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Entry version 37 (16 Oct 2019)
Sequence version 1 (16 Apr 2014)
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Protein
Submitted name:

Phospholipid-transporting ATPase

Gene

CK202_1748

Organism
Plasmodium falciparum (isolate NF54)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Phospholipid-transporting ATPaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CK202_1748Imported, PFNF54_03780Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate NF54)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5843 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei20 – 37HelicalSequence analysisAdd BLAST18
Transmembranei71 – 100HelicalSequence analysisAdd BLAST30
Transmembranei106 – 128HelicalSequence analysisAdd BLAST23
Transmembranei601 – 619HelicalSequence analysisAdd BLAST19
Transmembranei644 – 663HelicalSequence analysisAdd BLAST20
Transmembranei670 – 690HelicalSequence analysisAdd BLAST21
Transmembranei1431 – 1448HelicalSequence analysisAdd BLAST18
Transmembranei1491 – 1515HelicalSequence analysisAdd BLAST25
Transmembranei1551 – 1570HelicalSequence analysisAdd BLAST20
Transmembranei1582 – 1602HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
W7K4C4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini57 – 110PhoLip_ATPase_NInterPro annotationAdd BLAST54
Domaini1385 – 1612PhoLip_ATPase_CInterPro annotationAdd BLAST228

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni244 – 318DisorderedSequence analysisAdd BLAST75
Regioni419 – 486DisorderedSequence analysisAdd BLAST68
Regioni837 – 859DisorderedSequence analysisAdd BLAST23
Regioni902 – 927DisorderedSequence analysisAdd BLAST26
Regioni1023 – 1060DisorderedSequence analysisAdd BLAST38

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili982 – 1011Sequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi273 – 295PolarSequence analysisAdd BLAST23
Compositional biasi297 – 311BasicSequence analysisAdd BLAST15
Compositional biasi423 – 467AcidicSequence analysisAdd BLAST45

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
FSIEQFC

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.1110.10, 2 hits
3.40.50.1000, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c

The PANTHER Classification System

More...
PANTHERi
PTHR24092 PTHR24092, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01494 ATPase_P-type, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

W7K4C4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVDDEELRKL RFLLSNKGGR IKYFFSYIFY KLFSHIYNKK NKKRERFVNI
60 70 80 90 100
HGRTFPNFFC DNKIKSTKYT ILTFIPLFLF YQFADFLNLF YLCVSLLQII
110 120 130 140 150
PIFNTGYVFT FVAPLLFIIF ISLINEVVDD LKRFIKDLEN NNEIYYSLLE
160 170 180 190 200
NGNFQKIYSK DIRVGDIILI KSKQRVPADC ILLRNLNKNE ESNFKVEEKR
210 220 230 240 250
LFNCFRWNKS NNVYNKINKS YYHFNKNIDN ELIDDRYNES NNNCSETSNN
260 270 280 290 300
LLFSENEKSQ KKGKKKQKKK LMLGDNNTNM NDFNFNPNDQ NNNMSNQLKK
310 320 330 340 350
KKKRKKKNNK SKKNININET TNETANYTYV KTDKIDGETD WKIKYPINIF
360 370 380 390 400
QNLKRLKDFF TIDILFILEQ PKNDIYKIEG SFVIFKYNPY GDFKTTENNN
410 420 430 440 450
HSLNDNQLLN YSFDMAKEDE GRVQDDEDVD EDDYDDDDDE DDDDDDEDDD
460 470 480 490 500
EDDDEEDDDE EDEEVNIPNN EKNDTQNLDD KKSVRRIFGT KNNTYSYGDD
510 520 530 540 550
DQVQNEKKKN LDRGYLNLEE KDTDYAYNKK DKKKEMVTFI DVEKGNNERT
560 570 580 590 600
INLNKKKNSV NTTGNRSSYV NDGKMCNVFN NEDNFNFYNV NYRKKLNYDN
610 620 630 640 650
FILFNSVITS SDVICLVIYT GSDTRVNMST QISKIKRGMI DEKLNLITLF
660 670 680 690 700
LFIILTLFSI YMCSVKLNNL WYLNFIRFML LFSSVIPISL SVNLNIAKIY
710 720 730 740 750
YTLLIQRDKE VESTIIKNSG IIENFGDIDY IFTDKTGTLT ENVMVLKVIH
760 770 780 790 800
IGFDVIHAEN EKNSIQGNNM ETKQKGNYNK KMLSYNLDDM NEDVDDTSIY
810 820 830 840 850
LASSNYSKHD RRNKNLRNGE LASFSYEMEN TSNINNNTKL RNYTKSNHHH
860 870 880 890 900
NNISDNELYD EKNYNDDQRS LSNYSDTSYG DVHLKNYKQN NMILNQNMGQ
910 920 930 940 950
NRNETLTKNN NNNNNNNNNN NNNNNNMSLE KKKKKVEKMV DEFLKYKSDP
960 970 980 990 1000
LDYYNDNIDD IEYLKRHRVF QTFLSFLICN NIRTLTKESS NKEKEKTKKK
1010 1020 1030 1040 1050
KERKEKDFQK NLYYILKVNR KKKDVQKNKK ENNSDNVKSS TQNKKKKHFS
1060 1070 1080 1090 1100
SNSSEDSETF SHSDVSYQCS SPDELAFLKY ATNCGFILKK KTASKIEIKY
1110 1120 1130 1140 1150
KNIMLEYDIL LHIPFSSETK RMSIFVRNVK NRNIYFFIKG ADNVLIKKCH
1160 1170 1180 1190 1200
EKYKTFIYEE SDHLSNIGLR VLVHGCLNVE EQFFHNFSAL YNKNKDVKGQ
1210 1220 1230 1240 1250
LENILEYVEK NIKVLAITGV EDKLQEGVGK TIEMLYNSGI KVWVLTGDKI
1260 1270 1280 1290 1300
ETAICICKNA NIKKKKHNIY IFRHENIKST SNLIREFNSI LHNIESYVLF
1310 1320 1330 1340 1350
FDNIIIQNCI KYIPNAFVDF AANARAVVCC RCSPIEKKEI AILIKTIKKK
1360 1370 1380 1390 1400
KILCIGDGGN DVAMIQSADI GIGVLGKEGK QVVHDSDIIV SKFKNIKKLI
1410 1420 1430 1440 1450
LYYGNNTFLQ TSSLCSFLIH RGFILTYLQF IYSYIFFSIP VSIFQGWLQI
1460 1470 1480 1490 1500
GYTTYYTTAP FLSLLLDIKI KKNLIYLYPE IYKNKKHKRK LDLKSFFIIV
1510 1520 1530 1540 1550
WISIFQGTVV MLGALKLFND NYNNLINISF SSLIVLEIMN IHLEVESWHP
1560 1570 1580 1590 1600
LMISANICSF IVYIFSMFIL RNYFDIMQIM SVMFWYKVIL IVIFAWLPFF
1610
IIKKVKNIIT PSQFFKLA
Length:1,618
Mass (Da):190,446
Last modified:April 16, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF69AC40DB02F639D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KE123842 Genomic DNA Translation: EWC87655.1
NYMT01000004 Genomic DNA Translation: PKC48335.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EWC87655; EWC87655; PFNF54_03780

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KE123842 Genomic DNA Translation: EWC87655.1
NYMT01000004 Genomic DNA Translation: PKC48335.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiW7K4C4

Genome annotation databases

EnsemblProtistsiEWC87655; EWC87655; PFNF54_03780

Phylogenomic databases

OMAiFSIEQFC

Family and domain databases

Gene3Di3.40.1110.10, 2 hits
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c
PANTHERiPTHR24092 PTHR24092, 1 hit
PfamiView protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiW7K4C4_PLAFO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: W7K4C4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 16, 2014
Last sequence update: April 16, 2014
Last modified: October 16, 2019
This is version 37 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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