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Entry version 15 (11 Dec 2019)
Sequence version 1 (16 Apr 2014)
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Protein
Submitted name:

2-hydroxyglutaryl-CoA dehydratase

Gene

RF007C_15245

Organism
Ruminococcus flavefaciens 007c
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
2-hydroxyglutaryl-CoA dehydrataseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:RF007C_15245Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRuminococcus flavefaciens 007cImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1341157 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000019365 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
1341157.RF007C_15245

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 231BcrAD_BadFGInterPro annotationAdd BLAST225
Domaini321 – 575BcrAD_BadFGInterPro annotationAdd BLAST255
Domaini668 – 883DUF2229InterPro annotationAdd BLAST216

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002731 ATPase_BadF
IPR018709 CoA_activase_DUF2229
IPR008275 CoA_E_activase
IPR010327 FldB/FldC_alpha/beta

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01869 BcrAD_BadFG, 2 hits
PF09989 DUF2229, 1 hit
PF06050 HGD-D, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00241 CoA_E_activ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

W7UX31-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANKYSLGID VGSTTVKTVI TDADGNIVYS KYQRHLSKVK ETVTDQLKII
60 70 80 90 100
QADYPDETFT VCITGSAGLG LANSAGIPFV QEVHAAFLAV KKKQPDADAV
110 120 130 140 150
IELGGEDAKI IFLTGGVEQR MNGTCAGGTG AFIDQMATLL GITADQLDEL
160 170 180 190 200
SLHAQKIYPI ASRCGVFAKS DIQPLLNQGA RREDVAASIF QAVVDQTVSG
210 220 230 240 250
LAQGRTIEGK VLFLGGPLFF LSGLKKAFKK TLGLDDDNAM FPPEAPVFVA
260 270 280 290 300
YGCAIYAAAA GDSFHIEDII DKIRTAKASD DIVTGEPLFR SQAEYEGFID
310 320 330 340 350
RHRKFDLGYA DIHTYKGDAY LGIDAGSTTT KLVLITDDGR ILYHHYSSNQ
360 370 380 390 400
GQPLDKVSDQ VRRIYSEMNP GITIKGSAVT GYGEDLIKAG LSIDHGIVET
410 420 430 440 450
VAHFKAAAYF CPDVDFIIDI GGQDIKCFKI KNKSIDSIML NEACSSGCGS
460 470 480 490 500
FIQTFAMALG YDIAEFSQLG LFAEHPVDLG SRCTVFMNSS VKQAQKDGAT
510 520 530 540 550
VDDISAGLSS SIIKNAIYKV IRANSPDDLG KNIVVQGGTF LNDAVLRSFE
560 570 580 590 600
KELGRNVIRP AISGLMGAFG CALYAKERAG DEPSKIISAE ELENFTYTSR
610 620 630 640 650
SANCGGCTAH CQLNIINFGK GRRFISGNRC EKGGGMANKN TVPNLYEFKY
660 670 680 690 700
DSILNTVKTH QPRRYRGTVG LPLALGFYEQ LPFWHMLFTT LGFRTVISDE
710 720 730 740 750
SSRDMYYLGQ HTIPSDTVCY PAKLTHGHIE NLLDKGVDFI FYPCMSYNID
760 770 780 790 800
EGNSDNHFNC PVVAYYPELL IANNPRLNNE NFIHPYMDLN IRKNVIKVMG
810 820 830 840 850
QALKNYNVKG RIPEAVDKAY EALQTYRNSV TRKAMEIITQ ARAEGRKIIV
860 870 880 890 900
IAGRPYHIDK EINHGIHKLV SSLGMAVITE DSIAGLASTP KLGVLNQWTY
910 920 930 940 950
HSRLYRAAKY VTTQPDMQLI QLVSFGCGID AVTGDEVRHI LESRGKLYTQ
960 970 980
LKIDEINNLG AARIRLRSLV AAMEQADQKP AKKPVVQPV
Length:989
Mass (Da):108,234
Last modified:April 16, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDED19789022B9BC4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
ATAX01000028 Genomic DNA Translation: EWM52967.1

NCBI Reference Sequences

More...
RefSeqi
WP_037300136.1, NZ_ATAX01000028.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
EWM52967; EWM52967; RF007C_15245

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1341157.4.peg.2446

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ATAX01000028 Genomic DNA Translation: EWM52967.1
RefSeqiWP_037300136.1, NZ_ATAX01000028.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi1341157.RF007C_15245

Genome annotation databases

EnsemblBacteriaiEWM52967; EWM52967; RF007C_15245
PATRICifig|1341157.4.peg.2446

Family and domain databases

InterProiView protein in InterPro
IPR002731 ATPase_BadF
IPR018709 CoA_activase_DUF2229
IPR008275 CoA_E_activase
IPR010327 FldB/FldC_alpha/beta
PfamiView protein in Pfam
PF01869 BcrAD_BadFG, 2 hits
PF09989 DUF2229, 1 hit
PF06050 HGD-D, 1 hit
TIGRFAMsiTIGR00241 CoA_E_activ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiW7UX31_RUMFL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: W7UX31
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 16, 2014
Last sequence update: April 16, 2014
Last modified: December 11, 2019
This is version 15 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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