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Protein

dCTP deaminase

Gene

dcd

Organism
Sulfolobales archaeon AZ1
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the deamination of dCTP to dUTP.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

dCTP + H2O = dUTP + NH3.UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP (dUTP route).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. dCTP deaminase (dcd), dCTP deaminase (dcd)
  2. no protein annotated in this organism
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei115dCTPUniRule annotation1
Active sitei125Proton donor/acceptorUniRule annotation1
Binding sitei157dCTPUniRule annotation1
Binding sitei160dCTPUniRule annotation1
Binding sitei164dCTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi99 – 104dCTP bindingUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationImported
Biological processNucleotide metabolismUniRule annotation
LigandNucleotide-bindingUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00610; UER00665

Names & Taxonomyi

Protein namesi
Recommended name:
dCTP deaminaseUniRule annotation (EC:3.5.4.13UniRule annotation)
Alternative name(s):
Deoxycytidine triphosphate deaminaseUniRule annotation
Gene namesi
Name:dcdUniRule annotationImported
ORF Names:ASUL_09544Imported
OrganismiSulfolobales archaeon AZ1Imported
Taxonomic identifieri1326980 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesunclassified Sulfolobales
Proteomesi
  • UP000054284 Componenti: Unassembled WGS sequence

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini66 – 167dUTPaseInterPro annotationAdd BLAST102

Sequence similaritiesi

Belongs to the dCTP deaminase family.UniRule annotation

Phylogenomic databases

OrthoDBiPOG093Z0C6C

Family and domain databases

CDDicd07557 trimeric_dUTPase, 1 hit
Gene3Di2.70.40.10, 1 hit
HAMAPiMF_00146 dCTP_deaminase, 1 hit
InterProiView protein in InterPro
IPR011962 dCTP_deaminase
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
IPR033704 dUTPase_trimeric
PfamiView protein in Pfam
PF00692 dUTPase, 1 hit
SUPFAMiSSF51283 SSF51283, 1 hit
TIGRFAMsiTIGR02274 dCTP_deam, 1 hit

Sequencei

Sequence statusi: Complete.

W7KV07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLSDRDIKN YIHEKKLVIT PLSSDTVREN GVDLKVGDQI ARFLKLAEPV
60 70 80 90 100
DVDNPEEIKK AYVVTHGHEF IIGPHEHVLL TTLEYVKMPN DLVGFVNLRS
110 120 130 140 150
TFARLGLFIP PTIIDAGFEG QITIELVGSE FPVRLKKGTR FIHVIFAKTT
160 170
TPVENPYRGK YMGQTGVTLP KAP
Length:173
Mass (Da):19,380
Last modified:April 16, 2014 - v1
Checksum:i11EF0AEF35F6FC06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ASRH01000024 Genomic DNA Translation: EWG06442.1

Genome annotation databases

PATRICifig|1326980.6.peg.1903

Similar proteinsi

Entry informationi

Entry nameiW7KV07_9CREN
AccessioniPrimary (citable) accession number: W7KV07
Entry historyiIntegrated into UniProtKB/TrEMBL: April 16, 2014
Last sequence update: April 16, 2014
Last modified: June 20, 2018
This is version 24 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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