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UniProtKB - W8PHN8 (W8PHN8_DROME)

Entry version 57 (29 Sep 2021)
Sequence version 1 (14 May 2014)
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Protein
Submitted name:

GH23684p1

Gene

sav-RA

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
GH23684p1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sav-RAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		VectorBase:FBgn0053193

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0053193, Expressed in saliva-secreting gland and 34 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		W8PHN8, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		W8PHN8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini423 – 456WWInterPro annotationAdd BLAST34
Domaini458 – 491WWInterPro annotationAdd BLAST34
Domaini552 – 599SARAHInterPro annotationAdd BLAST48

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni17 – 37DisorderedSequence analysisAdd BLAST21
Regioni64 – 145DisorderedSequence analysisAdd BLAST82
Regioni157 – 202DisorderedSequence analysisAdd BLAST46
Regioni220 – 243DisorderedSequence analysisAdd BLAST24
Regioni264 – 293DisorderedSequence analysisAdd BLAST30
Regioni345 – 425DisorderedSequence analysisAdd BLAST81

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi17 – 35Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi64 – 112Polar residuesSequence analysisAdd BLAST49
Compositional biasi157 – 192Polar residuesSequence analysisAdd BLAST36
Compositional biasi227 – 243Polar residuesSequence analysisAdd BLAST17
Compositional biasi360 – 389Polar residuesSequence analysisAdd BLAST30
Compositional biasi406 – 420Polar residuesSequence analysisAdd BLAST15

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156106

Identification of Orthologs from Complete Genome Data

More...OMAi		NVWTSDQ

Database of Orthologous Groups

More...OrthoDBi		284488at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		W8PHN8

Family and domain databases

Conserved Domains Database

More...CDDi		cd00201, WW, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011524, SARAH_dom
IPR030030, Sav
IPR001202, WW_dom
IPR036020, WW_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR47522, PTHR47522, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00397, WW, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00456, WW, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51045, SSF51045, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50951, SARAH, 1 hit
PS50020, WW_DOMAIN_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

W8PHN8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNYLTILLCN RKPTMLSRRN KEKSQHKEGV VGKYMKKDTP PDISVINVWS 
        60         70         80         90        100
DQRAKKKSLQ RCASTSPSCE FHPRSSSTSR NTYSCTDSQP DYYHARRAQS 
       110        120        130        140        150
QMPLQQHSHS HPHSLPHPSH PHVRSHPPLP PHQFRASSNQ LSQNSSNYVN 
       160        170        180        190        200
FEQIERMRRQ QSSPLLQTTS SPAPGAGGFQ RSYSTTQRQH HPHLGGDSYD 
       210        220        230        240        250
ADQGLLSASY ANMLQLPQRP HSPAHYAVPP QQQQHPQIHQ QHASTPFGST 
       260        270        280        290        300
LRFDRAAMSI RERQPRYQPT SSPMQQQQQQ QQQQQQQLQH TQLAAHLGGS 
       310        320        330        340        350
YSSDSYPIYE NPSRVISMRA TQSQRSESPI YSNTTASSAT LAVVPQHHHQ 
       360        370        380        390        400
GHLAVPSGSG GGSLSGSGRG GSSGSVRGAS TSVQSLYVPP RTPPSAVAGA 
       410        420        430        440        450
GGSANGSLQK VPSQQSLTEP EELPLPPGWA TQYTLHGRKY YIDHNAHTTH 
       460        470        480        490        500
WNHPLEREGL PVGWRRVVSK MHGTYYENQY TGQSQRQHPC LTSYYVYTTS 
       510        520        530        540        550
AEPPKAIRPE ASLYAPPTHT HNALVPANPY LLEEIPKWLA VYSEADSSKD 
       560        570        580        590        600
HLLQFNMFSL PELEGFDSML VRLFKQELGT IVGFYERYRR ALILEKNRRA 

GQNQNQNQ
Length:608
Mass (Da):68,146
Last modified:May 14, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i05DF47686EE3335E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BT150435 mRNA Translation: AHL21639.1

NCBI Reference Sequences

More...RefSeqi		NP_788721.1, NM_176544.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0084356; FBpp0083749; FBgn0053193

Database of genes from NCBI RefSeq genomes

More...GeneIDi		252554

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG33193

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT150435 mRNA Translation: AHL21639.1
RefSeqiNP_788721.1, NM_176544.3

3D structure databases

SMRiW8PHN8
ModBaseiSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0084356; FBpp0083749; FBgn0053193
GeneIDi252554
KEGGidme:Dmel_CG33193

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		252554
VEuPathDBiVectorBase:FBgn0053193

Phylogenomic databases

GeneTreeiENSGT00940000156106
OMAiNVWTSDQ
OrthoDBi284488at2759
PhylomeDBiW8PHN8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		252554, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		252554

Gene expression databases

BgeeiFBgn0053193, Expressed in saliva-secreting gland and 34 other tissues
ExpressionAtlasiW8PHN8, baseline and differential

Family and domain databases

CDDicd00201, WW, 1 hit
InterProiView protein in InterPro
IPR011524, SARAH_dom
IPR030030, Sav
IPR001202, WW_dom
IPR036020, WW_dom_sf
PANTHERiPTHR47522, PTHR47522, 1 hit
PfamiView protein in Pfam
PF00397, WW, 1 hit
SMARTiView protein in SMART
SM00456, WW, 2 hits
SUPFAMiSSF51045, SSF51045, 2 hits
PROSITEiView protein in PROSITE
PS50951, SARAH, 1 hit
PS50020, WW_DOMAIN_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiW8PHN8_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: W8PHN8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 14, 2014
Last sequence update: May 14, 2014
Last modified: September 29, 2021
This is version 57 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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