Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Multidrug resistance protein 1

Gene

ABCB1

Organism
Felis silvestris (Wild cat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi410 – 417ATPPROSITE-ProRule annotation8
Nucleotide bindingi1053 – 1060ATPPROSITE-ProRule annotation8

GO - Molecular functioni

Keywordsi

LigandATP-bindingPROSITE-ProRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Multidrug resistance protein 1Imported
Gene namesi
Name:ABCB1Imported
OrganismiFelis silvestris (Wild cat)Imported
Taxonomic identifieri9683 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei31 – 54HelicalSequence analysisAdd BLAST24
Transmembranei98 – 122HelicalSequence analysisAdd BLAST25
Transmembranei173 – 191HelicalSequence analysisAdd BLAST19
Transmembranei197 – 216HelicalSequence analysisAdd BLAST20
Transmembranei276 – 299HelicalSequence analysisAdd BLAST24
Transmembranei691 – 717HelicalSequence analysisAdd BLAST27
Transmembranei737 – 760HelicalSequence analysisAdd BLAST24
Transmembranei842 – 862HelicalSequence analysisAdd BLAST21
Transmembranei918 – 937HelicalSequence analysisAdd BLAST20
Transmembranei957 – 978HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 340ABC transmembrane type-1InterPro annotationAdd BLAST307
Domaini375 – 611ABC transporterInterPro annotationAdd BLAST237
Domaini695 – 983ABC transmembrane type-1InterPro annotationAdd BLAST289
Domaini1018 – 1256ABC transporterInterPro annotationAdd BLAST239

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili250 – 270Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR030258 MDR1
IPR027417 P-loop_NTPase
PANTHERiPTHR24221:SF251 PTHR24221:SF251, 1 hit
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

Sequencei

Sequence statusi: Complete.

W6RRL6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGEKSKKEKK EKKPTVSTLA MFRYSNWLDR FYMLVGTVAA IIHGAALPLM
60 70 80 90 100
MLVFGDMTDS FANAGISRNL TTLNITGESI VNDSYFINRL EEEMTTYAYY
110 120 130 140 150
YSGIGAGVLV AAYIQVSFWC LAAGRQILKI RKQFFHAIMR QEVGWFDVHD
160 170 180 190 200
VGELNTRLTD DVSKINEGIG DKIGMFFQSL ATFFIGFIVG FTRGWKLTLV
210 220 230 240 250
ILAISPVLGL SAAIWAKILS SFTDKELLAY AKAGAVAEEV LAAIRTVIAF
260 270 280 290 300
GGQKKELERY NKNLEEAKRI GIKKAITANI SIGIAFLLIY ASYALAFWYG
310 320 330 340 350
TSLVLSHEYS IGQVLTVFFS VLIGAFSVGQ ASPSIEAFAN ARGAAYEIFK
360 370 380 390 400
IIDNKPSIDS YSKNGHKPDN IKGNLEFKNV HFSYPSRKEV KILKGLNLKV
410 420 430 440 450
QSGQTVALVG NSGCGKSTTV QLMQRLYDPT DGMVSIDGQD IRTINVRYLR
460 470 480 490 500
EIIGVVSQEP VLFATTIAEN ICYGRENVTM EEIEKAVKEA NAYDFIMKLP
510 520 530 540 550
NKFDTLVGER GAQLSGGQKQ RIAIARALVR NPKILLLDEA TSALDSESEA
560 570 580 590 600
VVQVALDKAR KGRTTIVVAH RLSTIRNADV IAGFDDGVIV EKGNHDELMK
610 620 630 640 650
EEGIYFKLVT MQTRGNEIEL ENAVYESISE IDALEMSPKD SGSSLIRRRS
660 670 680 690 700
TRKSIHASQG QDRKLGTKEN LDEHVPPVSF WRILKLNITE WPYFVVGIFC
710 720 730 740 750
AIINGGLQPA FSVIFSRIIG VFTRVEDPET KRQNSNIFSL LFLVLGIISF
760 770 780 790 800
ITFFLQGFTF GKAGEILTKR LRYMVFRSML RQDVSWFDDP KNTTGALTTR
810 820 830 840 850
LANDAAQVKG AIGSRLAIIT QNIANLGTGI IISLIYGWQL TLLLLAIVPI
860 870 880 890 900
IAIAGVVEMK MLSGQALKDK KELEGAGKIA TEAIENFRTV VSLTREQKFE
910 920 930 940 950
YMYAQSLQVP YRNSLRKAHI FGISFSITQA MMYFSYAGCF RFGAYLVAHE
960 970 980 990 1000
FMDFQDVLLV FSAIVFGAMA VGQVSSFAPD YAKAKVSAAH VIMIIEKIPL
1010 1020 1030 1040 1050
IDSYSTEGLM PNTLEGNVTF NEVMFNYPTR PDIPVLQGLS LEVKKGQTLA
1060 1070 1080 1090 1100
LVGSSGCGKS TVVQLLERFY DPMAGTVLID GKEIKHLNVQ WLRAHMGIVS
1110 1120 1130 1140 1150
QEPILFDCSI GENIAYGDNS RVVSQEEIVR AAKEANIHPF IETLPDKYNT
1160 1170 1180 1190 1200
RVGDKGTQLS GGQKQRIAIA RALVRQPRIL LLDEATSALD TESEKVVQEA
1210 1220 1230 1240 1250
LDKAREGRTC IVIAHRLSTI QNADLIVVFQ NGKVKEHGTH QQLLAQKGIY
1260
FSMVSVQAGA KR
Length:1,262
Mass (Da):139,682
Last modified:April 16, 2014 - v1
Checksum:i66CCB17B4A56C9C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HG917104 mRNA Translation: CDM63425.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HG917104 mRNA Translation: CDM63425.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR030258 MDR1
IPR027417 P-loop_NTPase
PANTHERiPTHR24221:SF251 PTHR24221:SF251, 1 hit
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiW6RRL6_FELSI
AccessioniPrimary (citable) accession number: W6RRL6
Entry historyiIntegrated into UniProtKB/TrEMBL: April 16, 2014
Last sequence update: April 16, 2014
Last modified: July 18, 2018
This is version 26 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again