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Protein
Submitted name:

Frizzled-8

Gene

fzd8

Organism
Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental proteinSAAS annotation, ReceptorSAAS annotation
Biological processWnt signaling pathwaySAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Frizzled-8Imported
Gene namesi
Name:fzd8Imported
OrganismiIctalurus punctatus (Channel catfish) (Silurus punctatus)Imported
Taxonomic identifieri7998 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiSiluriformesIctaluridaeIctalurus
Proteomesi
  • UP000221080 Componenti: Genome assembly

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei239 – 262HelicalSequence analysisAdd BLAST24
Transmembranei274 – 294HelicalSequence analysisAdd BLAST21
Transmembranei314 – 343HelicalSequence analysisAdd BLAST30
Transmembranei364 – 383HelicalSequence analysisAdd BLAST20
Transmembranei413 – 434HelicalSequence analysisAdd BLAST22
Transmembranei455 – 476HelicalSequence analysisAdd BLAST22
Transmembranei504 – 526HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_501354005026 – 584Sequence analysisAdd BLAST559

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 91PROSITE-ProRule annotation
Disulfide bondi38 ↔ 84PROSITE-ProRule annotation
Disulfide bondi75 ↔ 113PROSITE-ProRule annotation
Disulfide bondi102 ↔ 143PROSITE-ProRule annotation
Disulfide bondi106 ↔ 130PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 146FZInterPro annotationAdd BLAST122
Domaini238 – 533G_PROTEIN_RECEP_F2_4InterPro annotationAdd BLAST296

Sequence similaritiesi

Belongs to the G-protein coupled receptor Fz/Smo family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

KOiK02375

Family and domain databases

Gene3Di1.10.2000.10, 1 hit
InterProiView protein in InterPro
IPR015526 Frizzled/SFRP
IPR000539 Frizzled/Smoothened_TM
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR017981 GPCR_2-like
PANTHERiPTHR11309 PTHR11309, 1 hit
PfamiView protein in Pfam
PF01534 Frizzled, 1 hit
PF01392 Fz, 1 hit
PRINTSiPR00489 FRIZZLED
SMARTiView protein in SMART
SM00063 FRI, 1 hit
SM01330 Frizzled, 1 hit
SUPFAMiSSF63501 SSF63501, 1 hit
PROSITEiView protein in PROSITE
PS50038 FZ, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequencei

Sequence statusi: Complete.

W5U7U1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERYLSGIYL LLALLTLRRS SGATAKELSC QEIAVPLCKG IGYNYTYMPN
60 70 80 90 100
QFNHDTQDEA GLEVHQFWPL VEIQCSADLR FFLCSMYTPI CLEDYKKPLP
110 120 130 140 150
PCRSVCERAR AGCAPLMRQY GFPWPDRMRC ELLPVQGNPD TLCMDYNRTD
160 170 180 190 200
ATTAAPVLPK PTSYPGRAHG SGRVASGGHP KRKPAPQPCE AGCQCRAPMV
210 220 230 240 250
RVSSERHPLY NRVKTGRTPN CAMPCHNPFF TPDERAFTAF WIGLWSVLCF
260 270 280 290 300
VSTFATVATF LIDMERFKYP ERPIIFLSAC YMFVSVGYIV RLIAGHERVA
310 320 330 340 350
CSREHDVEHV HYETTGPALC TVVFLLIYFF GMASSIWWVI LSLTWFLAAG
360 370 380 390 400
MKWGNEAIAS YSQYFHLAAW LIPSMKSIAV LALSSVDGDP VAGICYVGNQ
410 420 430 440 450
NLDNLRGFVL APLLIYLCIG AMFLLAGFVS LFRIRSVIKQ GGTKTDKLEK
460 470 480 490 500
LMIRIGVFTV LYTVPAAVIV ACYFYEQHNR QRWEAAHNCA CALDRERDAE
510 520 530 540 550
RPDYAVFMLK YFMCLAVGIT SGVWVWSGKT VESWRALCAR CFRCRWAGKG
560 570 580
ASSSAYSDVS AGLTWRSGTA SSVSCAKQMP LSRV
Length:584
Mass (Da):65,411
Last modified:April 16, 2014 - v1
Checksum:i6087DDE8DFF5CADC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JT407661 mRNA Translation: AHH38066.1
RefSeqiXP_017336113.1, XM_017480624.1
UniGeneiIpu.73511

Genome annotation databases

GeneIDi108272300
KEGGiipu:108272300

Similar proteinsi

Entry informationi

Entry nameiW5U7U1_ICTPU
AccessioniPrimary (citable) accession number: W5U7U1
Entry historyiIntegrated into UniProtKB/TrEMBL: April 16, 2014
Last sequence update: April 16, 2014
Last modified: February 28, 2018
This is version 23 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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