSCSTN SATASAKPRM RWTPELHEAF VEAVNQLGGS ERATPKGVLK
310 320 330 340 350
LMKVESLTIY HVKSHLQKYR TARYRPESSE GSSEKRLTPI DEISSLDLKT
360 370 380 390 400
GIEITEALRL QMEVQKRLHE QLEIQRNLQL RIEEQGRYLQ IMFEKQKSGM
410 420 430 440 450
DKLKASSSTL GNPSAVSSDA IQGSPEKGEQ EASKIDDGKT ENDSSDAKTT
460 470 480 490 500
TRGGSDELGE QKEAPQGKVP DNHEPDVCET DPTPSHITTS SFASLHQPCF
510 520 530 540 550
LHITFFAFAM AGFVTGSHTR NDLQVSDAEQ NSRPLTRQAA SRICRVCGDE
560 570 580 590 600
IGYKENGDLF VACHVCGFPV CRPCYDYERS DGNQSCPQCN TRYRRHKGCP
610 620 630 640 650
RVAGDDDDSD DGDDFDDEFR MKNHHSDNSD DHRINPLTNN SDNGEHNQQQ
660 670 680 690 700
WQPNGHAFSV AGSAAKEFEG EKEVYGNDEW KDRVEKWKVR QERRGNLLNK
710 720 730 740 750
DDGNNDQGDD EDYLLAEARQ PLWRKIPIPS SLISPYRIVI VLRLLILCFF
760 770 780 790 800
FRFRILTPAY DAFPLWLISV ICEIWFAFSW ILDQFPKWCP VTRQTYLDRL
810 820 830 840 850
SIRFERDGEP NRLSPVDVYV STVDPLKEPP IITANTVLSI LSVDYPVDKV
860 870 880 890 900
CCYVSDDGAS MLLFDSLAET AEFARRWVPF CKKHNIEPRT PEFYFSEKID
910 920 930 940 950
YLKDKVHPSF VKERRAMKRE YEEFKVRINA LVAKAQKKPE DGWVMQDGTP
960 970 980 990 1000
WPGNNTRDHP GMIQVYLGSG GALDVEGKEL PRLVYISREK RPGYQHHKKA
1010 1020 1030 1040 1050
GAMNALVRVS AVLSNAPFML NLDCDHYINN SKALREAMCF LMDPQLGKKL
1060 1070 1080 1090 1100
CYVQFPQRFD GIDLHDRYAN RNTVFFDINM KGLDGIQGPV YVGTGTVFNR
1110 1120 1130 1140 1150
QALYGYDPPV SEKRPKMTCD CWPSWCCCCC GSSRKSKSKK KGLASLLGGL
1160 1170 1180 1190 1200
YTKKKKMMGK NYVRKGSGAM FDLEEIEEGL EGYEELEKSS LMSQKNFEKR
1210 1220 1230 1240 1250
FGQSPVFIAS TLMEDGGLPE GTNSTTLIKE AIHVISCGYE EKTEWGKEIG
1260 1270 1280 1290 1300
WIYGSVTEDI LTGFKMHCRG WKSVYCIPKR PAFKGSAPIN LSDRLHQVLR
1310 1320 1330 1340 1350
WALGSVEIFL SRHCPLWYGY GGKLKLLERL AYINTILNNL ASVWFLALFL
1360 1370 1380 1390 1400
SIIATGVLEL RWSGVSLEDW WRNEQFWVIG GVSAHLFAVF QGLLKVLAGV
1410 1420 1430 1440 1450
DTNFTVTAKA ADDAEFGELY LFKWTTLLIP PTTLIILNMV GVVAGISDAI
1460 1470 1480 1490 1500
NNGYGSWGPL FGKLFFSFWV ILHLYPFLKG LMGRQNRTPT IVVLWSILLA
1510 1520
SIFSLVWVRI DPFLPKQTGP ILKQCGVEC
Length:1,529
Mass (Da):171,984
Last modified:May 14, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD4682473A67E7483
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KE343920 Genomic DNA Translation: EXB45997.1

NCBI Reference Sequences

More...
RefSeqi
XP_010091789.1, XM_010093487.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KE343920 Genomic DNA Translation: EXB45997.1
RefSeqiXP_010091789.1, XM_010093487.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi981085.XP_010091789.1

Phylogenomic databases

OrthoDBi679241at2759

Enzyme and pathway databases

UniPathwayiUPA00695

Family and domain databases

Gene3Di3.30.40.10, 1 hit
3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR005150 Cellulose_synth
IPR027934 CES_Znf_RING
IPR009057 Homeobox-like_sf
IPR025756 Myb_CC_LHEQLE
IPR017930 Myb_dom
IPR006447 Myb_dom_plants
IPR029044 Nucleotide-diphossugar_trans
IPR001005 SANT/Myb
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF03552 Cellulose_synt, 1 hit
PF14379 Myb_CC_LHEQLE, 1 hit
PF00249 Myb_DNA-binding, 1 hit
PF14569 zf-UDP, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR01557 myb_SHAQKYF, 1 hit
PROSITEiView protein in PROSITE
PS51294 HTH_MYB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiW9RB71_9ROSA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: W9RB71
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 14, 2014
Last sequence update: May 14, 2014
Last modified: December 11, 2019
This is version 37 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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