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Protein

Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3

Gene

Lrit3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required in retinal ON-bipolar cells for normal localization of the cation channel TRPM1 at dendrite tips (PubMed:25997951). May also have a role in cone synapse formation (PubMed:25997951). Might facilitate FGFR1 exit from the endoplasmic reticulum to the Golgi (By similarity). Could be a regulator of the FGFRs (By similarity).By similarity1 Publication

GO - Biological processi

  • regulation of fibroblast growth factor receptor signaling pathway Source: MGI
  • response to stimulus Source: UniProtKB-KW
  • visual perception Source: MGI

Keywordsi

Biological processSensory transduction, Vision

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3Curated
Gene namesi
Name:Lrit3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2685267 Lrit3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 584LumenalCuratedAdd BLAST565
Transmembranei585 – 605HelicalSequence analysisAdd BLAST21
Topological domaini606 – 681CytoplasmicCuratedAdd BLAST76

Keywords - Cellular componenti

Cell projection, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Disruption phenotypei

Viable. Retinal anatomy is grossly normal, although thickness of the INL is reduced. In addition thickness of the innermost region consisting of the inner plexiform layer, ganglion cell layer and optic nerve fiber layer (IPL, GCL, NFL), is reduced. Optomotor responses in dim conditions are impaired. Electroretinography shows completely absent b-wave response under dim conditions, and milder abnormalities under bright conditions.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_500721808720 – 681Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3Sequence analysisAdd BLAST662

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi18N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi275 ↔ 328PROSITE-ProRule annotation
Glycosylationi296N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi485N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi506N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiW8DXL4

PTM databases

PhosphoSitePlusiW8DXL4

Expressioni

Tissue specificityi

Detected in the outer plexiform layer (OPL) of the retina, where it localizes to rod and cone ON-bipolar cells (at protein level). Also detected in bipolar cell bodies in the inner retinal layer (INL) (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000093865 Expressed in 8 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiW8DXL4 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliW8DXL4
SMRiW8DXL4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati56 – 79LRR 1Sequence analysisAdd BLAST24
Repeati80 – 103LRR 2Sequence analysisAdd BLAST24
Repeati104 – 128LRR 3Sequence analysisAdd BLAST25
Repeati129 – 151LRR 4Sequence analysisAdd BLAST23
Repeati152 – 175LRR 5Sequence analysisAdd BLAST24
Domaini254 – 344Ig-likePROSITE-ProRule annotationAdd BLAST91

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
KOG3510 Eukaryota
ENOG4110XFB LUCA
GeneTreeiENSGT00920000149011
OrthoDBiEOG091G0ACR

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 2 hits
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 2 hits
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00369 LRR_TYP, 4 hits
SUPFAMiSSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

W8DXL4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWLSACLCLV LSFLGGVNGT CPSQCSCEYH GRHDGSGSRL VLCNDLDMNE
60 70 80 90 100
VPANFPVDTS KLRIEKTVVR RLPAEAFYYL VELQYLWLAY NSVASIETSS
110 120 130 140 150
FYNLRQLHEL RLDGNSLTAF PWVSLLDMPH LRTLDLHNNR IASVPNEAVR
160 170 180 190 200
YLRNLTCLDL SSNRLTTLPP DFLDSWSHLA VTPSRSPDFP PRRIILGLQD
210 220 230 240 250
NPWFCDCHIS KVIELSKVTD HAVVLLDPLM VCSEPERFQG ILFQRVELEK
260 270 280 290 300
CLKPSVMMSA TKITSALGSN VLLRCDAKGH PTPQLTWTRS DGSTVNYTVI
310 320 330 340 350
QESPGEGIRW SIISLTSISH KDAGDYRCKA KNLAGISEAV VTVTVVGGVT
360 370 380 390 400
TTLSPDSSER SPGEPPEQHP QPGLGGSTPP SKSWLSPGLT SAPSYPTPSA
410 420 430 440 450
ALYTSTWSPP PSSLPPIFSA ASATTSVQTS ISGRTARTSH QPPLLHPGGK
460 470 480 490 500
SNAKIEKNGR KFPPLSASKK EELALLDQAA PMETNVTIKD LRVARETGVS
510 520 530 540 550
VTLMWNSSSS TQESSVTVLY SKYGEKDLLL VNADDYGKNQ ATINGLEPGS
560 570 580 590 600
QYVACVCPKG VGPREDLCIT FSTNRVEGRG SQWSLLLVVT STACVIVVPL
610 620 630 640 650
ICFLLYKVCK LQCTSDPFWE EDLSKETYIQ FETLSPRSQS IGELWTRRHR
660 670 680
DDGERLLLCS QSSVDSQMNL KSDGCRTEYY G
Length:681
Mass (Da):74,827
Last modified:May 14, 2014 - v1
Checksum:i02B8795BA4F3A176
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QNQ8J3QNQ8_MOUSE
Leucine-rich repeat, immunoglobulin...
Lrit3
560Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KF954709 mRNA Translation: AHI87499.1
AC111097 Genomic DNA No translation available.
CCDSiCCDS57256.2
RefSeqiNP_001274153.1, NM_001287224.1
UniGeneiMm.302549

Genome annotation databases

EnsembliENSMUST00000185462; ENSMUSP00000140184; ENSMUSG00000093865
GeneIDi242235
KEGGimmu:242235
UCSCiuc033hzp.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KF954709 mRNA Translation: AHI87499.1
AC111097 Genomic DNA No translation available.
CCDSiCCDS57256.2
RefSeqiNP_001274153.1, NM_001287224.1
UniGeneiMm.302549

3D structure databases

ProteinModelPortaliW8DXL4
SMRiW8DXL4
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSitePlusiW8DXL4

Proteomic databases

PRIDEiW8DXL4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000185462; ENSMUSP00000140184; ENSMUSG00000093865
GeneIDi242235
KEGGimmu:242235
UCSCiuc033hzp.1 mouse

Organism-specific databases

CTDi345193
MGIiMGI:2685267 Lrit3

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
KOG3510 Eukaryota
ENOG4110XFB LUCA
GeneTreeiENSGT00920000149011
OrthoDBiEOG091G0ACR

Miscellaneous databases

PROiPR:W8DXL4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000093865 Expressed in 8 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiW8DXL4 baseline and differential

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 2 hits
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 2 hits
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00369 LRR_TYP, 4 hits
SUPFAMiSSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiLRIT3_MOUSE
AccessioniPrimary (citable) accession number: W8DXL4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 7, 2016
Last sequence update: May 14, 2014
Last modified: November 7, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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