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Protein

Adenylate cyclase

Gene

cyaA

Organism
Escherichia coli
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationImported
Biological processcAMP biosynthesisUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate cyclaseUniRule annotation (EC:4.6.1.1UniRule annotation)
Gene namesi
Name:cyaAImported
ORF Names:A8C65_11025Imported, A9R57_05905Imported, AM266_12170Imported, AM464_12320Imported, APT13_16000Imported, AUQ13_19780Imported, BHS87_21320Imported, BJJ90_26125Imported, BUE81_11295Imported, C9E25_10325Imported, CA593_06955Imported, DTL43_17320Imported, EC1094V2_4502Imported, EC3234A_71c00080Imported, ERS085365_02082Imported, ERS085416_02742Imported, ERS139211_01519Imported, ERS150873_02254Imported, NCTC9037_05010Imported, NCTC9045_05779Imported, NCTC9060_03521Imported, NCTC9062_03216Imported, NCTC9110_04678Imported, NCTC9117_06204Imported, NCTC9706_02197Imported, PGD_00164Imported, RK56_018330Imported, SAMEA3472044_03833Imported, SAMEA3472047_02767Imported, SAMEA3472067_04778Imported, SAMEA3472080_03827Imported, SAMEA3484427_04048Imported, SAMEA3484429_03951Imported, SAMEA3484433_04732Imported, SAMEA3752557_03848Imported, SAMEA3752559_04167Imported, SAMEA3753097_03601Imported, SAMEA3753106_02114Imported, SAMEA3753397_04226Imported, SK85_04135Imported
OrganismiEscherichia coliImported
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi

Subcellular locationi

GO - Cellular componenti

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 200Adenyl_cycl_NInterPro annotationAdd BLAST196

Sequence similaritiesi

Belongs to the adenylyl cyclase class-1 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107T0K Bacteria
COG3072 LUCA

Family and domain databases

InterProiView protein in InterPro
IPR000274 Adenylate_cyclase_1
IPR024686 Adenylate_cyclase_1_CS
IPR024685 Adenylate_cyclase_1_N
PANTHERiPTHR38760 PTHR38760, 1 hit
PfamiView protein in Pfam
PF12633 Adenyl_cycl_N, 1 hit
PF01295 Adenylate_cycl, 1 hit
PIRSFiPIRSF001444 Adenylate_cycl, 1 hit
PROSITEiView protein in PROSITE
PS01092 ADENYLATE_CYCLASE_1_1, 1 hit
PS01093 ADENYLATE_CYCLASE_1_2, 1 hit

Sequencei

Sequence statusi: Complete.

W8T0H1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYLYIETLKQ RLDAINQLRV DRALAAMGPA FQQVYSLLPT LLHYHHPLMP
60 70 80 90 100
GYLDGNVPKG ICLYTPDETQ RHYLNELELY RGMSVQDPPK GELPITGVYT
110 120 130 140 150
MGSTSSVGQS CSSDLDIWVC HQSWLDSEER QLLQRKCSLL ENWAASLGVE
160 170 180 190 200
VSFFLIDENR FRHNESGSLG GEDCGSTQHI LLLDEFYRTA VRLAGKRILW
210 220 230 240 250
NMVPCDEEEH YDDYVMTLYA QGVLTPNEWL DLGGLSSLSA EEYFGASLWQ
260 270 280 290 300
LYKSIDSPYK AVLKTLLLEA YSWEYPNPRL LAKDIKQRLH DGEIVSFGLD
310 320 330 340 350
PYCMMLERVT EYLTAIEDFT RLDLVRRCFY LKVCEKLSRE RACVGWRRAV
360 370 380 390 400
LSQLVSEWGW DEARLAMLDN RANWKIDQVR EAHNELLDAM MQSYRNLIRF
410 420 430 440 450
ARRNNLSVSA SPQDIGVLTR KLYAAFEALP GKVTLVNPQI SPDLSEPNLT
460 470 480 490 500
FIYVPPGRAN RSGWYLYNRA PNIESIISHQ PLEYNRYLNK LVAWAWFNGL
510 520 530 540 550
LTSRTRLYIK GNGIVDLPKL QEMVADVSHH FPLRLPAPTP KALYSPCEIR
560 570 580 590 600
HLAIIVNLEY DPTAAFRNQV VHFDFRKLDV FSFGENQNCL VGSVDLLYRN
610 620 630 640 650
SWNEVRTLHF NGEQSMIEAL KTILGKMHQD AAPPDSVEVF CYSQHLRGLI
660 670 680 690 700
RTRVQQLVSE CIELRLSSTR QETGRFKALR VSGQTWGLFF ERLNVSVQKL
710 720 730 740 750
ENAIEFYGAI SHNKLHGLSV QVETNHVKLP AVVDGFASEG IIQFFFEETQ
760 770 780 790 800
DENGFNIYIL DESNRVEVYH HCEGSKEELV RDVSRFYSSS HDRFTYGSSF
810 820 830 840
INFNLPQFYQ IVKVDGREQV IPFRTKSIGN MPPANQDHDT PLLQQYFS
Length:848
Mass (Da):97,586
Last modified:May 14, 2014 - v1
Checksum:iF0400E3406B15018
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017631 Genomic DNA Translation: APT05214.1
CP021175 Genomic DNA Translation: ARR32864.1
CP029741 Genomic DNA Translation: AWS63614.1
HG976957 Genomic DNA Translation: CDU40117.1
CYAQ01000015 Genomic DNA Translation: CTS59827.1
CYDH01000013 Genomic DNA Translation: CTV63416.1
CYCX01000020 Genomic DNA Translation: CTW17069.1
CYFX01000012 Genomic DNA Translation: CTZ43021.1
LEUM01000022 Genomic DNA Translation: KLX92268.1
LIVE01000017 Genomic DNA Translation: KQJ15457.1
LOOZ01000028 Genomic DNA Translation: KXR88352.1
LCVH01000071 Genomic DNA Translation: OAC40349.1
LZEH01000079 Genomic DNA Translation: OEI66041.1
MSEK01000073 Genomic DNA Translation: OLR87310.1
NAFT01000078 Genomic DNA Translation: ORS98903.1
LYBG01000608 Genomic DNA Translation: OWD70631.1
JWSO02000014 Genomic DNA Translation: PNO95967.1
PYRW01000013 Genomic DNA Translation: PSZ84587.1
QOWX01000018 Genomic DNA Translation: RCR56626.1
QOGZ01000020 Genomic DNA Translation: RDA36448.1
LT883142 Genomic DNA Translation: SMZ47594.1
UCTY01000027 Genomic DNA Translation: SQJ64662.1
UCUN01000022 Genomic DNA Translation: SQK33135.1
UCZA01000025 Genomic DNA Translation: SQP84738.1
UCZZ01000025 Genomic DNA Translation: SQR04733.1
UDAQ01000013 Genomic DNA Translation: SQR65576.1
UDDW01000024 Genomic DNA Translation: SQY03609.1
UDGC01000024 Genomic DNA Translation: SQY43678.1
UDGL01000023 Genomic DNA Translation: SQZ13933.1
UFYM01000003 Genomic DNA Translation: STD60977.1
UGBV01000003 Genomic DNA Translation: STH77911.1
UGCZ01000001 Genomic DNA Translation: STJ41483.1
UGDD01000002 Genomic DNA Translation: STJ57724.1
UGDG01000002 Genomic DNA Translation: STJ71500.1
UGDC01000003 Genomic DNA Translation: STJ83534.1
UGGJ01000004 Genomic DNA Translation: STN85133.1
UINI01000027 Genomic DNA Translation: SVF34141.1
UINO01000027 Genomic DNA Translation: SVF35037.1
UINP01000026 Genomic DNA Translation: SVF45171.1
UINX01000022 Genomic DNA Translation: SVF97191.1
RefSeqiWP_000281668.1, NZ_UIKT01000014.1

Genome annotation databases

EnsemblBacteriaiAOT35163; AOT35163; FORC31_4713
CDU40117; CDU40117; PGD_00164
CTS59827; CTS59827; ERS085365_02082
CTV63416; CTV63416; ERS139211_01519
CTW17069; CTW17069; ERS085416_02742
CTZ43021; CTZ43021; ERS150873_02254
KLX92268; KLX92268; SK85_04135
KQJ15457; KQJ15457; AM266_12170
KXQ43111; KXQ43111; AUQ01_00230
OAC40349; OAC40349; EC3234A_71c00080
ODH29268; ODH29268; A6803_14830
OEI66041; OEI66041; A9R57_05905
PATRICifig|562.10472.peg.3452

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017631 Genomic DNA Translation: APT05214.1
CP021175 Genomic DNA Translation: ARR32864.1
CP029741 Genomic DNA Translation: AWS63614.1
HG976957 Genomic DNA Translation: CDU40117.1
CYAQ01000015 Genomic DNA Translation: CTS59827.1
CYDH01000013 Genomic DNA Translation: CTV63416.1
CYCX01000020 Genomic DNA Translation: CTW17069.1
CYFX01000012 Genomic DNA Translation: CTZ43021.1
LEUM01000022 Genomic DNA Translation: KLX92268.1
LIVE01000017 Genomic DNA Translation: KQJ15457.1
LOOZ01000028 Genomic DNA Translation: KXR88352.1
LCVH01000071 Genomic DNA Translation: OAC40349.1
LZEH01000079 Genomic DNA Translation: OEI66041.1
MSEK01000073 Genomic DNA Translation: OLR87310.1
NAFT01000078 Genomic DNA Translation: ORS98903.1
LYBG01000608 Genomic DNA Translation: OWD70631.1
JWSO02000014 Genomic DNA Translation: PNO95967.1
PYRW01000013 Genomic DNA Translation: PSZ84587.1
QOWX01000018 Genomic DNA Translation: RCR56626.1
QOGZ01000020 Genomic DNA Translation: RDA36448.1
LT883142 Genomic DNA Translation: SMZ47594.1
UCTY01000027 Genomic DNA Translation: SQJ64662.1
UCUN01000022 Genomic DNA Translation: SQK33135.1
UCZA01000025 Genomic DNA Translation: SQP84738.1
UCZZ01000025 Genomic DNA Translation: SQR04733.1
UDAQ01000013 Genomic DNA Translation: SQR65576.1
UDDW01000024 Genomic DNA Translation: SQY03609.1
UDGC01000024 Genomic DNA Translation: SQY43678.1
UDGL01000023 Genomic DNA Translation: SQZ13933.1
UFYM01000003 Genomic DNA Translation: STD60977.1
UGBV01000003 Genomic DNA Translation: STH77911.1
UGCZ01000001 Genomic DNA Translation: STJ41483.1
UGDD01000002 Genomic DNA Translation: STJ57724.1
UGDG01000002 Genomic DNA Translation: STJ71500.1
UGDC01000003 Genomic DNA Translation: STJ83534.1
UGGJ01000004 Genomic DNA Translation: STN85133.1
UINI01000027 Genomic DNA Translation: SVF34141.1
UINO01000027 Genomic DNA Translation: SVF35037.1
UINP01000026 Genomic DNA Translation: SVF45171.1
UINX01000022 Genomic DNA Translation: SVF97191.1
RefSeqiWP_000281668.1, NZ_UIKT01000014.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAOT35163; AOT35163; FORC31_4713
CDU40117; CDU40117; PGD_00164
CTS59827; CTS59827; ERS085365_02082
CTV63416; CTV63416; ERS139211_01519
CTW17069; CTW17069; ERS085416_02742
CTZ43021; CTZ43021; ERS150873_02254
KLX92268; KLX92268; SK85_04135
KQJ15457; KQJ15457; AM266_12170
KXQ43111; KXQ43111; AUQ01_00230
OAC40349; OAC40349; EC3234A_71c00080
ODH29268; ODH29268; A6803_14830
OEI66041; OEI66041; A9R57_05905
PATRICifig|562.10472.peg.3452

Phylogenomic databases

eggNOGiENOG4107T0K Bacteria
COG3072 LUCA

Family and domain databases

InterProiView protein in InterPro
IPR000274 Adenylate_cyclase_1
IPR024686 Adenylate_cyclase_1_CS
IPR024685 Adenylate_cyclase_1_N
PANTHERiPTHR38760 PTHR38760, 1 hit
PfamiView protein in Pfam
PF12633 Adenyl_cycl_N, 1 hit
PF01295 Adenylate_cycl, 1 hit
PIRSFiPIRSF001444 Adenylate_cycl, 1 hit
PROSITEiView protein in PROSITE
PS01092 ADENYLATE_CYCLASE_1_1, 1 hit
PS01093 ADENYLATE_CYCLASE_1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiW8T0H1_ECOLX
AccessioniPrimary (citable) accession number: W8T0H1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 14, 2014
Last sequence update: May 14, 2014
Last modified: November 7, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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