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UniProtKB - W6UW42 (W6UW42_ECHGR)

Entry version 47 (12 Aug 2020)
Sequence version 1 (16 Apr 2014)
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Protein

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase

Gene

EGR_00105

Organism
Echinococcus granulosus (Hydatid tapeworm)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei341UniRule annotation1
Active sitei388UniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseUniRule annotationARBA annotation, TransducerUniRule annotationARBA annotation
Biological processLipid degradationUniRule annotation, Lipid metabolism

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesteraseUniRule annotation (EC:3.1.4.11UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:EGR_00105Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEchinococcus granulosus (Hydatid tapeworm)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6210 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Spiralia › Lophotrochozoa › Platyhelminthes › Cestoda › Eucestoda › Cyclophyllidea › Taeniidae › Echinococcus › Echinococcus granulosus group
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000019149 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini615 – 734PI-PLC Y-boxInterPro annotationAdd BLAST120
Domaini741 – 840C2InterPro annotationAdd BLAST100

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni497 – 521DisorderedSequence analysisAdd BLAST25
Regioni922 – 950DisorderedSequence analysisAdd BLAST29

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1048 – 1079Sequence analysisAdd BLAST32
Coiled coili1186 – 1209Sequence analysisAdd BLAST24
Coiled coili1258 – 1278Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Database of Orthologous Groups

More...OrthoDBi		368239at2759

Family and domain databases

Conserved Domains Database

More...CDDi		cd13361, PH_PLC_beta, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1230.10, 1 hit
2.60.40.150, 1 hit
3.20.20.190, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR011992, EF-hand-dom_pair
IPR001192, PI-PLC_fam
IPR016280, PLC-beta
IPR042531, PLC-beta_C_sf
IPR009535, PLC-beta_CS
IPR037862, PLC-beta_PH
IPR017946, PLC-like_Pdiesterase_TIM-brl
IPR015359, PLC_EF-hand-like
IPR000909, PLipase_C_PInositol-sp_X_dom
IPR001711, PLipase_C_Pinositol-sp_Y

The PANTHER Classification System

More...PANTHERi		PTHR10336, PTHR10336, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00168, C2, 1 hit
PF06631, DUF1154, 1 hit
PF09279, EF-hand_like, 1 hit
PF17787, PH_14, 1 hit
PF00388, PI-PLC-X, 1 hit
PF00387, PI-PLC-Y, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000956, PLC-beta, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00390, PHPHLIPASEC

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00239, C2, 1 hit
SM00148, PLCXc, 1 hit
SM00149, PLCYc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47473, SSF47473, 1 hit
SSF51695, SSF51695, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50004, C2, 1 hit
PS50008, PIPLC_Y_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

W6UW42-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSDIAKRQR TVPSTKAYDF VWRRPVPTAL REGSYFDRYE EETGALELGC 
        60         70         80         90        100
FLRVDEDGFF LFWKSETNEG QVLELSQVSD VRQGTKPKDE KLLGVLMERM 
       110        120        130        140        150
PSGGKNLDER IVTVCSGLDL VNISYTNFVA ASAEVASLWI QSVRGLTHNT 
       160        170        180        190        200
KAQNVCPMTQ LRKHWLRITL TVNPRGKIPV RVVTKTFASG RNERIIFQSL 
       210        220        230        240        250
KDLGLPSGKN DEVEPSDFTF ERFYELYHKI CPRTDIEELF KSLSHGRDTI 
       260        270        280        290        300
TADKMIEFLN EVQRDPRLNE ILYPYANRHT IRYIQETYDS RDKSNSSDTV 
       310        320        330        340        350
SLKGFYRYLM SDDNAPVFLD RLDIYQDMDQ PLCHYYINSS HNTYLIGRQF 
       360        370        380        390        400
GGKSSVEIYR QVLLAGCRCI ELDCWDGKGE DQEPIITHGK AMCSDILFKD 
       410        420        430        440        450
VIYAVRDTAF VTSEYPLIMS FENHCSKHQQ YKLAKYCEDI LGDMLLTKPL 
       460        470        480        490        500
DKHPLEPGVP LPSPEKLKRK ILIKNKRLDP DVEKHQLELF IKGQADPVQE 
       510        520        530        540        550
EDDVAEDPDP LGSTDCDVSP INGDIDPHPE TKIRPGSGQI NALSTSSAFS 
       560        570        580        590        600
SSLMGKLSET EMKRLIMKKV ALVILFLPLI ESQTLLKGTL TAEEEQAMLA 
       610        620        630        640        650
QYHYTGATKT IHPLLSSMVN YAQPVKFQGF DIAEDENIHY HMSSFSETVA 
       660        670        680        690        700
LGLMKNEAIE FVKYPFLLRG LRENACEACS PPQRLGLMLN IFWNAGCQMV 
       710        720        730        740        750
ALNFQTPDLA MQLNQGKFEY NGNCGYLLKP EFMRRPERQF DPFSESPMDG 
       760        770        780        790        800
VIAATCEVRI ISGQFLSDRK VGTYVEVDMY GLPTDTIRKE FRTRVVPNNG 
       810        820        830        840        850
LNPVYGEDAV FVFRKVVLPD LAVLRFAVYE DTGKLIGQRV LPLDGLQSGY 
       860        870        880        890        900
RHISLRTEGN FPLSLPTLFC RVSLTTYVPE GLNDLVDALS DPRAFLSKEE 
       910        920        930        940        950
QRMKQLASMG IDSSEIDEVS SSSTKLTSML KQRPVGSGPT LSSTTSGVPT 
       960        970        980        990       1000
GSAGCASAGG GGGGGSSSSG AGVGSASGLC LSCLGPSGDP HRLTPASVTG 
      1010       1020       1030       1040       1050
VAASTAYGSG TACIAVSTPG PSGNSTKKED KKEDPKFPSI SLAMLRSDKN 
      1060       1070       1080       1090       1100
YRRLVKKQAK ELESLQRRHE KEAAAMLRAH SLLTDKLNAS HAKAIASSTS 
      1110       1120       1130       1140       1150
SLRSTPQKVN GVGTPLKEAH IAQMNDLVRQ QTDEWSKLKC TQMSEIHTLV 
      1160       1170       1180       1190       1200
LTFIDSRKDL LLKSQFRDCK KFLNVTFLCH RRQDSSQILR DTHDEQKRLL 
      1210       1220       1230       1240       1250
KQIQERENKD MKAQQIKISL DSNRNVMNDP KLKNKAERDR RIRELKDYNT 
      1260       1270       1280       1290       1300
KRFIDQRKAQ AQRNDRQAQD LLRRHEEEEQ GVIAGVNRER DELIRNYREE 
      1310
LLASKRATMI
Length:1,310
Mass (Da):147,297
Last modified:April 16, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0AC55848202D5B41
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
APAU02000001 Genomic DNA Translation: EUB64836.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
APAU02000001 Genomic DNA Translation: EUB64836.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Phylogenomic databases

OrthoDBi368239at2759

Family and domain databases

CDDicd13361, PH_PLC_beta, 1 hit
Gene3Di1.20.1230.10, 1 hit
2.60.40.150, 1 hit
3.20.20.190, 2 hits
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR011992, EF-hand-dom_pair
IPR001192, PI-PLC_fam
IPR016280, PLC-beta
IPR042531, PLC-beta_C_sf
IPR009535, PLC-beta_CS
IPR037862, PLC-beta_PH
IPR017946, PLC-like_Pdiesterase_TIM-brl
IPR015359, PLC_EF-hand-like
IPR000909, PLipase_C_PInositol-sp_X_dom
IPR001711, PLipase_C_Pinositol-sp_Y
PANTHERiPTHR10336, PTHR10336, 1 hit
PfamiView protein in Pfam
PF00168, C2, 1 hit
PF06631, DUF1154, 1 hit
PF09279, EF-hand_like, 1 hit
PF17787, PH_14, 1 hit
PF00388, PI-PLC-X, 1 hit
PF00387, PI-PLC-Y, 1 hit
PIRSFiPIRSF000956, PLC-beta, 2 hits
PRINTSiPR00390, PHPHLIPASEC
SMARTiView protein in SMART
SM00239, C2, 1 hit
SM00148, PLCXc, 1 hit
SM00149, PLCYc, 1 hit
SUPFAMiSSF47473, SSF47473, 1 hit
SSF51695, SSF51695, 1 hit
PROSITEiView protein in PROSITE
PS50004, C2, 1 hit
PS50008, PIPLC_Y_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiW6UW42_ECHGR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: W6UW42
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 16, 2014
Last sequence update: April 16, 2014
Last modified: August 12, 2020
This is version 47 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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