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UniProtKB - W6UC10 (W6UC10_ECHGR)

Entry version 16 (12 Aug 2020)
Sequence version 1 (16 Apr 2014)
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Protein
Submitted name:

Integrator complex subunit 2

Gene

EGR_07011

Organism
Echinococcus granulosus (Hydatid tapeworm)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Integrator complex subunit 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:EGR_07011Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEchinococcus granulosus (Hydatid tapeworm)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6210 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Spiralia › Lophotrochozoa › Platyhelminthes › Cestoda › Eucestoda › Cyclophyllidea › Taeniidae › Echinococcus › Echinococcus granulosus group
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000019149 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

NucleusARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni999 – 1034DisorderedSequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1010 – 1034PolarSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Integrator subunit 2 family.ARBA annotation

Phylogenomic databases

Database of Orthologous Groups

More...OrthoDBi		173270at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026236, Int2_metazoa
IPR029321, INTS2

The PANTHER Classification System

More...PANTHERi		PTHR28608, PTHR28608, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF14750, INTS2, 3 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR02105, INTSUBUNIT2

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

W6UC10-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDLHAYRIDD EFSLVAIFPR VYFTVENLDS FIVEKFKEPS LLMTVVELLH 
        60         70         80         90        100
VLDSLAVVDI KKVWETSLLD TLKRVTTQVP LRSRVYTYND FEAHNSVESK 
       110        120        130        140        150
VKLVAQQLEH VLHEDADEQC ESYRCCSLLE SPTLLDTITA ITSAVLLGLH 
       160        170        180        190        200
NTDILPDVIA GLSIHCALNS RLLIERLVLN FPEKWYDIYE CLLGRISILK 
       210        220        230        240        250
GNSDHKGSAR CLAVLHHLST FVPDMNGLLN KCIQLRQLPS LVIQLAIKQS 
       260        270        280        290        300
NTGENFSLIN FFKRVLLDQG RKTQSWFGEY LKSAWETNPT LIADVNEKIL 
       310        320        330        340        350
SAISGILDDS KAVLPKEQLL PALEFLRTIA ALCGHTGFVL SSKLRSFVLH 
       360        370        380        390        400
LITHPTGRSE KAVNFICFCL AFIIGLRSCL FDNSVGLNEA SSGETEEQLV 
       410        420        430        440        450
VWLRRLISRQ DIFHTSLRQS SSYSEVLLLF GLLFNDSHPT TIRDIIVNTL 
       460        470        480        490        500
DIDAPCFVRN ISASRKLFAQ KVFTCQSIAA QAAHVPVTAC LNAHITGNLP 
       510        520        530        540        550
IHCVFQLLKN HAFNKNRVQI KGWIYRQICA SVRPLHPLML ELLEIYVTNA 
       560        570        580        590        600
LTQTVGLASS QMIGACGGCV PFTEAELFVQ FSDPAFGPDA RMCAPGATGF 
       610        620        630        640        650
VTDLAIDSVA DAVQMDLTPQ LLFLYYMLYI YDQELSSRST DNRGNQRSQA 
       660        670        680        690        700
KASLSQFSDK LWDAIPITYL LQYARSNLSS YRQLYPRLLQ LVTEHRPHLT 
       710        720        730        740        750
VGELTIQDEL LLDPLWKSAS SFQSFNSFCA AGHFATPTKA PLPNELLSGQ 
       760        770        780        790        800
LSIKVVIKIM LAVLVVQHQV RHSEGRLVAS KETLLCPTHF ADRILFFAVL 
       810        820        830        840        850
DQILTPGASL DSLKSAAAAC IRAVNALVET VNRQRGFSRL RHLLPYAEAI 
       860        870        880        890        900
GCRLPRILLE TAALSGNRRF TSAVCFLWRS LHCLMPRRLE VLTVKALSSK 
       910        920        930        940        950
KETYSRLTHH DLLKDPVENI VMAVDQRVYR CPPVLTLLIR IIDCNLRASR 
       960        970        980        990       1000
AFWWHRVISR HFIGLTSTIA SEKRETLTTA SATPLPLVPI TGDMEMQGFA 
      1010       1020       1030       1040       1050
RGRRTGGNGR STLEPASGSG IIGESSAASS SQPNALEPLA SDDLCDRLRT 
      1060       1070       1080       1090       1100
TLVTCQDATV VQLLLEFCLP TAEEKRLNSE VTDLREVQNI ICAFIHFLFI 
      1110       1120       1130       1140       1150
GDPNLAKVVF WQTYPRSLNP LATRAIPSIQ VCADTVLEVF VKSGSLEDVV 
      1160       1170       1180       1190       1200
FCLDFVSHLA LHCTFTSMLN LATYAVEVMH FIFTHLASLE EMASLLIACG 
      1210       1220       1230       1240       1250
PAFCRLGSAF PSIGHRLAAI LLSAMAALAE AVTLAGGSRH RDILVRRIVT 
      1260       1270       1280       1290       1300
LKSVVLSDLN DASPKSLDLV KGDADSLPRL HHLTRTEKCF FACVQAMFWF 
      1310       1320       1330       1340 
NQLVRLTTAQ RRLSLPPSIE ELPSLLTCQS FSSLYSSYHS EK
Length:1,342
Mass (Da):149,422
Last modified:April 16, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDD5D46E5D04BE363
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
APAU02000068 Genomic DNA Translation: EUB58091.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
APAU02000068 Genomic DNA Translation: EUB58091.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Phylogenomic databases

OrthoDBi173270at2759

Family and domain databases

InterProiView protein in InterPro
IPR026236, Int2_metazoa
IPR029321, INTS2
PANTHERiPTHR28608, PTHR28608, 1 hit
PfamiView protein in Pfam
PF14750, INTS2, 3 hits
PRINTSiPR02105, INTSUBUNIT2

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiW6UC10_ECHGR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: W6UC10
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 16, 2014
Last sequence update: April 16, 2014
Last modified: August 12, 2020
This is version 16 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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