UniProtKB - W8W3P5 (W8W3P5_HUMAN)
Protein
Submitted name:
MAS-related GPR, member X1
Gene
MGRG2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
Keywordsi
Molecular function | G-protein coupled receptorUniRule annotation, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Submitted name: MAS-related GPR, member X1ImportedSubmitted name: Mas-related G protein-coupled receptor G2Imported |
Gene namesi | Name:MGRG2Imported Synonyms:MRGPRX1Imported ORF Names:hCG_1991280Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000170255.7 |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 28 – 52 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 64 – 85 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 97 – 117 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 138 – 166 | HelicalSequence analysisAdd BLAST | 29 | |
Transmembranei | 178 – 202 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 214 – 242 | HelicalSequence analysisAdd BLAST | 29 | |
Transmembranei | 254 – 275 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000170255, Expressed in sural nerve and 13 other tissues |
ExpressionAtlasi | W8W3P5, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 44 – 272 | G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST | 229 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
HOGENOMi | CLU_009579_4_1_1 |
OMAi | PFGIQFF |
OrthoDBi | 1123658at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR026234, MRGPCRFAMILY IPR027338, MRGPCRX1 |
PANTHERi | PTHR11334, PTHR11334, 1 hit PTHR11334:SF22, PTHR11334:SF22, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR02108, MRGPCRFAMILY |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
W8W3P5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDPTISTLDT ELTPINGTEE TLCYKQTLSL TVLTCIVSLV GLTGNAVVLW
60 70 80 90 100
LLGCRMRRNA FSIYILNLAA ADFLFLSGRL IYSLLSFISI PHTISKILYP
110 120 130 140 150
VMMFSYFAGL SFLSAVSTER CLSVLWPIWY RCHRPTHLSA VVCVLLWALS
160 170 180 190 200
LLRSILEWML CGFLFSGADS AWCQTSDFIT VAWLIFLCVV LCGSSLVLLI
210 220 230 240 250
RILCGSRKIP LTRLYVTILL TVLVFLLCGL PFGIQFFLFL WIHVDREVLF
260 270 280 290 300
CHVHLVSIFL SALNSSANPI IYFFVGSFRQ RQNRQNLKLV LQRALQDASE
310 320
VDEGGGQLPE EILELSGSRL EQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HG426070 Genomic DNA Translation: CDG86188.1 CH471064 Genomic DNA Translation: EAW68360.1 |
RefSeqi | NP_671732.3, NM_147199.3 |
Genome annotation databases
GeneIDi | 259249 |
KEGGi | hsa:259249 |
UCSCi | uc001mpg.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HG426070 Genomic DNA Translation: CDG86188.1 CH471064 Genomic DNA Translation: EAW68360.1 |
RefSeqi | NP_671732.3, NM_147199.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Chemistry databases
BindingDBi | W8W3P5 |
Protein family/group databases
GPCRDBi | Search... |
Protocols and materials databases
Antibodypediai | 25195, 120 antibodies |
Genome annotation databases
GeneIDi | 259249 |
KEGGi | hsa:259249 |
UCSCi | uc001mpg.3, human |
Organism-specific databases
CTDi | 259249 |
EuPathDBi | HostDB:ENSG00000170255.7 |
Phylogenomic databases
HOGENOMi | CLU_009579_4_1_1 |
OMAi | PFGIQFF |
OrthoDBi | 1123658at2759 |
Miscellaneous databases
BioGRID-ORCSi | 259249, 9 hits in 836 CRISPR screens |
GenomeRNAii | 259249 |
Gene expression databases
Bgeei | ENSG00000170255, Expressed in sural nerve and 13 other tissues |
ExpressionAtlasi | W8W3P5, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR026234, MRGPCRFAMILY IPR027338, MRGPCRX1 |
PANTHERi | PTHR11334, PTHR11334, 1 hit PTHR11334:SF22, PTHR11334:SF22, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR02108, MRGPCRFAMILY |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | W8W3P5_HUMAN | |
Accessioni | W8W3P5Primary (citable) accession number: W8W3P5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 14, 2014 |
Last sequence update: | May 14, 2014 | |
Last modified: | December 2, 2020 | |
This is version 46 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |